Epidemiology and Biostatistics of Aging

老龄化流行病学和生物统计学

• 批准号: 7228169
• 负责人: LINDA P FRIED
• 金额: $ 46.92万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7228169
• 关键词: Epidemiology; Biostatistics; Aging

DESCRIPTION (provided by applicant): This is an application for a 5-year renewal of an institutional training grant in the Epidemiology and Biostatistics of Aging, funded by NIA since 1996. This multidisciplinary training program's goals are to train outstanding predoctoral and postdoctoral candidates to lead the next generation of quantitative research scientists addressing the health problems of our aging population. This program is conducted jointly by epidemiologists and biostatisticians with a strong commitment to bringing together students in both disciplines to develop expertise in both the content areas and methodologies that are essential to the further development of the field. Students are trained as researchers who can conduct leading-edge descriptive, analytic and experimental studies and develop, implement and evaluate prevention programs to compress the morbidity experience of the aging population. The program is based in the Departments of Epidemiology and Biostatistics, but involves faculty from other departments throughout the Schools of Public Health, Medicine, and Nursing. A Program Director in Epidemiology, a Co-Director from Biostatistics, 5 Associate Directors from the two Departments, and 21 other core faculty members will serve as Advisors for the trainees. There is a core curriculum expected of predoctoral trainees, and customized to postdoctoral trainees. Trainees, half Epidemiology and half from Biostatistics, participate in biweekly research in progress conferences, seminars on aging, and practica specific to this program, and training dedicated to skills in multidisciplinary collaboration. Research experiences and mentors are selected to ensure high quality research worthy of peer-reviewed publication in aging research. We propose to continue to train students in epidemiologic and biostatistical method, and their application to important questions in the health status of older adults, including causes and consequences of chronic diseases, comorbidity, and disability. Students develop expertise in design and conduct of large-scale observational prospective studies; longitudinal data analysis; the genetic and molecular causes of age-related changes; the phenotype, consequences and etiology of frailty, and cognitive decline; statistical methods for the measurement and analysis of complex geriatric outcomes, such as frailty and disability; the social epidemiology of aging; and programs that translate research findings into effective prevention for older adults. We now propose to enrich and expand the emphases to include study in the design and conduct of clinical trials in older populations and the integration of physiology into longitudinal epidemiologic studies of the progression of health and disease. Trainees have been highly productive, gained substantial recognition for their research, and launched their careers in appealing positions with emphases on aging. Graduates will be effective leaders of multidisciplinary research teams tackling the health problems associated with the aging US population.

描述（由申请人提供）：这是一份关于老龄化流行病学和生物统计学机构培训补助金续签 5 年的申请，自 1996 年起由 NIA 资助。这个多学科培训项目的目标是培养优秀的博士前和博士后候选人领导下一代定量研究科学家解决人口老龄化的健康问题。该计划由流行病学家和生物统计学家联合开展，致力于将两个学科的学生聚集在一起，发展对该领域进一步发展至关重要的内容领域和方法的专业知识。学生被培训为研究人员，能够进行前沿的描述性、分析性和实验性研究，并制定、实施和评估预防计划，以减少老龄化人口的发病率。该项目以流行病学和生物统计学系为基础，但也包括公共卫生学院、医学院和护理学院其他系的教师。一名流行病学专业主任、一名生物统计学副主任、两个系的五名副主任以及其他21名核心教员将担任学员的顾问。有针对博士前培训生的核心课程，并为博士后培训生定制。受训者一半来自流行病学，一半来自生物统计学，参加每两周一次的进展会议研究、老龄化研讨会和针对该项目的实践，以及专门针对多学科合作技能的培训。选择研究经验和导师是为了确保高质量的研究值得在老龄化研究领域进行同行评审的出版物。我们建议继续对学生进行流行病学和生物统计学方法的培训，并将其应用于老年人健康状况的重要问题，包括慢性病、合并症和残疾的原因和后果。学生培养设计和进行大规模观察性前瞻性研究的专业知识；纵向数据分析；年龄相关变化的遗传和分子原因；虚弱和认知能力下降的表型、后果和病因；用于测量和分析复杂的老年病结果（例如虚弱和残疾）的统计方法；老龄化社会流行病学；以及将研究成果转化为老年人有效预防的计划。我们现在建议丰富和扩展重点，包括在老年人群中设计和进行临床试验的研究，以及将生理学纳入健康和疾病进展的纵向流行病学研究。学员们的工作效率很高，他们的研究获得了广泛认可，并在以老龄化为重点的有吸引力的职位上开启了自己的职业生涯。毕业生将成为多学科研究团队的有效领导者，解决与美国人口老龄化相关的健康问题。