Transmit/Receive Single Echo Acquisition MRI

发射/接收单回波采集 MRI

基本信息

批准号：
7267963
负责人：
Steven M Wright
金额：
$ 14.5万
依托单位：
TEXAS ENGINEERING EXPERIMENT STATION
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-01 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7267963
关键词：
Area Biochemistry Brain Calibration Catheters Depth Development Devices Diagnostic Diffusion Electronics Elements Evaluation Event Financial compensation Frequencies Functional Magnetic Resonance Imaging Future Gel Goals Image Imaging Techniques Industry Liquid substance Magnetic Resonance Imaging Measurement Measures Mechanics Methodology Methods Microfluidics Modeling Molecular Numbers Optics Pattern Penetration Phase Physiologic pulse Positioning Attribute Pulse taking Rate Relative (related person)Research Research Personnel Resolution Signal Transduction Slice Surface Techniques Technology Testing Thick Three-Dimensional Image Three-Dimensional Imaging Time Validation Wetting Agents Width analog base blood oxygenation level dependent response design drug development interest micro-total analysis system miniaturize programs response size tool voltage

项目摘要

DESCRIPTION (provided by applicant): The objective of this EBRG proposal is to develop Transmit/Receive Single Echo Acquisition (SEA) magnetic resonance imaging to enable imaging and flow measurements at extremely high temporal resolutions and over arbitrarily curved planes (linear only in the frequency encoding direction). The use of a T/R array will remove the need for a phase compensation pulse, a limitation in our earlier results using receive-only arrays. Therefore this new technique will be far more robust, enabling conformable arrays and 3D imaging. To achieve this objective, we will build a 64 channel, 30 watt per channel transmitter. In parallel, we will evaluate five candidate array element designs for optimal combination of penetration depth and decoupling, and then construct 64 channel planar and cylindrical arrays. Finally, we will develop, test, and evaluate T/R SEA MRI of flow using phase contrast and spin-tagging methods on conventional and microfluidic phantoms with periodic and non-periodic flow. If successful, this study will have developed a new methodology capable of MR imaging at unprecedented frame rates (500 frames/second) over arbitrarily curved slices. The method will provide a true "snapshot" flow imaging method, capable of imaging one-time events such as transient waves being investigated for MR elastography or non-periodic flow such as in stenotic vessel models. The conformable arrays will be applicable in catheter based interventional MRI and detecting rapid responses in fMRI of the brain surface. Of particular interest in this study is the use of T/R SEA flow measurement for characterization of microfluidic lab-on-a-chip devices. Methods are being investigated to create chaotic flow patterns in these devices, which can decrease mixing times by several orders of magnitude, critical for molecular diagnostics and drug development. The methods proposed here could provide a new tool for characterization of chaotic flow in these devices relying purely on endogenous contrast, eliminating the need for optical windows or seeding for optical reflection.

描述（由申请人提供）：该EBRG提案的目的是开发/接收单个回声采集（SEA）磁共振成像，以在极高的时间分辨率和过度任意弯曲的平面（仅在频率编码方向上线性线性）启用成像和流量测量值。使用T/R数组的使用将消除对相补偿脉冲的需求，这是我们使用仅接收阵列的早期结果的限制。因此，这项新技术将更加强大，可以实现合格的阵列和3D成像。为了实现这一目标，我们将构建一个每通道发射器30瓦的64通道。同时，我们将评估五个候选阵列元素设计，以最佳的渗透深度和脱钩，然后构建64个通道平面和圆柱阵列。最后，我们将使用具有周期性和非周期性流动的常规和微流体幻象上的相比对比度和自旋标记方法来开发，测试和评估流量的T/R SEA MRI。如果成功，这项研究将开发出一种新的方法，可以在任意弯曲的切片中以前所未有的帧速率（500帧/秒）进行MR成像。该方法将提供一种真正的“快照”流成像方法，能够成像一次性事件，例如正在研究MR弹性摄影或非周期性流量的瞬态波，例如stenotic血管模型。综合阵列将适用于基于导管的介入MRI，并检测大脑表面fMRI的快速反应。在这项研究中特别有趣的是使用T/R海流量测量来表征微流体实验室芯片设备。正在研究在这些设备中创建混沌流动模式的方法，这可以减少几个数量级的混合时间，这对于分子诊断和药物开发至关重要。这里提出的方法可以为这些设备中的混沌流动表征提供新工具，这些设备纯粹依靠内源性对比度，从而消除了光窗的需求或播种以进行光学反射。