SkyScan 1172 High-resolution desk-top micro-CT system

SkyScan 1172 高分辨率台式显微 CT 系统

• 批准号: 7213201
• 负责人: JAMES C WILLIAMS
• 金额: $ 29.66万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-15 至 2008-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7213201
• 关键词: Antineoplastic Agents; Architecture; Area; Arts; Biological; Biopsy; Blood Vessels; Bone Development; Bone Diseases; Calcium; Calculi; Chronic Kidney Failure; Communities; Computer software; Dental caries; Deposition; Disease; Early Diagnosis; Felis catus; Funding; Future; Genetic; Hour; Image; Imagery; Kidney; Kidney Calculi; Laboratories; Limb structure; Lithotripsy; Maps; Myocardial Infarction; Operative Surgical Procedures; Organ; Osteolytic; Osteoporosis; Patients; Peripheral Vascular Diseases; Research; Resolution; Sampling; Scanning; Services; Shock; Slice; Specimen; Staging; Structure; System; Technology; Vascular calcification; Work; Wound Healing; X-Ray Computed Tomography; base; bone; reconstruction; scaffold; size; soft tissue; vascular bed

DESCRIPTION (provided by applicant): This proposal is for the purchase of a SkyScan 1172 micro computed tomography (CT) system, which will serve ten NIH-funded research groups. Our present micro CT system has been working at maximum capacity for five years, but its quality of image resolution is not adequate for applications to soft tissue or to any structures smaller than about 25 ¿m. The demand for micro CT on our campus continues to grow, and the proposed system will allow excellent resolution of fine structure even in low contrast samples, so that new applications for micro CT can be accommodated or developed. The SkyScan 1172 can image specimens with very high resolution-less than 1 ¿m voxel size and low-contrast resolution of 5 ¿m. A typical scan takes only about one hour, and the system comes with a reconstruction workstation of clustered PC's and special software to allow rapid calculation of image slices, so that a user can reconstruct a scan while the next specimen is scanning. This will provide the high throughput required to service the needs of our research community for micro CT. Applications for the proposed facility include: 1) Elucidation of the fine structure of kidney stones, for studies of the mechanisms of stone breakage by shock wave lithotripsy and study of stone formation. 2) Visualization of fine structure of kidney biopsies taken from stone patients during surgery, showing the earliest stages of the formation of kidney stones. 3) Detection of the earliest stages of dental caries. 4) Mapping and quantitation of vascular calcification in chronic renal disease. 5) Quantitation and imaging of vascular beds in limbs and organs injected with contrast fill, to study peripheral vascular disease and myocardial infarction. 6) Imaging and quantitation of bone structure in studies of osteoporosis, of the genetic basis of bone architecture, of osteolytic cancer, drug effects on bone, development of microcracks, wound healing in bone, and of bone regrowth in artificial scaffolds. The acquisition of the SkyScan 1172 is essential for continued progress on these and future projects requiring this state-of-the-art technology. Relevance. This proposal is for purchase of a new micro CT ("cat" scanner) system, which will be used to study biological specimens from several laboratories. This technology will make possible new discoveries in the areas of bone disease (such as osteoporosis), blood vessel disease (including the deposition of calcium in vessels in chronic kidney disease), tooth decay, and kidney stone disease.

