Gordon Res. Conf: Signal Transduction Within The Nucleus

戈登水库。

• 批准号: 6939703
• 负责人: Daniel M. Raben
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6939703
• 关键词: biological signal transduction; cell nucleus; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): This application seeks partial funding for a new Gordon Research conference on Signal Transduction within the Nucleus to be held February 6-11, 2005 at the Rancho Santa Barbara Marriott, Buellton, California. The funds requested will be used exclusively to support the conference and travel expenses of junior investigators who will be attending the conference and presenting their work as invited presentations, short talks or posters. The broad goal of this conference is to provide a form for review and discussion of recent research on the emerging field of nuclear signaling. This field centers on the novel concept that, similar to the agonist-induced metabolism at the plasma membrane, agonist stimulation leads to the generation of second messengers at and within the nucleus that leads to the production of nuclear localized second messengers. The mechanisms involved in regulating the generation and metabolism of these second messengers, and their precise physiological roles, are part of a complex picture that involves many enzymes and regulatory molecules. This conference brings together a wide variety of investigators focused on understanding the agonist-induced modulation of these components. Some of the principal enzymes include phosphoinositide-specific phospholipase Cs, phosphatidylinositol 3-kinases, phosphatidylcholine-specific phospholipase Cs, phospholipase A2s, lipoxygenases, cyclooxygenases, sphingomyelinases and glycosylating enzymes. These enzymes modulate the levels of key signaling molecules such as diacylglycerol, inositol phosphates, D-3 phosphonylated phosphoinositides, arachidonic acid and related eicosanoid, glycoproteins, glycolipids and sphingolipids. To address important physiological roles, other topics will include nuclear events that are regulated by the nuclear signaling pathways such as chromatin remodeling, transcription and RNA transport. Additional topics focus on how these pathways contribute to disease processes. The requested funds will be invaluable to the support of this conference.

说明（由申请人提供）：本申请为将于 2005 年 2 月 6 日至 11 日在加利福尼亚州布尔顿的兰乔圣巴巴拉万豪酒店举行的关于细胞核内信号转导的戈登研究新会议寻求部分资助。所申请的资金将专门用于支持参加会议并以受邀演讲、简短演讲或海报形式展示其工作的初级研究人员的会议费用和差旅费。本次会议的总体目标是提供一种形式来回顾和讨论新兴核信号领域的最新研究。该领域的中心是一个新概念，即与激动剂诱导的质膜代谢类似，激动剂刺激导致细胞核内和细胞核内第二信使的产生，从而导致核局部第二信使的产生。调节这些第二信使的产生和代谢的机制及其精确的生理作用是涉及许多酶和调节分子的复杂图景的一部分。这次会议汇集了各种各样的研究人员，他们致力于了解这些成分的激动剂诱导的调节。一些主要酶包括磷酸肌醇特异性磷脂酶Cs、磷脂酰肌醇3-激酶、磷脂酰胆碱特异性磷脂酶Cs、磷脂酶A2、脂氧合酶、环加氧酶、鞘磷脂酶和糖基化酶。这些酶调节关键信号分子的水平，例如二酰基甘油、磷酸肌醇、D-3 膦酰化磷酸肌醇、花生四烯酸和相关的类二十烷酸、糖蛋白、糖脂和鞘脂。为了解决重要的生理作用，其他主题将包括受核信号通路调节的核事件，例如染色质重塑、转录和 RNA 运输。其他主题重点关注这些途径如何促进疾病过程。所请求的资金对于支持本次会议将是无价的。