Improvement of University of Oregon Animal Research Facilities

俄勒冈大学动物研究设施的改进

• 批准号: 7875914
• 负责人: KIMBERLY Andrews ESPY
• 金额: $ 911.7万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-31 至 2015-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7875914
• 关键词: Aquaculture; Complement; Cryopreservation; Development; Equipment; Faculty; Fishes; Funding; Gasterosteidae; Genes; Genetic; Genomics; Goals; Housing; International; Laboratory Animal Production and Facilities; Mammals; Modeling; Mus; Mutate; Oregon; Productivity; Research; Research Personnel; Resources; Safety; Savings; Stress; Translating; Universities; Work; Zebrafish; animal care; animal facility; animal welfare research; design; genetic evolution; genome-wide; human disease; improved; innovation; pressure; programs; repository; sperm cell; success

DESCRIPTION (provided by applicant): Our goal is to expand and renovate core animal facilities at the University of Oregon (UO) to increase productivity and impact of PHS funded research, promote safety and welfare of research animals, researchers, and animal care staff, and expand a cryopreservation repository for genome-wide research. The UO is a pioneer in using fish models for research in vertebrate development, genetics, genomics, evolution, and genetic contributions to human disease. Because of this expertise, UO houses the Zebrafish International Resource Center (ZIRC). UO has begun to translate discoveries made in these models into mammals, with an ambitious program in mouse genetics, involving new hires and current junior and senior faculty. The success of UO research programs has put serious pressure on the Zebrafish, Stickleback, and Mouse Facilities, and on ZIRC. We propose to alleviate this pressure by a synergistic program of construction, renovation, and equipment purchase, including innovative sustainable design strategies to increase energy savings. (1) We propose new construction, renovation, and purchase of new aquaculture equipment in our Zebrafish Facility. This will increase the number of lines we can maintain and improve work flow efficiency. (2) We propose renovation of existing space and purchase of new equipment to establish a new Stickleback Facility. The new facility will complement our very small existing facility that houses the only inbred lines worldwide, increase the number of lines we can maintain, and improve work flow. (3) We propose to purchase equipment for a new Mouse Facility in a building UO is constructing. This will increase the number of lines we can maintain, alleviate stress on the mice, and enable several senior faculty to expand their research programs to include mice. (4) We propose to purchase new cryopreservation equipment for ZIRC. This equipment will be housed in a building UO is constructing adjacent to ZIRC. Recent technological breakthroughs are enabling researchers to mutate and functionally annotate every zebrafish gene. The new equipment will allow ZIRC to cryopreserve sperm from the extensive genetic and genomic resources created by this effort.

描述（由申请人提供）：我们的目标是扩建和翻新俄勒冈大学 (UO) 的核心动物设施，以提高 PHS 资助的研究的生产力和影响力，促进研究动物、研究人员和动物护理人员的安全和福利，并扩大用于全基因组研究的冷冻保存库。俄勒冈大学是利用鱼类模型研究脊椎动物发育、遗传学、基因组学、进化以及人类疾病的遗传贡献的先驱。凭借这一专业知识，俄勒冈大学设有斑马鱼国际资源中心 (ZIRC)。俄勒冈大学已开始将这些模型的发现转化为哺乳动物，并在小鼠遗传学方面开展了一项雄心勃勃的计划，涉及新员工以及现任初级和高级教师。俄勒冈大学研究项目的成功给斑马鱼、刺鱼和小鼠设施以及 ZIRC 带来了巨大的压力。我们建议通过建设、改造和设备采购的协同计划来缓解这一压力，包括创新的可持续设计策略以增加节能。 (1) 我们建议在我们的斑马鱼设施中新建、改造和购买新的水产养殖设备。这将增加我们可以维护的线路数量并提高工作流程效率。 (2) 我们建议改造现有空间并购买新设备以建立新的刺鱼设施。新设施将补充我们现有的小型设施（该设施拥有全球唯一的自交系），增加我们可以维护的品系数量，并改善工作流程。 (3) 我们建议为 UO 正在建造的大楼内的新鼠标设施购买设备。这将增加我们可以维持的细胞系数量，减轻小鼠的压力，并使一些高级教师能够扩大他们的研究项目以包括小鼠。 (4)我们建议为ZIRC购买新的冷冻保存设备。该设备将安装在 UO 正在 ZIRC 附近建造的大楼内。最近的技术突破使研究人员能够对每个斑马鱼基因进行突变和功能注释。新设备将使 ZIRC 能够冷冻保存由此产生的广泛遗传和基因组资源中的精子。