RR-03-011, Extramural Research Facilities Construction *

RR-03-011，校外研究设施建设*

• 批准号: 6863822
• 负责人: DALLAS Melvin HYDE
• 金额: $ 380万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6863822
• 关键词: RR; 03; 011; Extramural; Research

DESCRIPTION (provided by applicant): The California National Primate Research Center (CNPRC) is proposing to construct a new building, the Virology and Immunology Laboratory (VIL) that will house the Virology and Immunology (V&I) Unit on the CNPRC campus. The specific aims of this proposal are to: (1) address significant deficiencies of research space, forcing the CNPRC to situate Staff Scientists (mainly from the Respiratory Disease (RD) Unit) in six widely separated spaces on campus, (2) co-locate V&I researchers currently widely dispersed at the CNPRC and Center for Comparative Medicine (CCM, located on CNPRC property), (3) provide appropriate containment (e.g., level 3) facilities and other current technologies that enable researchers to investigate diseases that they are currently unable to study and (4) provide new space for recruitment of Staff Scientists in cell and gene based therapies. These specific aims will be accomplished by providing high quality research laboratory space, research support space and office space for faculty, staff and graduate students in the (1) V&I Unit, whose research is focused on non-human primate models of human infectious diseases, including AIDS and (2) RD Unit, whose research is focused on non-human primate models of human respiratory diseases, including asthma. Construction of the VIL will also serve the long-term objective of expanding and integrating the research effort in the V&I Unit on the CDC/NIAID categorical pathogens. In fact, we propose to build the BSL-3 laboratories as part of the new building. This lab space is needed to make use of the BSL-3 animal quarters that exist at the CNPRC. V&I Staff Scientists work with viruses that must be handled at bio-safety level-2 (BSL-2) containment. The investigators in the Unit have developed appropriate procedures for the safe handling of these organisms and the institutional committees have approved the use of the agents in specific V&I Unit laboratories. However the physical configuration of the aging lab space of the Unit is less than optimal and requires strict adherence to the procedural approaches for containment of these pathogens. Hence, working conditions are not safe and Staff Scientists of the V&I Unit are only able to work in their current space through cumbersome procedures that slow progress to a crawl. The new containment labs in the VIL will be used by current Staff Scientists, new faculty recruits, and with scientists in other UCD departments or other institutions that share this investigational focus. This proposed metal frame building will be built on a new foundation with overall dimensions of 9,873 gross-square feet (GSF). The building will include 5,992 assignable square feet (ASF) of laboratory research space, 178 ASF of research support space and 1,200 ASF of office space. The research laboratory space will include wet laboratories and ten dry lab/support spaces. There will be eight offices of 120 ASF each and one office/conference space of 240 ASF. The new space will accommodate the existing research programs of V&I Staff Scientists that are focused on non-human primate models of viral diseases of humans and provide space for expansion of these activities. Construction of the proposed facility will permit consolidation of existing research activities with human pathogens in modern BSL-2 and BSL-3 containment.

描述（由申请人提供）： 加州国家灵长类动物研究中心 (CNPRC) 提议建造一座新大楼，即病毒学和免疫学实验室 (VIL)，该实验室将在 CNPRC 园区内容纳病毒学和免疫学 (V&I) 部门。该提案的具体目标是：(1) 解决研究空间的重大缺陷，迫使 CNPRC 将科研人员（主要来自呼吸疾病 (RD) 部门）安置在校园内六个相距较远的空间中，(2)找到目前广泛分散在 CNPRC 和比较医学中心（CCM，位于 CNPRC 财产）的 V&I 研究人员，(3) 提供适当的收容（例如 3 级）设施和其他现有技术，使研究人员能够研究他们目前无法研究的疾病；(4) 为细胞和基因疗法领域的科学家招募提供新的空间。这些具体目标将通过为 (1) V&I 部门的教职员工和研究生提供高质量的研究实验室空间、研究支持空间和办公空间来实现，该部门的研究重点是非人类灵长类动物模型 人类传染病，包括艾滋病和（2）研发单位，其研究重点是人类呼吸道疾病（包括哮喘）的非人类灵长类动物模型。 VIL 的建设还将服务于扩大和整合 V&I 部门关于 CDC/NIAID 分类病原体的研究工作的长期目标。事实上，我们建议将 BSL-3 实验室建设为新大楼的一部分。该实验室空间需要利用 CNPRC 的 BSL-3 动物宿舍。 V&I 科学家们所研究的病毒必须在生物安全 2 级 (BSL-2) 遏制下进行处理。该部门的研究人员已制定了安全处理这些生物体的适当程序，机构委员会已批准在特定的 V&I 部门实验室中使用这些制剂。然而，该单位老化实验室空间的物理配置并不理想，需要严格遵守控制这些病原体的程序方法。 因此，工作条件并不安全，V&I 部门的科学家们只能通过繁琐的程序在当前的空间中工作，这使得进展缓慢如爬行。 VIL 中的新收容实验室将由现有的科学家、新聘的教职员工以及其他 UCD 院系或其他共同研究重点的机构的科学家使用。 这座拟议的金属框架建筑将建在一个新的地基上，总面积为 9,873 平方英尺 (GSF)。该建筑将包括 5,992 平方英尺 (ASF) 的可分配实验室研究空间、178 ASF 的研究支持空间和 1,200 ASF 的办公空间。研究实验室空间将包括湿实验室和十个干实验室/支持空间。将设有 8 个办公室，每个办公室可容纳 120 ASF，还有 1 个办公室/会议空间可容纳 240 ASF。新空间将容纳 V&I 科学家现有的研究项目，这些项目专注于人类病毒性疾病的非人类灵长类动物模型，并为这些活动的扩展提供空间。拟议设施的建设将允许在现代 BSL-2 和 BSL-3 遏制中整合人类病原体的现有研究活动。