Vascular Sealing Device

血管封闭装置

• 批准号: 6836827
• 负责人: Kevin Marchitto
• 金额: $ 12.54万
• 依托单位: ROCKY MOUNTAIN BIOSYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6836827
• 关键词: biomaterial development /preparation; biomedical equipment development; heart catheterization; surgery material /equipment; surgical wound

DESCRIPTION (provided by applicant): Over 7 million catheterization procedures are performed worldwide each year, with a 10-20% complication rate in closing the vascular access site. The routine administration of anticoagulant medication can further delay sealing the vessel. Manual compression has been the standard of care for closure after percutaneous coronary interventions, but it requires 4-12 hours of bed rest, significant medical staff time, and associated higher costs. Recently, several closure devices have been introduced, but complication rates are still high and immediate ambulation is still not recommended. Rocky Mountain Biosystems, Inc., proposes developing a new technology (VeniSeal) to address the vascular closure problem. VeniSeal which uses a proprietary sealing compound that is activated using inductive coupling to achieve immediate and secure closure of both the sheath tract and vessel puncture. The sealing process can be done in the presence of blood and excess hemostatic pressure. In Phase I, we will build a prototype VeniSeal activation device, coil, and improve the adhesive compound. The device and adhesive will be used to seal vascular openings in ex vivo laboratory tests to evaluate the potential of this method to seal wounds in humans. In Phase II, a simple applicator will be designed and tested in animals.

描述（由申请人提供）： 每年在全球范围内执行超过700万个导管插入程序，关闭血管通道的并发症率为10-20％。抗凝药物的常规给药可以进一步延迟密封该血管。经皮冠状动脉干预措施后，手动压缩一直是关闭的护理标准，但需要4-12个小时的床休息，大量的医务人员时间和更高的成本。最近，已经引入了一些封闭设备，但并发症率仍然很高，不建议立即进行移动。 Rocky Mountain Biosystems，Inc。提议开发一种新技术（Veniseal）来解决血管封闭问题。威尼斯使用专有密封化合物，该化合物使用电感耦合激活，以立即封闭护套道和容器穿刺。密封过程可以在存在血液和止血压力的情况下完成。 在第一阶段，我们将构建一个原型的威尼斯激活装置，线圈并改善粘合剂化合物。该设备和粘合剂将用于在离体实验室测试中密封血管开口，以评估这种方法密封人体伤口的潜力。在第二阶段，将在动物中设计和测试一个简单的涂抹器。

项目成果

Progress towards seamless tissue fusion for wound closure.

用于伤口闭合的无缝组织融合的进展。

• DOI: 10.1016/j.otc.2004.10.029
• 发表时间: 2005
• 期刊: Otolaryngologic clinics of North America.
• 作者: Flock,StephenT;Marchitto,KevinS
• 通讯作者: Marchitto,KevinS