Cold Spring Harbor Laboratory Conference on The Ubiquitin Family

冷泉港实验室泛素家族会议

• 批准号: 7220831
• 负责人: TERRI I. GRODZICKER
• 金额: $ 0.5万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-11 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7220831
• 关键词: Cold; Spring; Harbor; Laboratory; Conference

DESCRIPTION (provided by applicant): Modification of target proteins by ubiquitin and ubiquitin-like polypeptides has emerged as a major mechanism for regulating many cellular processes ranging from metabolic control to cell cycle progression. In turn, these intracellular functions translate into key roles for ubiquitin modification systems in the control of complex regulatory programs at the organismal level including differentiation, development, circadian rhythms, and storage of memories. Although our knowledge of the biological functions of ubiquitin modification systems has exploded over the past decade, our understanding of how these systems operate at a biochemical level remains relatively modest. However, the past few years have witnessed a tremendous surge in the availability of three dimensional structures of components of these modification systems, which is beginning to foster a deeper understanding of how these proteins work. In addition, novel proteomic and functional genomic tools are revealing new functions for components of ubiquitin modification systems, and shedding light on how modification enzymes and substrates are linked together into networks. The objective of the third Cold Spring Harbor meeting on Ubiquitin is to bring together investigators who study the biochemical and structural properties of ubiquitin modification systems with investigators who focus on their biological functions and systems architecture. Given the rapid developments over the past two years, this meeting presents a exciting opportunity for participants to learn about recent developments that will be relevant to their own research. The program will include 8 sessions covering the components of ubiquitin modification systems and the cellular and organismal processes that they control. The sessions will be led by two outstanding and well-known investigators in these areas. With the exception of overview talks presented by the session chairs, all of the talks and posters to be presented will be selected from submitted abstracts, and most of the talks will be given by students, postdoctoral fellows and other younger investigators. It is expected that more than 275 scientists will attend. Of these, over half are likely to be graduate students and postdoctoral fellows. The subsequent meetings (2009 and 2011) will follow a similar format which will include topics that are highly relevant to the current research at the time of the meeting.

描述（由申请人提供）：通过泛素和泛素样多肽对靶蛋白的修饰已成为调节从代谢控制到细胞周期进程的许多细胞过程的主要机制。 反过来，这些细胞内功能转化为泛素修饰系统的关键作用，在控制生物层的复杂调节程序中，包括分化，发育，昼夜节律和记忆的存储。 尽管在过去的十年中，我们对泛素修饰系统生物学功能的了解已经爆炸，但我们对这些系统如何在生化层面运行的理解仍然相对谦虚。 但是，过去几年见证了这些修饰系统组件组件的三维结构的可用性激增，这些结构开始更深入地了解这些蛋白质的工作原理。 此外，新颖的蛋白质组学和功能基因组工具正在揭示泛素修饰系统组件的新功能，并阐明了修饰酶和底物如何将其链接到网络中的启示。 第三次冷泉港会议上关于泛素的目的是将研究人员汇集到研究泛素修饰系统的生化和结构特性的研究者，研究人员专注于其生物学功能和系统体系结构。 鉴于过去两年的迅速发展，这次会议为参与者提供了一个令人兴奋的机会，可以了解与他们自己的研究相关的最新发展。 该程序将包括8个会话，涵盖泛素修饰系统的组成部分以及它们控制的细胞和有机过程。 这些会议将由这些领域的两名杰出且知名的调查员领导。 除了会议主席发表的概述演讲外，所有要提交的会谈和海报都将从提交的摘要中选择，并且大多数会谈将由学生，博士后研究员和其他年轻的调查员进行。 预计将有275多名科学家参加。 其中，一半以上可能是研究生和博士后研究员。 随后的会议（2009年和2011年）将遵循类似的格式，该格式将包括与当前会议时目前的研究高度相关的主题。