To tax or not to tax? Parallels between chemotaxis and phoretic responses of bacterial spores

征税还是不征税？

• 批准号: 2904336
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2904336
• 关键词: tax; Parallels; between; chemotaxis; phoretic

Chemotaxis is the phenomenon that a cell's locomotion direction is determined by a gradient of one or more chemicals.[1] Understanding chemotaxis is relevant for many processes that control our well-being: inflammation, neuronal patterning, wound healing, tumor dissemination in cancer, and even embryogenesis. It is assumed that the molecular mechanisms that control fundamental aspects of chemotaxis appear to be evolutionarily conserved.[2] For this reason studies in lower eukaryotic models have helped massively to understand working principles, uncover molecular attractants and signalling substances and test a variety of chemotactic models and strategies.A recently developed setup allows the study of physical principles that lead to chemotaxis in simple artificial active matter[3] revealing phoretic principles that underly this phenomenon. How these principles might have affected early bacteria, giving some a slight evolutionary advantage which could have paved the way towards the development of most simple detection principles, has been rarely in the focus of research. Now, we aim at closing the loop by studying the behaviour of both, motile bacteria and their spores[4] in chemical gradients.

趋化性是细胞的运动方向由一种或多种化学物质的梯度决定的现象。 [1]了解趋化性与控制我们健康的许多过程相关：炎症、神经元模式、伤口愈合、癌症中的肿瘤传播，甚至胚胎发生。据推测，控制趋化性基本方面的分子机制似乎在进化上是保守的。 [2]因此，低等真核模型的研究极大地有助于理解工作原理，发现分子引诱剂和信号物质，并测试各种趋化模型和策略。最近开发的装置允许研究在简单的人工活性物质中导致趋化性的物理原理物质[3]揭示了这种现象背后的泳动原理。这些原理如何影响早期细菌，赋予某些细菌轻微的进化优势，从而为最简单的检测原理的发展铺平道路，但很少成为研究的焦点。现在，我们的目标是通过研究化学梯度中运动细菌及其孢子[4]的行为来闭合循环。