FASEB Summer Conference on Helicase and NTP-Driven Nucleic Acid Motors: Structure

FASEB 夏季会议：解旋酶和 NTP 驱动的核酸马达：结构

• 批准号: 7275465
• 负责人: Timothy M Lohman
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-15 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7275465
• 关键词: Advertising; Aging; Air Conditioning; American; Architecture; Area; Biogenesis; Biological; Biology; Biomedical Research; Bloom Syndrome; California; Cell Wall; Cells; Cockayne Syndrome; Communities; Complex; Condition; DNA; DNA biosynthesis; Data; Defect; Disease; Enzymes; Equipment; Eye; Fees; Female; Funding; Future; Gene Expression; Genes; Genetic; Genetic Conjugation; Genetic Transcription; Genomic Instability; Goals; Growth; Guidelines; Hereditary Disease; Housing; Human; Human Genetics; Hydrolysis; Incidence; Inherited; Journals; Left; Malignant Neoplasms; Medical; Membrane; Molecular Motors; Motor; Movement; Mutation; Nature; Newsletter; Nucleic Acids; Oral; Participant; Process; Protein Binding; Proteins; Publications; Publishing; RNA; RNA Degradation; RNA Editing; RNA Splicing; RNA Transport; Recruitment Activity; Regulation; Research; Research Personnel; Resort; Ribosomes; Role; Science; Scientific Societies; Scientist; Site; Societies; Structural Biologist; Structure; Students; Switzerland; Translations; Underrepresented Minority; Universities; Viral Packaging; Washington; Werner Syndrome; Woman; Xerodermas; base; day; enzyme activity; helicase; human disease; insight; interest; medical schools; nucleic acid metabolism; posters; programs; recombinational repair; response; symposium; translocase; tumorigenesis; virology

DESCRIPTION (provided by applicant): This application is for partial funding of the 2007 FASEB Summer Conference on "Helicases and NTP-Driven Nucleic Acid Motors: Structure, Function, Mechanism and Roles in Human Diseases." The conference will be held from June 23 to June 28, 2007 at the Hyatt Grand Champions Resort & Spa in Indian Wells, CA under the auspices of the Federation of American Societies of Experimental Biology (FASEB). There will be nine major scientific sessions; each session will include an average of four to five speakers, each presenting a 25-minute oral talk. There also will be two poster sessions, both of which will last two days. Helicases are molecular motor proteins that use the energy of NTP hydrolysis to translocate unidirectionally along nucleic acids, separating the complementary strands of the nucleic acid duplex. Helicase/translocase proteins also can destabilize the secondary structure of RNA, remove proteins bound to nucleic acid segments, and facilitate the movement of DNA and RNA chains through various pores, cell walls, and membranes. As a consequence of such activities, these enzymes serve as integral components of the cellular machineries responsible for all nucleic acid transactions, including DNA replication, repair, recombination, transcription, ribosome biogenesis, translation, RNA splicing, RNA editing, RNA transport, RNA degradation, bacterial conjugation, and viral packaging/unpackaging. The central nature of helicases and translocases to biomedical research has been underscored by the recent discovery that several inherited human diseases (e.g. Bloom syndrome, Werner syndrome, Cockayne syndrome and Xeroderma pigmentosum) are caused by defects in genes encoding specific helicases. Helicase defects are also associated with genomic instability and an increased cancer incidence. Despite the importance of this group of proteins, however, there is still much that we do not understand about helicase structure and mechanism; we know even less about the biological role of helicases in complex processes like oncogenesis and aging. The helicase/translocase field is progressing at an extremely rapid pace, with new insights into architecture, function, and the role of helicases in human disease emerging on a weekly basis. This is the third FASEB meeting on this subject (the meeting in 2005 was organized through EMBO) since discovery of the first helicase about 30 years ago. Demand has increased with each session, further highlighting the general interest of this research area to the scientific community at large. This proposal will highlight the background and goals of the 2007 FASEB meeting, with an eye to bring together structural biologists, enzymologists, biochemists, geneticists, and clinicians to share ideas and new information on these enzymes, crosstalk that is key to inform and facilitate research breakthroughs in the future.

描述（由申请人提供）：此申请是为2007年FaseB夏季会议的部分资助“解旋酶和NTP驱动的核酸电动机：结构，功能，机制和在人类疾病中的作用”。该会议将于2007年6月23日至6月28日在美国加利福尼亚州印度韦尔斯的凯悦大锦标赛度假胜地和水疗中心举行，由美国实验生物学联合会（FASEB）举行。将有九次主要的科学会议；每个会话平均包括四到五位演讲者，每个演讲者都会进行25分钟的口头演讲。还将有两个海报会议，这两个都将持续两天。解旋酶是分子运动蛋白，它们利用NTP水解的能量沿核酸单向转移，将核酸双链体的互补链分开。解旋酶/易位酶蛋白还可以破坏RNA的二级结构，去除与核酸片段结合的蛋白质，并促进DNA和RNA链通过各种孔，细胞壁和膜的运动。由于这些活性的结果，这些酶是负责所有核酸交易的细胞机制的组成部分，包括DNA复制，修复，重组，转录，核糖体生物发生，翻译，RNA拼接，RNA剪接，RNA编辑，RNA传输，RNA转运，RNA脱离，RNA Degractation，细菌Conjugatial conjugation and viral andal/divack nigatigage/divack nigatigage/divacking nigatigage/divack gientage/difack nigatigage。最近发现的一些遗传性人类疾病（例如Bloom综合征，Werner综合征，Cockayne综合征和Xeroderma choroderma cockmentosum）强调了解旋酶和易生酶对生物医学研究的核心性质。解旋酶缺陷也与基因组不稳定性和癌症发病率增加有关。尽管这组蛋白质很重要，但是对于解旋酶结构和机制来说，仍然有很多我们不了解。我们对解旋酶在肿瘤发生和衰老等复杂过程中的生物学作用的了解甚至更少。解旋酶/易位酶场的发展速度极快，对建筑，功能以及解旋酶在每周出现的人类疾病中的作用有了新的见解。这是自大约30年前发现第一个解旋酶以来的第三次FaseB会议（2005年的会议是通过EMBO组织的）。每次会议的需求都在增加，进一步强调了该研究领域对整个科学界的一般利益。该提案将重点介绍2007年FASEB会议的背景和目标，以召集结构生物学家，酶学家，生物化学家，遗传学家和临床医生分享有关这些酶的想法和新信息，这些酶，这是为未来的研究和促进研究突破的关键。