Physicochemical characterisation of oligonucleotides for therapeutic formulations

用于治疗制剂的寡核苷酸的物理化学表征

• 批准号: 2902101
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2902101
• 关键词: Physicochemical; characterisation; oligonucleotides; therapeutic; formulations

While oligonucleotides are promising therapeutics, their formulation is challenging because of their considerable and unpredictable viscosity at higher concentrations which is an obstacle to delivery by injection. Using a range of physicochemical analysis tools to study inter- and intramolecular interactions, this project aims to generate fundamental understanding of how oligonucleotide viscosity is related to their physicochemical properties and apply this knowledge to control oligonucleotide formulation viscosity, enabling delivery of these promising compounds as injectable medicines.

虽然寡核苷酸是有前途的治疗方法，但其配方具有挑战性，因为它们在较高浓度下具有相当大且不可预测的粘度，这阻碍了注射递送。该项目使用一系列理化分析工具来研究分子间和分子内相互作用，旨在对寡核苷酸粘度与其理化性质之间的关系产生基本了解，并应用这些知识来控制寡核苷酸制剂粘度，从而能够以注射剂的形式提供这些有前途的化合物药物。