FASEB RESEARCH CONFERENCE: NUCLEAR STRUCTURE AND CANCER

FASEB 研究会议：核结构与癌症

• 批准号: 6737287
• 负责人: Ronald Berezney
• 金额: $ 0.5万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-16 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6737287
• 关键词: DNA replication; cell component structure /function; cell nucleus; gene expression; genetic regulation; meeting /conference /symposium; neoplastic cell; neoplastic process

DESCRIPTION (provided by applicant): This application is for partial funding for the 2003 FASEB Summer Research Conference on "Nuclear Structure and Cancer" to be held June 7-12, 2003 at the Vermont Academy in Saxtons River, Vermont. The conference is under the auspices of the Federation of American Societies for Experimental Biology (FASEB). There will be nine regular platform sessions, two workshops and two poster sessions. Young investigators will be encouraged to give short talks at the regular platform and workshop sessions by selection from the submitted abstracts. There will also be a special "late breaking development" session in which participants will be selected to give short talks. This conference will provide a forum to evaluate the fundamental regulatory and clinical implications of modified organization of nucleic acids and regulatory proteins that control gene replication and expression in nuclei of tumors cells. The study of tumor-related changes in nuclear morphology and the subnuclear organization of regulatory factors is gaining increased attention. With this in mind there is a need for a conference that is dedicated to examining the structural and functional properties of the interphase cell nucleus in cells that are compromised with the onset and progression of cancer. This is the only major meeting in the world that focuses on this specific topic. Correlations between nuclear morphology and gene replication and expression will be systematically explored. There will be a concerted effort to critically evaluate findings that interface between nuclear organization, genomic function and regulation. Consideration will be given to contributions from cellular, biochemical, genetic and molecular approaches and their integration into multidisciplinary approaches for understanding the connections among genomic organization, function and cancer. In so doing this meeting will address experimental strategies and high resolution state-of-the-art methodologies for defining in cancer cells alterations in nuclear architecture related to changes in gene replication, expression and regulation.

说明（由申请人提供）：本申请为 2003 年 FASEB 夏季研究会议“核结构与癌症”提供部分资助，该会议将于 2003 年 6 月 7 日至 12 日在佛蒙特州萨克斯顿河的佛蒙特学院举行。 该会议由美国实验生物学会联合会（FASEB）主办。 将有九场定期平台会议、两场研讨会和两场海报会议。 将鼓励年轻研究人员通过从提交的摘要中进行选择，在定期平台和研讨会上进行简短的演讲。 还将有一个特别的“最新进展”会议，其中将选择参与者进行简短的演讲。 本次会议将提供一个论坛来评估控制肿瘤细胞核中基因复制和表达的核酸和调节蛋白的修饰组织的基本调节和临床意义。 与肿瘤相关的核形态变化和调节因子的亚核组织的研究越来越受到关注。 考虑到这一点，需要召开一次会议，专门研究与癌症发生和进展相关的细胞中间期细胞核的结构和功能特性。 这是世界上唯一专注于这一特定主题的重大会议。 将系统地探索核形态与基因复制和表达之间的相关性。 我们将齐心协力，批判性地评估核组织、基因组功能和调控之间的相互作用的发现。 将考虑细胞、生化、遗传和分子方法的贡献，并将它们整合到多学科方法中，以了解基因组组织、功能和癌症之间的联系。 为此，本次会议将讨论实验策略和高分辨率最先进的方法，用于定义癌细胞中与基因复制、表达和调节变化相关的核结构变化。