描述（由应用程序提供）：该提案用于购买Skyscan 1172微型计算机断层扫描（CT）系统，该系统将为十个由NIH资助的研究小组提供服务。我们目前的微型CT系统已经以最大的能力运行了五年，但是其图像分辨率的质量不足以适用于软组织或小于25€m的任何结构。我们校园中对微CT的需求继续增长，即使在低对比度样本中，提出的系统也可以很好地解决精细结构，以便可以容纳或开发微型CT的新应用。 Skyscan 1172可以成像具有非常高的分辨率的标本，该标本与1 voxel尺寸和低对比度分辨率为5€m。典型的扫描仅需大约一个小时，并且该系统带有群集PC和特殊软件的重建工作站，以允许快速计算图像切片，以便用户可以在下一个样品进行扫描时重建扫描。这将为满足我们的研究社区对Micro CT的需求提供高吞吐量。提议的设施的应用包括：1）阐明肾结石的精细结构，用于研究通过冲击波岩石碎屑和石材形成研究石材破裂的机理。 2）在手术期间从石头患者中取出的肾脏活检的精细结构的可视化，显示了肾结石形成的最早阶段。 3）检测龋齿的最早阶段。 4）慢性肾脏疾病中血管钙化的映射和定量。 5）对对比度填充的四肢和器官中血管床的定量和成像，研究周围血管疾病和心肌梗塞。 6）骨结构的成像和定量骨质疏松症，骨骼结构的遗传基础，骨化癌的遗传基础，药物对骨骼的影响，微裂纹的发育，骨骼的伤口愈合以及人工支架中的骨改革。对Skyscan 1172的收购对于需要这种最先进技术的这些项目和未来项目的持续进展至关重要。 关联。该建议是用于购买新的Micro CT（“ CAT”扫描仪）系统，该系统将用于研究来自几个实验室的生物标本。这项技术将使骨骼疾病（例如骨质疏松症），血管疾病（包括慢性肾脏病中血管中的沉积），牙齿衰减和肾结石病的新发现可能成为可能的新发现。

项目成果

Cortical and trabecular bone benefits of mechanical loading are maintained long term in mice independent of ovariectomy.

• DOI: 10.1002/jbmr.2143
• 发表时间: 2014
• 期刊: JOURNAL OF BONE AND MINERAL RESEARCH
• 影响因子: 6.2
• 作者: Warden, Stuart J.;Galley, Matthew R.;Hurd, Andrea L.;Richard, Jeffrey S.;George, Lydia A.;Guildenbecher, Elizabeth A.;Barker, Rick G.;Fuchs, Robyn K.
• 通讯作者: Fuchs, Robyn K.

Re: Grases et al.: Origin and types of calcium oxalate monohydrate papillary renal calculi (Urology 2010;76:1339-1345).

回复：Grases 等人：一水草酸钙乳头状肾结石的起源和类型（Urology 2010；76：1339-1345）。

• DOI: 10.1016/j.urology.2011.05.016
• 发表时间: 2011
• 期刊: Urology
• 影响因子: 2.1
• 作者: WilliamsJr,JamesC;Evan,AndrewP;Lingeman,JamesE;Evan,AndrewP
• 通讯作者: Evan,AndrewP

Reduced gravitational loading does not account for the skeletal effect of botulinum toxin-induced muscle inhibition suggesting a direct effect of muscle on bone.

重力负荷的减少并不能解释肉毒杆菌毒素诱导的肌肉抑制对骨骼的影响，表明肌肉对骨骼的直接影响。

• DOI: 10.1016/j.bone.2013.01.043
• 发表时间: 2013
• 期刊: Bone
• 影响因子: 4.1
• 作者: Warden,StuartJ;Galley,MatthewR;Richard,JeffreyS;George,LydiaA;Dirks,RachelC;Guildenbecher,ElizabethA;Judd,AshleyM;Robling,AlexanderG;Fuchs,RobynK
• 通讯作者: Fuchs,RobynK

Compromised osseous healing of dental extraction sites in zoledronic acid-treated dogs.

• DOI: 10.1007/s00198-010-1268-4
• 发表时间: 2011-02
• 期刊: OSTEOPOROSIS INTERNATIONAL
• 影响因子: 4
• 作者: Allen, M. R.;Kubek, D. J.;Burr, D. B.;Ruggiero, S. L.;Chu, T. -M. G.
• 通讯作者: Chu, T. -M. G.

A comparison of calcium to zoledronic acid for improvement of cortical bone in an animal model of CKD.

• DOI: 10.1002/jbmr.2089
• 发表时间: 2014-04
• 期刊: JOURNAL OF BONE AND MINERAL RESEARCH
• 影响因子: 6.2
• 作者: Moe, Sharon M.;Chen, Neal X.;Newman, Christopher L.;Gattone, Vincent H., II;Organ, Jason M.;Chen, Xianming;Allen, Matthew R.
• 通讯作者: Allen, Matthew R.