Program in Molecular and Cellular Biosciences

分子和细胞生物科学项目

• 批准号: 7252601
• 负责人: Gary Thomas
• 金额: $ 20.81万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7252601
• 关键词: Molecular; programs

DESCRIPTION (provided by applicant): This application requests funds to support the training of predoctoral students in the Program in Molecular and Cellular Biosciences (PMCB) at Oregon Health & Science University. This interdisciplinary program brings together 175 faculty members from five basic science departments (Biochemistry and Molecular Biology, Cell and Developmental Biology, Molecular and Medical Genetics, Molecular Microbiology and Immunology, and Physiology and Pharmacology) and affiliated research institutes to provide first- and second-year graduate students with the theoretical and laboratory foundation they require to become successful research scientists. This proposal will support six Ph.D. students out of the 119 currently enrolled in the PMCB for their first two years of training. The 80-member training faculty members in this application are internationally recognized for their expertise in biophysical, molecular, cellular, and developmental approaches to important and compelling biological questions using state-of-the art methodologies. Notably, graduate students also directly participate in ground-breaking translational research, ranging from the development of the first small molecule inhibitor of cancer (Gleevec) to the first liver stem cell therapy, the molecular basis of obesity, and the development of new vaccines for emerging pathogens. Our program offers qualified students a common, rigorous didactic grounding for the first year, and continued grounding as students begin to specialize during their second year. Students also participate in seminar series, program retreats, teaching, and may attend scientific meetings. Students must successfully pass a comprehensive written exam at the end of their first year and a qualifying exam at the end of their second year, in which they prepare and defend an original research proposal. Subsequently, students are formally admitted to one of the five participating departments to conduct a research project leading to the awarding of a Doctorate of Philosophy. Importantly, the dynamic research community at OHSU, combined with the proximity of basic and clinical research facilities, provide a unique opportunity for Ph.D. students to form cross-discipline collaborations during their training and to gain an appreciation of the health-relatedness of the basic science research that they undertake.

描述（由申请人提供）：本申请要求资金支持俄勒冈健康与科学大学分子和细胞生物科学 (PMCB) 项目博士前学生的培训。这个跨学科项目汇集了来自五个基础科学系（生物化学与分子生物学、细胞与发育生物学、分子与医学遗传学、分子微生物学与免疫学、生理学与药理学）和附属研究机构的 175 名教职人员，提供第一和第二-一年级研究生，具备成为成功的研究科学家所需的理论和实验室基础。该提案将支持六名博士生。目前在 PMCB 注册参加前两年培训的 119 名学生中。该应用程序中的 80 名培训教员因其在生物物理、分子、细胞和发育方法方面的专业知识而获得国际认可，这些方法使用最先进的方法来解决重要且引人注目的生物学问题。值得注意的是，研究生还直接参与突破性的转化研究，从第一个小分子癌症抑制剂（格列卫）的开发到第一个肝脏干细胞疗法、肥胖的分子基础以及新疫苗的开发新出现的病原体。我们的课程为合格的学生在第一年提供通用、严格的教学基础，并在第二年为学生开始专业化提供持续的基础。学生还可以参加系列研讨会、项目静修、教学，并可以参加科学会议。学生必须在第一年末成功通过综合笔试，并在第二年末成功通过资格考试，在考试中他们要准备并捍卫原创的研究计划。随后，学生被正式录取到五个参与院系之一进行研究项目，最终获得哲学博士学位。重要的是，OHSU 充满活力的研究社区，加上邻近的基础和临床研究设施，为博士生提供了独特的机会。学生在培训期间形成跨学科合作，并了解他们所从事的基础科学研究与健康的相关性。