A novel formulation for combating biofilms and improving orthopaedic surgical wound healing

一种对抗生物膜和改善骨科手术伤口愈合的新型配方

• 批准号: 2905595
• 金额: --
• 依托单位: University of Surrey
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2905595
• 关键词: novel; formulation; combating; biofilms; improving

One of the most serious complications following orthopaedic surgery is the development of a deep surgical site infection (SSI) that is due to bacteria contamination from various sources including patients themselves and hospital. The bacteria can exist in planktonic form and in biofilms. The biofilm acts as a physical protective barrier of the bacteria from the penetration of antibodies, bacteriophages, granulocytes and biocides, antiseptics, antibiotics[1] and thus lead to the ineffectiveness of antibiotics and antimicrobial resistance (AMR). This project addresses these challenges through a holistic post surgery wound care approach: early-stage prophylactic intervention through the application of a novel formulation with multiple nutrients to prevent or control planktonic bacteria from proliferation and forming biofilms on both the implant and tissue surfaces. Secondly, this project explores the formulation's potential for the treatment of biofilm induced infection on the surgical site, if it occurs, through the formulation's enhanced biofilm penetration capability and killing resistant bacteria after the biofilm disintegration. Thirdly, certain compounds in the formulation can promote skin tissue regeneration once infection is kept at bay, which could potentially reduce the time taken for wounds recovery and minimise scar tissue formation.

骨科手术后最严重的并发症之一是发展深层手术部位感染（SSI），这是由于包括患者本身和医院在内的各种来源的细菌污染所致。细菌可以以浮游形式和生物膜存在。该生物膜可作为细菌的物理保护屏障，可在抗体，噬菌体，粒细胞和杀菌剂，抗菌素，抗生素[1]中渗透，从而导致抗生素和抗菌抗性（AMR）的无效性。该项目通过整体手术后伤口护理方法来应对这些挑战：通过在植入物和组织表面上使用多种营养的新型制剂，可预防或控制浮游生物细菌，以防止或控制浮游生物细菌，以预防或控制浮游生物细菌，从而解决这些挑战。其次，该项目通过配方增强的生物膜渗透能力，并在生物膜解体后杀死抗性细菌，探讨了手术部位上生物膜诱导感染的可能性的潜力。第三，配方中的某些化合物一旦感染避开，可以促进皮肤组织再生，这可能会减少伤口恢复所需的时间并最大程度地减少疤痕组织的形成。