Mononuclear phagocyte activi in cochlea acoustic trauma

耳蜗声损伤中的单核吞噬细胞活性

基本信息

批准号：
7171581
负责人：
Keiko Hirose
金额：
$ 16.13万
依托单位：
CLEVELAND CLINIC LERNER COM-CWRU
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-12-05 至 2007-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7171581
关键词：
Acoustic Trauma Acoustics Address Appearance Bromodeoxyuridine CD45 Antigens Caring Cell Count Cell Proliferation Cells Chairperson Chemotactic Factors Classification Clinic Cochlea Communication impairment Communities Development Disease Doctor of Medicine Ear Electronic Mail Electrons Environment Epithelium Exhibits Exposure to Fever Foundations Genetic Transcription Goals Grant Histologic Immunohistochemistry In Situ Individual Inflammation Injury Institution Interleukin-1 Interleukin-6 Investigation K-Series Research Career Programs Knock-out Knockout Mice Label Labyrinth Leukocytes Ligands Light Location Macrophage Activation Maps Marshal Membrane Mentors Messenger RNA Microglia Microscopic Mission Monocyte Chemoattractant Protein-1 Mononuclear Mus Myelogenous Myeloid Cells Natural regeneration Neuraxis Neurodegenerative Disorders Neuroglia Neurosciences Noise Normal Cell Numbers Ohio Otolaryngology Outcome PTPRC gene Pathogenesis Pattern Peripheral Peripheral Nervous System Phagocytes Phagocytosis Phase Physicians Physiological Polymerase Chain Reaction Population Principal Investigator Process Production Program Research Project Grants Proliferating Proteins Recovery Recruitment Activity Reporting Research Institute Research Personnel Reverse Transcription Role Scientist Sensory Staining method Stains Swelling TNF gene Telefacsimile Testing Time Tissues Vascular Permeabilities Vascular blood supply Work career cell injury cell type chemokine receptor cytokine health care quality macrophage medical schools migration monocyte neuroimmunology professor programs receptor repaired response

项目摘要

Marshall Strome, M.D., M.S., F.A.C.S. Chairman and Professor of Otolaryngology Department of Otolaryngology and Communicative Disorders / A71 Office: 216/444-6686 Fax: 216/445-9409 E-mail: stromem@ccf org Environmental and institutional commitment to the candidate Description of Institutional Environment The Cleveland Clinic Foundation is a institution dedicated to providing the best care for the sick and to promote investigation of illness. The Lerner Research Institute was developed in order to expand our basic understandings of the mechanisms of disease processes and to recruit and retain individuals who will make a significant impact on the quality of health care in the years to come. Promoting the career development of physician researchers is therefore a critical part of the mission of this institution. The Department of Neurosciences at the Lerner Research Institute (LRI) is widely recognized for its expertise in the field of neuroimmunology and pathogenesis of neurodegenerative diseases. Dr. Bruce Trapp is the chairman of the Department of Neurosciences and has mentored previous physician-scientists who have obtained K award grants at the Cleveland Clinic Foundation. His expertise in the field of axonal and glial cell degeneration and inflammation in the peripheral and central nervous system is recognized throughout the neuroscience community internationally and is extensively supported by three R01 grants, a program project grant and numerous private foundation grants. Dr. Trapp has demonstrated his ability to mentor successful physician scientists, both at the Cleveland Clinic Foundation and previously at Johns Hopkins School of Medicine, and he is ideally suited to providing guidance and support as well 26 950¿) Euclid Avenue, Cleveland, Ohio 44195

马歇尔·斯特罗姆 (Marshall Strome)，医学博士、理学硕士、F.A.C.S. 耳鼻喉科主任兼教授耳鼻喉科和沟通障碍/A71 办公室：216/444-6686 传真：216/445-9409 电子邮件：stromem@ccf org 对候选人的环境和制度承诺制度环境描述克利夫兰诊所基金会是一个致力于提供最佳服务的机构照顾病人并促进疾病调查。研究所的成立是为了扩大我们对疾病过程的机制，并招募和留住能够对未来几年的医疗保健质量产生重大影响。因此，促进医师研究人员的职业发展至关重要该机构使命的一部分。勒纳研究所 (LRI) 的神经科学系广泛因其在神经免疫学和发病机制领域的专业知识而受到认可布鲁斯·特拉普博士是神经退行性疾病科主任。神经科学博士，并指导过以前的医学科学家他在克利夫兰诊所基金会获得了 K 奖资助。外周和神经胶质细胞变性和炎症的领域中枢神经系统在整个神经科学界得到认可国际上并得到三项 R01 赠款的广泛支持，该计划特拉普博士获得了项目资助和众多私人基金会资助。他指导成功的医学科学家的能力，都在克利夫兰诊所基金会和之前在约翰霍普金斯大学医学，他也非常适合提供指导和支持 26 950€ ）欧几里得大道，克利夫兰，俄亥俄州 44195