Functional Imaging of Decision Networks

决策网络的功能成像

• 批准号: 7198285
• 负责人: VINCENT P FERRERA
• 金额: $ 24.15万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7198285
• 关键词: Alzheimer' s Disease; Area; Attention; Attention Deficit Disorder; Behavior; Brain; Brain region; Categories; Cognition; Cognitive; Condition; Corpus striatum structure; Data; Decision Making; Dimensions; Feedback; Functional Imaging; Functional Magnetic Resonance Imaging; Goals; Human; Image; Literature; Maps; Monkeys; Motor; Parietal; Parkinson Disease; Pattern; Play; Pliability; Process; Psychophysiology; Research; Response to stimulus physiology; Role; Schizophrenia; Signal Transduction; Speed; Stimulus; Task Performances; Testing; Training; Uncertainty; Visual Fields; Visual Psychophysics; Work; abstracting; awake; base; blood oxygen level dependent; design; human subject; inferotemporal cortex; neurophysiology; nonhuman primate; oculomotor; research study; response; superior colliculus Corpora quadrigemina; visual stimulus

DESCRIPTION (provided by applicant): The ability to make decisions based on abstract categories is a fundamental component of higher-order cognition and is essential for survival. In the past decade, much progress in understanding categorical decision-making has been made through the combination of visual psychophysics and single-unit neurophysiology in awake, behaving monkeys. This work has led to a clearer understanding of decision networks in parietal, frontal and inferotemporal cortex. However, two very basic questions remain unresolved. First, how does activity in specific brain regions targeted by single unit studies relate to the overall pattern of brain activation when monkeys are engaged in decision-making tasks? What additional regions also are involved in processing such decisions, and what role do such regions play? Second, are results from non-human primates applicable to humans? Specifically, given identical psychophysical tasks, can we establish functional homology between human and non-human primate brains? To answer these questions, we propose to use functional magnetic resonance imaging in awake behaving monkeys to map brain regions that are activated during a perceptual categorization task, using a paradigm identical to one used with human subjects. The proposed experiments will open up a new avenue of research into cognitive processes that are dramatically impaired in schizophrenia, attention-deficit disorder, Parkinson's disease, and Alzheimer's disease.

描述（由申请人提供）：基于抽象类别做出决策的能力是高阶认知的基本组成部分，对于生存至关重要。在过去的十年中，通过视觉心理物理学和单个单元神经生理学的结合，在醒着，表现出猴子的情况下，已经取得了很大的进步。这项工作使人们对顶叶，额叶和颞叶皮质的决策网络有了更清晰的了解。但是，两个非常基本的问题仍未解决。首先，单位研究针对的特定大脑区域的活动与猴子从事决策任务时的整体大脑激活模式如何？处理此类决策还涉及哪些其他区域，此类地区的角色扮演什么角色？其次，是否适用于人类的非人类灵长类动物的结果？具体而言，鉴于相同的心理物理任务，我们可以在人类和非人类灵长类动物的大脑之间建立功能同源吗？为了回答这些问题，我们建议在醒着的行为猴子中使用功能磁共振成像来绘制在感知分类任务中被激活的大脑区域，使用与与人类受试者使用的范式相同的范式。拟议的实验将为认知过程开辟新的研究途径，这些研究在精神分裂症，注意缺陷障碍，帕金森氏病和阿尔茨海默氏病中受到极大损害。