Development of high-value chemicals bioproduction integrating metabolic engineering, Design of Experiments and entrepreneurship

结合代谢工程、实验设计和创业精神开发高价值化学品生物生产

• 批准号: 2898855
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2898855
• 关键词: Development; value; chemicals; bioproduction; integrating

The use of genetically engineered strains to biomanufacture chemicals enables direct CO2-to-product systems with vastly superior environmental sustainability (reduced GHGe) and synthesisof isomer(s) with a purity not achieved by traditional chemistry. However, the engineering andoptimization of microbial bioproduction strains (essential components in the development ofbiological manufacturing systems) is time-consuming and costly. Coupled with the uncertainty ofbiological engineering, this leads to higher risk and a lower appetite for investment, makingcommercialisation challenging. To enable SynBio to make a meaningful contribution to theenormous fossil fuel problem, we propose to first commence with higher value beachhead targetproducts and solve current bottlenecks to developing viable solutions.

基因工程菌株在生物制造化学物质中的使用实现了直接的二氧化碳到产品系统，具有较高的环境可持续性（减少的GHGE）和异构体合成，并且无法通过传统化学实现纯度。但是，微生物生物生产菌株（生物制造系统开发中的重要组成部分）的工程和优化是耗时且昂贵的。再加上生物学工程的不确定性，这会导致更高的风险和较低的投资需求，使商业化具有挑战性。为了使Synbio能够为Omoformus化石燃料问题做出有意义的贡献，我们建议首先从价值更高的Beachhead Target Products开始，并将目前的瓶颈解决为开发可行的解决方案。