The Biology of Chromosome 21 Genes: towards Gene-Phenotype Correlations in Down

21 号染色体基因的生物学:唐氏基因与表型相关性

基本信息

  • 批准号:
    7533819
  • 负责人:
  • 金额:
    $ 1.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-07-01 至 2008-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): To create new research directions and opportunities for new collaborations in Down syndrome research, there is a need to bring together two groups of investigators: (1) those specifically studying human chromosome 21 and Down syndrome and its mouse models, and (2) those studying the cell/molecular biology of specific genes that map to chromosome 21 or specific pathways whose components map to chromosome 21, and those developing/using novel methodologies that might be applicable to Down syndrome research. The first group includes experts on chromosome 21 who have been involved in the mapping, sequencing, and annotation of chromosome 21 and orthologous mouse genomic regions, the identification and expression analysis of chromosome 21 and orthologous mouse genes, the creation and analysis of mouse models of Down syndrome, both segmental trisomies and transgenics, and the definition of the human Down syndrome phenotype. Investigators in the second group are not involved in Down syndrome research and may not even be aware that their work can impact Down syndrome research. They are studying individual genes or family members such as transcription factors, protein modifiers, or cell surface receptors that map to chromosome 21, or pathways/processes such as neurogenesis, cell adhesion, or signal transduction, each of which has several component or modulating genes mapping to chromosome 21. Or they are using large scale approaches to assay protein expression or mathematical modeling for pathway analysis. This application requests funding to cover venue and travel expenses for a workshop to bring together approximately 30 established chromosome 21 Down syndrome investigators with approximately 20 non-Down syndrome but chromosome 21 gene/pathway experts to discuss the biology of chromosome 21-encoded genes and the implications for their overexpression in the Down syndrome phenotype. The meeting will be held for three days in Washington, DC within a time frame of five months after the availability of funding. It is anticipated that this workshop will generate new, testable theories for gene-phenotype correlations in Down syndrome, foster new collaborations, and introduce new researchers with novel expertise to the Down syndrome research field.

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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KATHELEEN GARDINER其他文献

KATHELEEN GARDINER的其他文献

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{{ truncateString('KATHELEEN GARDINER', 18)}}的其他基金

NIH Support of Conferences and Scientific Meetings
NIH 对会议和科学会议的支持
  • 批准号:
    8459141
  • 财政年份:
    2013
  • 资助金额:
    $ 1.5万
  • 项目类别:
Systems Biology for Studies of Cognition in Down Syndrome
唐氏综合症认知研究的系统生物学
  • 批准号:
    8066269
  • 财政年份:
    2010
  • 资助金额:
    $ 1.5万
  • 项目类别:
Systems Biology for Studies of Cognition in Down Syndrome
唐氏综合症认知研究的系统生物学
  • 批准号:
    7589834
  • 财政年份:
    2008
  • 资助金额:
    $ 1.5万
  • 项目类别:
Systems Biology for Studies of Cognition in Down Syndrome
唐氏综合症认知研究的系统生物学
  • 批准号:
    8239531
  • 财政年份:
    2008
  • 资助金额:
    $ 1.5万
  • 项目类别:
Systems Biology for Studies of Cognition in Down Syndrome
唐氏综合症认知研究的系统生物学
  • 批准号:
    7462512
  • 财政年份:
    2008
  • 资助金额:
    $ 1.5万
  • 项目类别:
Systems Biology for Studies of Cognition in Down Syndrome
唐氏综合症认知研究的系统生物学
  • 批准号:
    8059586
  • 财政年份:
    2008
  • 资助金额:
    $ 1.5万
  • 项目类别:
Systems Biology for Studies of Cognition in Down Syndrome
唐氏综合症认知研究的系统生物学
  • 批准号:
    7797677
  • 财政年份:
    2008
  • 资助金额:
    $ 1.5万
  • 项目类别:
The Biology of Chromosome 21 Genes: towards Gene-Phenotype Correlations in Down
21 号染色体基因的生物学:唐氏基因与表型相关性
  • 批准号:
    7277875
  • 财政年份:
    2007
  • 资助金额:
    $ 1.5万
  • 项目类别:
Disregulation of Calcineurin in Mouse Models of Down Syn
唐氏综合症小鼠模型中钙调神经磷酸酶的失调
  • 批准号:
    6900506
  • 财政年份:
    2005
  • 资助金额:
    $ 1.5万
  • 项目类别:
Disregulation of Calcineurin in Mouse Models of Down Syn
唐氏综合症小鼠模型中钙调神经磷酸酶的失调
  • 批准号:
    7035930
  • 财政年份:
    2005
  • 资助金额:
    $ 1.5万
  • 项目类别:

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