Training Program in Developmental and Stem Cell Biology

发育和干细胞生物学培训计划

• 批准号: 10614535
• 负责人: Debra Silver
• 金额: $ 40.42万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614535
• 关键词: Development; Training Programs; stem cell biology

Project Summary The Duke Development and Stem Cell Biology (DSCB) Program is a broad, interdepartmental consortium of students and faculty pursuing developmental, stem cell, and regenerative biology research at the molecular, cellular, genetic, evolutionary, and systems levels. Researchers from across over 10 departments at Duke University and Duke School of Medicine participate. The mission of the DSCB PhD program is to train the next generation of predoctoral scientists in principles of development, stem cell biology, and regeneration through targeted coursework, lab research, and interactions within the DSCB community. The diverse backgrounds, research expertise, and perspectives of our community enable us to enrich and personalize the training environment. Our goal is to develop in our students: confidence, independent critical thinking, academic rigor, and the intellectual curiosity and creativity to synthesize new ideas and communicate them effectively. To accomplish this goal, we have devised a training plan which incorporates long-standing strengths of our 20 year program with new innovations to align with contemporary training. This includes a revised curriculum, required mentor training, and partnerships with new centralized offices at Duke focused on training biomedical researchers and enhancing diversity. Our plan incorporates education in core principles of development, stem cell biology and regeneration, as well as foundational education in genetics and molecular and cellular biology. Our students also gain training in data science principles, scientific communication, responsible conduct of research, and grant writing. This is achieved through a curriculum composed of modular course structure, innovative hands-on-training, and discussion based courses. Extensive laboratory training provides each student with expertise in a chosen specialty, and technical and conceptual scientific skillsets. Our trainees present their research at meetings and publish their research in journals, which builds their scientific communication skills. University-wide resources provide valuable professional resources and opportunities to help students develop their full potential to pursue a diversity of careers, and also provides platforms for tracking the progress of our students. We require mentor training and also train our students to be mentors. Our proposal seeks 10 annual training positions which will fund students in their second and third year of graduate school. Our 20 year old program has trained many scientists who have gone onto high-impact, research-related careers.

项目摘要 杜克大学开发和干细胞生物学（DSCB）计划是一个广泛的部门间财团 在分子上追求发展，干细胞和再生生物学研究的学生和教师， 细胞，遗传，进化和系统水平。来自杜克市10多个部门的研究人员 大学和杜克大学医学院参加。 DSCB博士计划的任务是培训下一个 通过开发原则，干细胞生物学原理和再生的产生 DSCB社区内的针对性课程，实验室研究和互动。不同的背景， 研究专业知识和社区的观点使我们能够丰富和个性化培训 环境。我们的目标是在学生中发展：信心，独立的批判性思维，学术严谨， 以及构成新思想并有效地传达新思想的智力好奇心和创造力。到 完成这个目标，我们制定了一个培训计划，该计划结合了我们20年的长期优势 计划具有新的创新，以与当代培训保持一致。这包括修订的课程，需要 导师培训以及与杜克大学新集中办事处的合作伙伴关系专注于培训生物医学 研究人员并增强多样性。 我们的计划将教育纳入发展，干细胞生物学和再生的核心原则 作为遗传学以及分子和细胞生物学的基础教育。我们的学生还接受数据培训 科学原则，科学沟通，负责任的研究和授予写作。这是实现的 通过由模块化课程结构，创新的动手培训和基于讨论的课程组成的课程 课程。广泛的实验室培训为每个学生提供所选专业和技术专业知识 和概念科学技能。我们的学员在会议上介绍他们的研究，并将其研究发表在 期刊，建立了他们的科学沟通技巧。大学范围的资源提供宝贵的资源 专业资源和机会，以帮助学生发挥全部潜力来追求多样性 职业，还提供了跟踪学生进步的平台。我们需要导师培训和 也训练我们的学生成为导师。我们的建议寻求10个年度培训职位，以资助学生 在研究生院的第二年和第三年。我们20岁的计划培训了许多科学家 从事与研究相关的高影响力的职业。

项目成果

Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue.

• DOI: 10.1016/j.devcel.2017.08.024
• 发表时间: 2017-09-25
• 期刊: Developmental cell
• 影响因子: 11.8
• 作者: Cao J;Wang J;Jackman CP;Cox AH;Trembley MA;Balowski JJ;Cox BD;De Simone A;Dickson AL;Di Talia S;Small EM;Kiehart DP;Bursac N;Poss KD
• 通讯作者: Poss KD

CRISPR Library Screening in Cultured Cardiomyocytes.

• DOI: 10.1007/978-1-0716-2261-2_1
• 发表时间: 2022
• 期刊: Methods in molecular biology (Clifton, N.J.)

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations.

• DOI: 10.1038/ng.2936
• 发表时间: 2014-05
• 期刊: Nature genetics
• 影响因子: 30.8
• 作者: Buczkowicz P;Hoeman C;Rakopoulos P;Pajovic S;Letourneau L;Dzamba M;Morrison A;Lewis P;Bouffet E;Bartels U;Zuccaro J;Agnihotri S;Ryall S;Barszczyk M;Chornenkyy Y;Bourgey M;Bourque G;Montpetit A;Cordero F;Castelo-Branco P;Mangerel J;Tabori U;Ho KC;Huang A;Taylor KR;Mackay A;Bendel AE;Nazarian J;Fangusaro JR;Karajannis MA;Zagzag D;Foreman NK;Donson A;Hegert JV;Smith A;Chan J;Lafay-Cousin L;Dunn S;Hukin J;Dunham C;Scheinemann K;Michaud J;Zelcer S;Ramsay D;Cain J;Brennan C;Souweidane MM;Jones C;Allis CD;Brudno M;Becher O;Hawkins C
• 通讯作者: Hawkins C

Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum.

发育中小脑增强子染色质可及性和 Zic 结合的调节。

• DOI: 10.1038/nn.3995
• 发表时间: 2015-05
• 期刊: NATURE NEUROSCIENCE
• 影响因子: 25
• 作者: Frank, Christopher L.;Liu, Fang;Wijayatunge, Ranjula;Song, Lingyun;Biegler, Matthew T.;Yang, Marty G.;Vockley, Christopher M.;Safi, Alexias;Gersbach, Charles A.;Crawford, Gregory E.;West, Anne E.
• 通讯作者: West, Anne E.

New insights from a high-resolution look at gastrulation in the sea urchin, Lytechinus variegatus.

• DOI: 10.1016/j.mod.2017.06.005
• 发表时间: 2017-12
• 期刊: Mechanisms of development
• 影响因子: 2.6
• 作者: Martik ML;McClay DR
• 通讯作者: McClay DR