2006 Biophysical Discussions - Molecuar Motors: Point Counterpoint

2006 生物物理讨论 - 分子马达：点对位

• 批准号: 7174436
• 负责人: STEVEN S ROSENFELD
• 金额: $ 0.5万
• 依托单位: BIOPHYSICAL SOCIETY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-18 至 2007-09-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7174436
• 关键词: cytoskeletal proteins; enzyme activity; meeting /conference /symposium; protein structure function; protein transport; travel

DESCRIPTION (provided by applicant): The 2006 Biophysical Society Discussions, entitled "Molecular Motors-Point Counterpoint", is devoted to a critical evaluation of the current state of our knowledge about these diverse and pathophysiologically-relevant enzymatic machines-a discussion that will help resolve outstanding questions regarding motor function and lead to the development of new ideas about future directions. It will be held in Asilomar, California, from October 19-22, 2006. Although this field has made rapid progress in recent years, major unresolved questions remain. Do all motors have common structural elements that are shared by distinct motor superfamilies? If so, what does this tell us about what it takes to construct a motor? How do different motors convert the energy of ATP hydrolysis into force and movement, and are similar mechanisms used by all of these? How do motors determine their direction of movement, and how are they regulated? What can structural and enzymatic studies in vitro tell us about how a motor functions in the cell, and vice versa. A diverse group of speakers and participants with a broad range of expertise from molecular structure to single molecule mechanics to molecular genetics and cell biology will interact in a forum designed to critically evaluate our state of knowledge and develop new ideas regarding the future direction of research efforts in this field. Addressing these unresolved issues has become a particularly pressing concern as we have come to appreciate the central role that molecular motors play in the pathophysiology of a wide range of diseases-from cancer to atherosclerosis to amyotrophic lateral sclerosis to Alzheimer's disease.

描述（由申请人提供）：2006 年生物物理学会讨论题为“分子马达-点对点”，致力于对我们对这些多样化且与病理生理学相关的酶机器的了解现状进行批判性评估，该讨论将有助于解决有关运动功能的突出问题，并引发有关未来方向的新想法的发展。会议将于 2006 年 10 月 19 日至 22 日在加利福尼亚州阿西洛玛举行。尽管该领域近年来取得了快速进展，但仍存在重大未解决问题。所有电机是否都具有由不同电机家族共享的共同结构元件？如果是这样，这告诉我们什么是制造电机需要什么？不同的马达如何将 ATP 水解的能量转化为力和运动，所有这些马达都使用类似的机制吗？电机如何确定其运动方向以及如何对其进行调节？体外结构和酶学研究可以告诉我们运动如何在细胞中发挥作用，反之亦然。拥有从分子结构到单分子力学到分子遗传学和细胞生物学等广泛专业知识的多元化演讲者和参与者将在一个论坛上进行互动，该论坛旨在批判性地评估我们的知识状况并就未来的研究工作方向提出新的想法在这个领域。解决这些未解决的问题已成为一个特别紧迫的问题，因为我们已经认识到分子马达在从癌症到动脉粥样硬化到肌萎缩侧索硬化症到阿尔茨海默氏病等多种疾病的病理生理学中发挥的核心作用。