CONFERENCE ON THE NUCLEAR MATRIX

核基质会议

• 批准号: 2728442
• 负责人: Ronald Berezney
• 金额: $ 0.38万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-13 至 1999-03-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2728442
• 关键词: cellular oncology; meeting /conference /symposium; nuclear matrix; travel

DESCRIPTION: There is a growing awareness of interrelationship between nuclear architecture and the regulation of gene expression. Particularly significant is evidence supporting contributions of the nuclear matrix to these processes. The nuclear matrix is involved in gene localization and in the control of replication and transcription. It is also a site for the targeting and integration of signaling mechanisms mediated by physiological regulators of gene expression including steroid hormones and activators of second messenger regulatory pathways. Equally important, nuclear matrix proteins reflect unique cell and tissue types and undergo modifications during differentiation. Specific nuclear matrix proteins are associated with breast, prostate, colon, bladder and bone cancer with characteristic changes during tumor progression. Nuclear matrix proteins, therefore, provide a basis for diagnosis and prognosis of cancer and potentially other diseases. This meeting will focus on the rapidly growing areas of nuclear matrix research and will cover a wide span of topics as summarized above. Coverage of this research in meetings is poorly represented in relationship to the broad range interest in this topic. It is a unique opportunity for researchers in this field who span a wide range of area to bond together and exchange the latest information and concepts. The first keystone Symposium on the Nuclear Matrix was held in April, 1995 and received rave reviews from many who attended it. Many prominent participants rated it one of the most exciting meetings that they have ever attended. With the developments in this field over the past two years we have every reason to believe that the April, 1998 meeting will be just as exciting and likely even more rewarding than the previous one.

描述：人们越来越认识到不同领域之间的相互关系。 核结构和基因表达的调控。 特别重要的是支持的贡献的证据 这些过程的核基质。 核基质参与 基因定位以及复制和转录的控制。 它也是信号定位和整合的站点 基因表达生理调节因子介导的机制 包括类固醇激素和第二信使调节激活剂 途径。 同样重要的是，核基质蛋白反映了独特的 细胞和组织类型并在分化过程中发生改变。 特定的核基质蛋白与乳腺、前列腺、 结肠癌、膀胱癌和骨癌在肿瘤过程中具有特征性变化 进展。 因此，核基质蛋白提供了基础 癌症和其他潜在疾病的诊断和预后。 这 会议将重点关注核矩阵快速增长的领域 研究并将涵盖上述概述的广泛主题。 会议中对这项研究的报道很少 与对该主题的广泛兴趣的关系。 它是一个独特的 为该领域跨广泛领域的研究人员提供机会 联系在一起并交流最新的信息和概念。 这 1995年4月举行第一届核矩阵基石研讨会 并获得了众多与会者的好评。 许多杰出的 与会者将其评为最激动人心的会议之一 曾经参加过。 随着近两年该领域的发展 多年来我们有充分的理由相信 1998 年 4 月的会议将 与之前一样令人兴奋，甚至可能更有价值 一。