Brain anatomical correlates of mobility control in the oldest old

大脑解剖学与老年人活动控制的相关性

• 批准号: 7319342
• 负责人: Caterina Rosano
• 金额: $ 58.7万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7319342
• 关键词: Address; African American; Age; Aged, 80 and over; Aging; Aging-Related Process; Area; Arthralgia; Atrophic; Attenuated; Basal Ganglia; Biological Neural Networks; Blood Pressure; Blood Vessels; Body Composition; Body mass index; Brain; Brodmann' s area; Cardiopulmonary; Cardiovascular system; Cells; Cerebellum; Cognition; Cognitive; Cohort Studies; Communities; Cross-Sectional Studies; Data Collection; Dementia; Diffusion Magnetic Resonance Imaging; Elderly; Equilibrium; Funding; Gait; Goals; Health; Imaging Techniques; Impairment; Inflammatory; Internal Capsule; Knowledge; Label; Limb structure; Link; Lobule; Localized; Location; Lower Extremity; Magnetic Resonance Imaging; Measures; Methods; Musculoskeletal; Natural History; Nature; Neuraxis; Neurological status; Neurons; Numbers; Parietal; Parkinson Disease; Participant; Pathogenesis; Pathway interactions; Pattern; Peripheral; Personal Satisfaction; Phase; Physical activity; Prefrontal Cortex; Pulmonary Heart Disease; Rate; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Risk Factors; Severities; Spatial Distribution; Speed; Strategic Planning; Stroke; Structure; Time; Women' s Health; Work; age related; cardiovascular risk factor; cohort; follow-up; frontal lobe; gray matter; insight; muscle strength; nervous system disorder; programs; putamen; white matter

DESCRIPTION (provided by applicant): Community-dwelling older adults often report mobility impairment linked with multifactorial changes in the cardiopulmonary, musculoskeletal, peripheral and central nervous systems. There is strong emergent evidence that white matter (WM) hyperintensities are associated with lower-extremity mobility limitations independent of other factors. Dr. Rosano has recently discovered that impaired speed and balance are associated with focal grey matter (GM) atrophy of specific mobility-related regions. This longitudinal epidemiological project aims to investigate the longitudinal association of focal brain magnetic resonance imaging (MRI) abnormalities in GM and WM with age-related mobility impairment in gait speed and balance in a large cohort of community-dwelling older adults from the Health Aging Body Composition Study (Health ABC). This proposal builds onto the current ongoing Healthy Brain Project (K23AG028966-01, PI: Dr Rosano), which is a descriptive cross-sectional study of the association between quantitative brain MRIs measures and mobility in 250 participants of the Health ABC cohort. The new study that we propose will increase the power to detect important effects via the acquisition of additional 148 MRIs and will provide further longitudinal insights into the impact of brain MRI abnormalities on the natural history of mobility impairment by adding a follow up time of 3 years after completion of brain MRI. Thus, this proposal is uniquely timed to capture important information during the planned data collection phase of the Health ABC Study in 2006-2007. This project uses automated volumetric methods, magnetization transfer and diffusion tensor imaging to measure severity and location of GM and WM abnormalities. The aims of this project are: 1. To examine the longitudinal association of focal regional GM and WM tracts abnormalities with worsening mobility and specifically with gait speed and balance. 2. To examine the combined effect of groups of GM/ WM abnormalities on worsening speed and balance. 3. To determine the longitudinal association of cardiovascular risk factors with focal GM and WM abnormalities in mobility-related regions and tracts. The results of this project will advance our knowledge of the pathogenesis of mobility impairment in community-dwelling older adults and will lay the ground work for further studies of age-related changes of the neural networks involved in mobility control, for example using functional brain MRI studies.

描述（由申请人提供）：居住在社区的老年人经常报告与心肺，肌肉骨骼，周围和中枢神经系统多因素变化有关的活动障碍。有强烈的紧急证据表明，白质（WM）高强度与独立于其他因素无关的较低肢体迁移率限制有关。罗萨诺（Rosano）博士最近发现，速度和平衡受损与特定迁移率相关区域的局灶性灰质（GM）萎缩有关。这个纵向流行病学项目旨在调查GM和WM中局灶性脑磁共振成像（MRI）异常的纵向关联，而年龄相关的移动性障碍在步态速度和平衡中，来自大量社区居住的老年人，来自健康阶段的老年人。组成研究（健康ABC）。该提案建立在当前正在进行的健康脑项目（K23AG028966-01，PI：Rosano博士）的基础上，这是对定量脑MRIS测量和迁移率之间的相关性描述性横截面研究。我们提出的新研究将通过获取额外的148 MRI来提高检测重要效果的能力，并将通过增加3年的随访时间为3年，从而提供进一步的纵向见解。完成大脑MRI后。因此，在2006 - 2007年卫生ABC研究计划的数据收集阶段，该提案是唯一的定时时间来捕获重要信息。该项目使用自动体积方法，磁化转移和扩散张量成像来测量GM和WM异常的严重性和位置。该项目的目的是：1。检查焦点区域GM和WM区域异常的纵向关联，而迁移率恶化，特别是步态速度和平衡。 2。检查GM/ WM异常组对速度和平衡恶化的综合作用。 3。确定心血管危险因素与局灶性GM和WM异常的纵向关联。该项目的结果将促进我们对社区居民老年人流动性障碍发病机理的了解，并将为对流动性控制涉及的神经网络的年龄相关变化进行进一步研究，例如使用功能性大脑MRI研究。