Genetic-based susceptibility to pulmonary tuberculosis

肺结核的遗传易感性

基本信息

批准号：
8807082
负责人：
GILLIAN L BEAMER
金额：
$ 26.33万
依托单位：
TUFTS UNIVERSITY BOSTON
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-15 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8807082
关键词：
Aerosols Analysis of Variance Antibiotic Resistance Antibiotics Bacillus (bacterium)Biological Body Weight Candidate Disease Gene Cause of Death Cessation of life Chromosome Mapping Classification Complex Computational algorithm Computer Simulation Computer software Data Data Set Disease Environmental Risk Factor Experimental Models Foundations Future Genes Genetic Genetic Variation Genotype Goals Granuloma Graph Histologic Human Image Immune Immune response Immunity Inbreeding Infection Knowledge Laboratory mice Light Location Lung Lymphocyte Maps Microscopic Microscopy Mining Modeling Molecular Genetics Morbidity - disease rate Mouse Strains Mus Mycobacterium tuberculosis Necrosis Neutrophil Infiltration Newly Diagnosed Outcome Pathologic Pathologist Pathway interactions Pattern Phenotype Population Population Heterogeneity Predisposition Prevention Process Pulmonary Tuberculosis Research Resolution Source Susceptibility Gene System Techniques Testing Texture Therapeutic Tuberculosis Vaccination Validation Virulent Work bacterial genetics base improved innovation killings macrophage mortality multidisciplinary neutrophil novel pathogen public health relevance pulmonary granuloma response time use trait transmission process tuberculosis granuloma

项目摘要

DESCRIPTION (provided by applicant): Tuberculosis (TB), the disease due to Mycobacterium tuberculosis (M.tb) is the leading cause of death due to a single pathogen, killing 1-2 million and newly diagnosed in 8-9 million people each year. By far, the most common form of TB develops in the lungs. Pulmonary TB occurs in the face of intact host immunity and has distinctive pathologic phenotypic traits including granuloma necrosis, neutrophil influx, and cavitation. Here, for the first time, we use Diversity Outbred (DO) mice, to help understand how host genetics influence pulmonary TB. We hypothesize that granuloma-specific phenotypes of pulmonary TB reflect pathways of genetic control. We use an innovative multidisciplinary systems approach to capture, quantify, and analyze biologically relevant disease features of pulmonary TB. The results from this proposal will yield novel information regarding pulmonary TB in genetically diverse populations. Results from these studies will also provide the foundation for future, more extensive work determining predictive signatures of disease, therapeutic, and vaccination responses.

描述（由申请人证明）：结核病（TB），由于造成死亡病原体的主要原因，杀死了1-200万和迄今为止，最常见的结核病形式在肺部出现了8-9万人。 do）小鼠，为了了解宿主遗传学的遗传学肺结核。关于遗传多样性的肺结核的。