Cholesterol metabolism-dependent control of tumour-associated macrophage function

肿瘤相关巨噬细胞功能的胆固醇代谢依赖性控制

• 批准号: 2889838
• 金额: --
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2889838
• 关键词: Cholesterol; metabolism; dependent; control; tumour

Ovarian cancer has one of the poorest survival rates and is difficult to diagnose and treat. Immune cells called macrophages can fight cancer cells, but instead they appear to help ovarian cancer cells spread around the body. This project aims to determine one of the mechanisms by which macrophages promote tumour growth, and explore possible treatments to block this. Our lab has developed recent new insights into how cholesterol metabolism of macrophages might control their inflammatory function. We think this is relevant for ovarian cancer because patients who have high expression of enzymes involved in cholesterol metabolism are more likely to die than patients with low expression. The student will use cutting-edge cancer models (3D organoids, mouse transplant) to test how cholesterol metabolism of macrophages affects the growth and spread of ovarian cancer. The student will be co-supervised by basic discovery scientists with expertise in macrophage biology and cancer immunology (Drummond, Caamano), as well as clinical oncologist (Leung) to develop a clinically-relevant project that uses a bench-to-bedside approach to make new discoveries in the pathogenesis of a deadly cancer.

卵巢癌是存活率最差的癌症之一，并且难以诊断和治疗。称为巨噬细胞的免疫细胞可以对抗癌细胞，但它们似乎有助于卵巢癌细胞在全身扩散。该项目旨在确定巨噬细胞促进肿瘤生长的机制之一，并探索可能的治疗方法来阻止这种机制。我们的实验室最近对巨噬细胞的胆固醇代谢如何控制其炎症功能有了新的见解。我们认为这与卵巢癌相关，因为参与胆固醇代谢的酶高表达的患者比低表达的患者更有可能死亡。学生将使用尖端癌症模型（3D 类器官、小鼠移植）来测试巨噬细胞的胆固醇代谢如何影响卵巢癌的生长和扩散。该学生将由具有巨噬细胞生物学和癌症免疫学专业知识的基础发现科学家（Drummond、Caamano）以及临床肿瘤学家（Leung）共同监督，开发一个临床相关项目，使用从实验室到临床的方法来在致命癌症的发病机制方面取得新发现。