Chemokines and their receptors in the pathogenesis of tuberculosis

结核病发病机制中的趋化因子及其受体

• 批准号: 7319375
• 负责人: GILLIAN L BEAMER
• 金额: $ 10.88万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7319375
• 关键词: Adoptive Transfer; Anatomy; Antigens; Appointment; Arts; Award; Biology; Biomedical Research; CCL3 gene; CCL4 gene; CCR1 gene; CCR5 gene; Cells; Cessation of life; Chronic; Communicable Diseases; Core Facility; Data; Development Plans; Disease; Doctor of Philosophy; Eligibility Determination; Environment; Event; Faculty; Funding; Generations; Goals; Granuloma; Growth; Health; Immune; Immunity; Immunologics; In Vitro; Infection; Job Application; Joints; Kinetics; Knock-out; Knockout Mice; Licensing; Localized; Lung; Lymphocyte; Maintenance; Mediastinal lymph node group; Mediating; Mentors; Migration Assay; Mouse Strains; Mus; Mycobacterium tuberculosis; Ohio; Pathogenesis; Pathology; Play; Positioning Attribute; Predisposition; Production; RANTES; Recording of previous events; Recruitment Activity; Research; Research Personnel; Resistance; Role; Scientist; Site; Source; Structure; Structure of parenchyma of lung; T-Lymphocyte; Testing; Time; Training; Training Programs; Tuberculosis; Universities; Veterinarians; Wild Type Mouse; acquired immunity; base; career; cell growth; cell motility; cell type; chemokine; chemokine receptor; experience; in vivo; lymph nodes; macrophage; member; microbial; migration; programs; pulmonary granuloma; receptor; receptor structure function; response; success

DESCRIPTION (provided by applicant): THE CANDIDATE: Dr. Gillian Beamer, a licensed veterinarian with board-eligibility in veterinary anatomic pathology, is completing a PhD training program at The Ohio State University (OSU). This K08 MSCDA will support her accelerated transition to scientific independence. THE ENVIRONMENT: OSU's Division of Infectious Diseases and Department of Veterinary Biosciences (VBS) are large, well funded biomedical research centers with faculty, state-of-the-art core facilities and a history of effectively training clinician scientists. THE MENTORS: Dr. Joanne Turner and Dr. Larry Schlesinger are faculty members with joint appointments in the Center for Microbial Interface Biology (CMIB) and VBS. Both mentors are highly experienced in tuberculosis research and both are dedicated to the success of the candidate. THE TRAINING PLAN: The 4-year career development plan will accelerate Dr. Beamer's transition to scientific independence. Upon PhD completion and K08 award, she will be immediately eligible for job application and a highly valued candidate for staff scientist positions. The plan includes a short overlapping period for supervised PhD completion followed by the mentored projects outlined in the research plan. Mentoring will be substantially focused during the first 2 years of the award; in the last 2 years, contact will be maintained at a reduced level to facilitate scientific growth. THE PROPOSAL: Granuloma formation in the lungs is required to control M.tb growth. The mechanisms of cellular recruitment to form granulomas, however, are not fully known. Powerful chemoattractant cytokines (chemokines) and their receptors may play vital roles in granuloma formation and maintenance by orchestrating migration of T cells to sites of infection. In this proposal, we will determine the role of chemokines, immunologic consequences and mechanisms of T cell recruitment to granulomas in response to M.tb lung infection in vivo. Defining essential criteria for M.tb granuloma formation will further our understanding of the requirements for the generation of protective immunity.

描述（由申请人提供）：候选人：吉利安·比默（Gillian Beamer）博士是一名有执照的兽医，具有董事会资格的兽医解剖病理学，正在俄亥俄州立大学（OSU）完成博士学位培训计划。这个K08 MSCDA将支持她加速向科学独立的过渡。环境：OSU的传染病和兽医生物科学系（VBS）是大型，资助良好的生物医学研究中心，该中心具有教职员工，最先进的核心设施以及有效培训临床医生的历史。导师：乔安妮·特纳（Joanne Turner）博士和拉里·施莱辛格（Larry Schlesinger）博士是在微生物界面生物学中心（CMIB）和VBS联合任命的教职员工。两位导师在结核病研究中均经验丰富，并且两者都致力于候选人的成功。培训计划：为期4年的职业发展计划将加速Beamer博士向科学独立的过渡。博士学位完成和K08奖后，她将立即有资格获得工作申请，并成为员工科学家职位的高度重视候选人。该计划包括一个简短的重叠期，以完成监督的博士完成，然后是研究计划中概述的指导项目。在奖项的前两年中，指导将大大关注；在过去的两年中，接触将保持降低的水平，以促进科学生长。提案：需要肺部的肉芽肿形成才能控制M.TB生长。然而，细胞募集的机制尚不清楚。强大的趋化剂细胞因子（趋化因子）及其受体可能通过策划T细胞向感染部位的迁移而在肉芽瘤形成和维持中起着至关重要的作用。在该提案中，我们将确定趋化因子，免疫学后果和T细胞募集到肉芽肿的机制对体内M.TB肺部感染的作用。定义M.TB肉芽肿的基本标准将进一步理解生成保护性免疫的要求。