Evaluation of New Imaging Methodologies at 7T

7T 新成像方法的评估

• 批准号: 7125717
• 负责人: Ewart Mark Haacke
• 金额: $ 199万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125717
• 关键词: Adult; Age; Anatomy; Animal Experimentation; Animal Model; Animals; Area; Arts; Biomedical Research; Blood Vessels; Brain; Clinical; Communities; Country; Development; Diabetes Mellitus; Evaluation; Eye; Funding; Funding Applicant; Human; Image; Invasive; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Mental disorders; Methodology; Mus; Newborn Infant; Noise; Oxygen; Range; Rattus; Research; Research Project Grants; Resolution; Retinal Neoplasms; Signal Transduction; Spectrum Analysis; System; Technology; Time; Tissues; Translational Research; Translations; Trauma; United States National Institutes of Health; Universities; Vascular Diseases; angiogenesis; human study; medical schools; systems research; tumor

DESCRIPTION (provided by applicant): Funds for the acquisition of a 30 cm bore, actively shielded 7.0 T imaging (MRI) and spectroscopy (MRS) Bruker/Siemens animal research system are requested. There is a strong need for a state-of-the-art high field animal system at Wayne State University School of Medicine. There are two existing Bruker animal research systems, a 4.7T 30cm bore and an 11JT small bore system. The first unit does not provide the necessary signal-to-noise while the second is not routinely configured to perform imaging. The need for higher signal-to-noise ratio and resolution is critical for the numerous research projects underway at Wayne State University (WSU). The 4.7T animal system is part of our user's facilty and its usage is high. In addition, we have a whole body 4T Bruker/Siemens system and with the addition of 7T human systems around the country having a system that will allow translation of our research directly to human studies even though outside our own facility is a major advantage. This will make our research more valuable to the imaging research community in general. A group of seven major users will require the majority of machine time on the 7.0 T system but there are at least seven other projects already underway seeking NIH funding. These projects focus on high resolution imaging of the eye, oxygen saturation imaging, tumor imaging, spectroscopy, angiogenesis, vascular imaging and trauma. These projects relate to important areas such as diabetes, vascular disease and psychiatric disorders. Many of the approaches developed and applied on this animal system are expected to have important clinical impact. All of these projects will substantially benefit from the proposed acquisition.

描述（由申请人提供）：要求获得30厘米孔，主动屏蔽7.0 t成像（MRI）和光谱（MRS）Bruker/Siemens动物研究系统的资金。韦恩州立大学医学院的最先进的高野外动物系统非常需要。有两个现有的布鲁克动物研究系统，一个4.7t 30厘米孔和一个11JT小孔系统。第一个单元不提供必要的信号到噪声，而第二个单元则不常规地配置为执行成像。对于韦恩州立大学（WSU）进行的众多研究项目至关重要，需要更高的信噪比和分辨率。 4.7吨动物系统是我们用户智能的一部分，其使用量很高。此外，我们拥有一个全身4T Bruker/Siemens系统，并且在全国范围内增加了7T人类系统，即使我们自己的设施以外的设施是一个主要优势，该系统即使我们的研究将直接转化为人类研究。这将使我们的研究对整个成像研究社区更有价值。一组七个主要用户将需要在7.0 T系统上大部分机器时间，但是至少还有七个其他项目正在寻求NIH资金。这些项目着重于眼睛的高分辨率成像，氧饱和成像，肿瘤成像，光谱，血管生成，血管成像和创伤。这些项目与重要领域有关，例如糖尿病，血管疾病和精神疾病。预计在该动物系统上开发和应用的许多方法都具有重要的临床影响。所有这些项目将在拟议的收购中受益匪浅。