CSHL Conference on Telomeres and Telomerase

CSHL端粒和端粒酶会议

基本信息

批准号：
7225148
负责人：
TERRI I. GRODZICKER
金额：
$ 2万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-15 至 2008-05-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Cold Spring Harbor Laboratory Conference on Telomeres and Telomerase May 2-6, 2007 Telomeres are specialized protein-DNA complexes that protect the ends of eukaryotic chromosomes. In most eukaryotes, telomeres contain short DNA repeats that are maintained by the telomerase reverse transcriptase. Since telomerase counteracts the terminal sequence loss that accompanies replication of linear DNA, the enzyme is required for long term cellular proliferation. The field of telomere biology has grown rapidly since it was recognized that telomere dynamics and telomerase activation play a pivotal role in human cancer and in cellular senescence. As a result, the telomere field is now a highly diverse and dynamic area, representing a wide variety of research interests (cancer, aging, cell cycle, meiosis, recombination, replication, etc.) and a large number of different model organisms (mammals, fungi, protozoa, plants). The previous four Cold Spring Harbor Laboratory meetings on Telomeres and Telomerase, were crucial in bringing together this diverse group of researchers and resulted in vigorous discussion and synergistic interactions stimulated by the presentation of a very large body of unpublished data. Since the CSH Telomere and Telomerase meeting represents the only opportunity for scientists in this rapidly growing field to interact as a whole, this meeting is of the utmost importance for the future of the field. Furthermore, the format of CSH meetings, where all talks are chosen from submitted abstracts, maximizes the opportunity for new researchers and young investigators to present their most recent unpublished work. The prior meetings had a uniformly high attendance rate from an international group of researchers. The platform presentations and posters at the past meeting presented the major discoveries in the field well before publication. We anticipate that the 2007 meeting will be equally well attended. The Cold Spring Harbor Laboratory meetings on Telomeres and Telomerase, are crucial in bringing together this diverse group of researchers. The 2007 meeting will result in vigorous discussion and synergistic interactions stimulated by the presentation of a large body of unpublished data. Telomeres are specialized protein-DNA complexes that protect the ends of eukaryotic chromosomes. The field of telomere biology has grown rapidly since it was recognized that telomere dynamics and telomerase activation play a pivotal role in human cancer and in cellular senescence. As a result, the telomere field is now a highly diverse and dynamic area, representing a wide variety of research interests (cancer, aging, cell cycle, meiosis, recombination, replication, etc.) and a large number of different model organisms (mammals, fungi, protozoa, plants).

描述（由申请人提供）：端粒和端粒酶的冷泉港实验室会议，2007年5月2-6日，端粒是专门的蛋白质-DNA复合物，可保护真核染色体的末端。在大多数真核生物中，端粒包含短的DNA重复序列，这些重复酶由端粒酶逆转录酶维持。由于端粒酶抵消了线性DNA复制的末端序列损失，因此长期细胞增殖需要酶。自从人们认识到端粒动力学和端粒酶激活在人类癌症和细胞衰老中起关键作用以来，端粒生物学领域就迅速发展。结果，端粒场现在是一个高度多样化的动态区域，代表了各种各样的研究兴趣（癌症，衰老，细胞周期，减数分裂，重组，复制等），以及大量不同的模型生物（哺乳动物，真菌，原生动物，原生动物，植物）。前四次关于端粒和端粒酶的冷春港实验室会议对于将这一多样化的研究人员汇集在一起至关重要，并通过出现了大量未公开的数据而激发了激烈的讨论和协同互动。由于CSH端粒和端粒酶会议代表了这个迅速增长的领域中整个互动的科学家的唯一机会，因此这次会议对于该领域的未来至关重要。此外，CSH会议的格式是从提交的摘要中选择的所有谈判，最大程度地吸引了新研究人员和年轻研究人员提供最新未发表的作品的机会。先前的会议来自国际研究人员的出勤率均匀出勤率。在过去的会议上，平台演讲和海报在出版前介绍了该领域的主要发现。我们预计2007年的会议将同样受到良好参加。冷泉港实验室的端粒和端粒酶会议对于将这一多样化的研究人员汇集在一起至关重要。 2007年的会议将导致大量未发表的数据的介绍所激发的讨论和协同互动。端粒是保护真核染色体末端的专门蛋白-DNA复合物。自从人们认识到端粒动力学和端粒酶激活在人类癌症和细胞衰老中起关键作用以来，端粒生物学领域就迅速发展。结果，端粒场现在是一个高度多样化的动态区域，代表了各种各样的研究兴趣（癌症，衰老，细胞周期，减数分裂，重组，复制等），以及大量不同的模型生物（哺乳动物，真菌，原生动物，原生动物，植物）。