Precise MRI-Directed Sonic Ablation of Prostate Cancer

前列腺癌的精确 MRI 引导声波消融

• 批准号: 7162906
• 负责人: FRANK GRAHAM SOMMER
• 金额: $ 43.57万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-13 至 2008-05-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162906
• 关键词: Ablation; Acoustics; Aftercare; Anogenital region; Canis familiaris; Catheters; Chronic; Clinical; Clinical Trials; Compatible; Computer Simulation; Data; Development; Devices; Dose; Effectiveness; Environment; Evaluation; Funding; Genetic Crossing Over; Goals; Grant; Heating; Histologic; Image; Imaging Techniques; Immune; Injury; Magnetic Resonance; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of prostate; Maps; Measurement; Mechanics; Modeling; Monitor; Motion; Motor; Necrosis; Normal tissue morphology; Patients; Pattern; Performance; Periprostatic; Phase; Placement; Procedures; Prostate; Prostate Ablation; Prostate carcinoma; Prostatic; Prostatic Tissue; Protocols documentation; Purpose; Real-Time Systems; Rectum; Research; Research Design; Research Project Grants; Resected; Safety; Series; Speed; System; Techniques; Technology; Temperature; Testing; Thermal Ablation Therapy; Time; Tissues; Transducers; Translating; Treatment Protocols; Ultrasonics; Ultrasonography; Urethra; Water; Work; base; day; design; improved; in vivo; interstitial; prevent; rectal; research study; tissue phantom

DESCRIPTION (provided by applicant): The overall goal of the research will be to build on our progress in creating an integrated system for ablation of prostatic tissue incorporated advanced designs for the ablation prostate tissue, and ultimately prostatic carcinoma, in a rapid, precise fashion under MRI guidance. Applicators will either be directly inserted into the prostate gland through the perineum (interstitial applicators) of through the urethra (transurethral). Several new designs for transurethral applicators, designed to maximize speed and precision of treatment will be designed and tested. A system to perform automated rotational and linear mechanical control of applicators during in vivo treatments will be constructed. Systems for preventing rectal injury, including a endorectal cooling system using circulating water, and procedures for providing acoustic blocking between the prostate and rectum will be further developed. Further enhancements to our successful system for MR temperature imaging (MRTI) will be achieved using a referenceless approach, 3 point Dixon, multiple readouts per TR, and phased array imaging to create an optimal real-time system for monitoring of ablation. The research plan envisages a heirarchical series of experiments, with initial development and testing of all the component technologies described above, to be followed by extensive in vivo studies of prostate ablation in a canine model. In these experiments, different applicators and protocols will be tested and compared for performance in performing rapid, controlled ablation. MRTI techniques will be tested in these trials as well, with correlative thermocouple monitoring to assess accuracy. Improved histologic analysis techniques for resected prostate glands and periprostatic tissues following treatments will allow accurate correlation of MRTI data and post-treatment MR images, and a chronic model of prostatic ablation (7 or more days) will be assessed. At the completion of this work, we plan to have completely defined an integrated system suitable for clinical ablation of prostatic tissue and prostate cancer.

描述（由申请人提供）：该研究的总体目标是建立我们在建立综合系统的进步基础上，以融合前列腺融合的前列腺组织的高级设计，并最终以MRI指南快速，精确的方式来制定前列腺癌。通过尿道（经尿道），涂抹器要么通过会阴（间质施加器）直接插入前列腺。将设计和测试用于最大化速度和治疗精度的几种新设计的新设计。将构建一个在体内处理过程中对涂抹器进行自动旋转和线性机械控制的系统。预防直肠损伤的系统，包括使用循环水的内直肠冷却系统，以及在前列腺和直肠之间提供声学阻滞的程序。使用无引用方法，3点Dixon，每TR的多个读数和分阶段阵列成像，可以实现我们成功的MR温度成像系统（MRTI）的进一步增强，以创建一个最佳的实时系统来监视消融。该研究计划设想了一系列继承人的实验，并对上述所有组件技术进行了初步开发和测试，随后将在犬模型中对前列腺消融的体内进行广泛的研究。在这些实验中，将测试不同的施加器和协议，并比较执行快速，受控消融的性能。 MRTI技术也将在这些试验中进行测试，并通过相关热电偶监测以评估准确性。治疗后切除的前列腺和腹膜组织的改进的组织学分析技术将允许MRTI数据和处理后MR图像准确相关，并评估前列腺消融的慢性模型（7天或更多天）。这项工作完成时，我们计划完全定义一个适合前列腺组织和前列腺癌临床消融的集成系统。