CORE--BIOSTATISTICS AND BIOINFORMATICS

核心——生物统计学和生物信息学

• 批准号: 6783960
• 负责人: MOTOMI MORI
• 金额: $ 6.36万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6783960
• 关键词: Internet; aging; bioinformatics; biomedical facility; data management; experimental designs; immunosenescence; mathematical model; statistics /biometry

The Biostatistics & Bioinformatics Core (Core 9004) will provide biostatistics, bioinformatics and data management support to subprojects 0001-0004, Core 9002 and Core 9003. Specific aims of the Core 9004 are: (1) to provide data management support for Projects 0001-0004, Core 9002 and Core 9003; (2) to provide biostatistics and bioinformatics support to Core 9003 and microarray experiments proposed under Projects 0001, 0003 and 0004, and; (3) to provide biostatistical and mathematical modeling support to Projects 0001-0004. Under Specific Aim #1, Core 9004 will develop a PPG web portal, data storage, data use policies including data sharing and publishing. The PPG web portal will streamline data entry, verification, storage, and retrieval across four projects and cores. Under Specific Aim #2, Core 9004 will develop and implement a pre-processing and normalization protocol for Core 9003 as well as bioinformatics tools to efficiently retrieve and mine biological information from public databases. Further, Core 9004 will provide statistical analysis support for the microarray experiments and provide consultation on the design and analysis of the RT-PCR confirmation experiments. Under Specific Aim #3, Core 9004 will provide data analysis support for all experiments proposed under Projects 0001-0004 and assist the investigators with data interpretation and manuscript preparation. Core 9004 will develop mathematical and statistical models if necessary and incorporate recently published methods such as the analysis of lymphocyte kinetics and turnover.

生物统计和生物信息学核心（核心9004）将为子项目0001-0004、核心9002和核心9003提供生物统计学、生物信息学和数据管理支持。核心9004的具体目标是： (1) 为项目0001-0004、Core 9002和Core 9003提供数据管理支持； （2）为Core 9003和微阵列实验提供生物统计学和生物信息学支持 在项目 0001、0003 和 0004 下提议，以及； (3)为项目0001-0004提供生物统计和数学建模支持。 根据具体目标 1，Core 9004 将开发 PPG 门户网站、数据存储、数据使用政策（包括数据共享和发布）。 PPG 门户网站将简化四个项目和核心的数据输入、验证、存储和检索。根据具体目标#2，Core 9004将为Core 9003开发并实施预处理和标准化协议以及生物信息学工具，以从公共数据库中有效检索和挖掘生物信息。此外，Core 9004将为微阵列实验提供统计分析支持，并为RT-PCR确认实验的设计和分析提供咨询。根据具体目标#3，核心 9004 将为项目 0001-0004 下提出的所有实验提供数据分析支持，并协助研究人员进行数据解释和手稿准备。如有必要，Core 9004 将开发数学和统计模型 纳入最近发表的方法，例如淋巴细胞动力学和周转分析。