Hypersomnia in Major Depressive Disorder: a high-density EEG investigation

重度抑郁症中的嗜睡：高密度脑电图研究

• 批准号: 8586358
• 负责人: David T Plante
• 金额: $ 19.45万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-01 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8586358
• 关键词: Adult; Affect; Area; Award; Biological; Biological Markers; Biometry; Brain; Brain region; Clinical; Clinical Trials Design; Complement; Data; Depressed mood; Development; Disease; Electroencephalogram; Electroencephalography; Evaluation; Event; Failure; Gap Junctions; Goals; Homeostasis; Hour; Hypersomnolence; Individual; Intervention; Investigation; Knowledge; Laboratories; Lead; Learning; Life Cycle Stages; Maintenance; Major Depressive Disorder; Measures; Medicine; Mental Depression; Mental Health; Mental disorders; Mentorship; Modality; Mood Disorders; Moods; Nature; Neurons; Outcome; Parietal; Participant; Pathogenesis; Patients; Physiological; Play; Prevention strategy; Psychiatry; Public Health; Quality of life; Randomized Controlled Trials; Relative (related person); Reporting; Research; Research Personnel; Research Support; Resistance; Resolution; Resources; Risk; Role; Scientist; Sleep; Sleep Disorders; Sleep disturbances; Staging; Techniques; Technology; Testing; Training; Translating; Universities; Wakefulness; Wisconsin; base; density; depressive symptoms; design; disability; disorder prevention; effective therapy; health care delivery; improved; medical schools; multidisciplinary; neurophysiology; novel; novel diagnostics; prospective; public health relevance; research study; restoration; skills; treatment response

DESCRIPTION (provided by applicant): This proposal will support the research and further the applicant's training as a clinician-scientist at the nexus of psychiatry and sleep disorders medicine. Dr. Plante's goals are to examine the neurophysiology of hypersomnolence in depression during sleep and wakefulness, to identify biomarkers for excessive sleepiness, and to ultimately translate these findings into targeted neuromodulatory interventions for individuals with mood disorders. To achieve these aims, a didactic plan focused on the development of: 1) a stronger conceptual grounding of advanced high-density electroencephalogram (hdEEG) applications in mood and sleep disorders research, and 2) more sophisticated methodological skills including biostatistics and clinical trials design, will complement Dr. Plante's background n clinical psychiatry and sleep medicine. Training objectives will be accomplished through targeted coursework and multidisciplinary mentorship in the context of the comprehensive scholarly resources available at the University of Wisconsin School of Medicine and Public Health. The research plan will utilize knowledge and new techniques learned to investigate novel hypotheses regarding the nature of cortical oscillations during sleep and wakefulness in depressed patients with hypersomnia, and thereby alter clinical symptomatology. Adults with unipolar major depressive disorder (MDD) and co-morbid hypersomnolence will be evaluated during sleep and wake using hdEEG, and the nature of their slow wave activity during sleep and theta/alpha activity during wake contrasted with healthy controls and MDD participants without co-morbid hypersomnia. Additionally, hypersomnolent MDD participants will undergo overnight slow wave induction, a novel neuromodulatory therapy, to both examine the role of slow waves in excessive sleepiness and evaluate the efficacy of this somatic treatment in these patients. This prospective examination of the physiologic basis of hypersomnolence in mood disorders is designed to set the stage for the applicant to develop, and ultimately test, novel diagnostic and treatment modalities among hypersomnolent mood disordered patients with the potential to meaningfully improve quality of life and illness-related outcomes. Building on didactic training and data generated by these experiments, Dr. Plante will focus the latter stages of the award on obtaining training in the design of clinical trials and developing a randomized controlled trial of the use of slow wave induction as a novel treatment for mood disorders with co-morbid hypersomnia. At the end of the award period, Dr. Plante will be well-poised to extend his research in several novel directions with clear translational relevance as a fully independent investigator in sleep and psychiatric disorders.

描述（由申请人提供）：该提案将支持研究，并进一步申请人在精神病学和睡眠障碍医学联系的临床医生培训。 Plante博士的目标是检查睡眠和清醒期间抑郁症的抑郁症的神经生理学，以确定过度嗜睡的生物标志物，并最终将这些发现转化为对情绪障碍患者的有针对性的神经调节干预措施。为了实现这些目的，一项侧重于以下发展的教学计划：1）在情绪和睡眠障碍研究中应用高级高密度脑电图（HDEEG）应用的更强概念基础，以及2）更复杂的方法学技能，包括生物统计学和临床​​试验，将补充Plante Plante的背景N临床精神病和睡眠医学。在威斯康星大学医学与公共卫生学院提供的全面学术资源的背景下，将通过有针对性的课程和多学科指导来实现培训目标。该研究计划将利用知识和新技术来研究有关抑郁症患者在睡眠和觉醒期间皮质振荡性质的新假设，从而改变了临床症状。使用HDEEG在睡眠和唤醒期间将评估具有单极重大抑郁症（MDD）和联合性高血压的成年人，以及在唤醒期间睡眠和theta/alpha活性期间的慢波活性的性质与健康对照组对比，而没有共核性高血压。此外，高血压的MDD参与者将经历一种新型的神经调节疗法的过夜慢波诱导，以检查慢波在过度嗜睡中的作用，并评估这种体细胞治疗在这些患者中的功效。这种对情绪障碍性症的生理基础的前瞻性检查旨在为申请人开发，并最终测试过症的诊断和治疗方式，在高度诺尔情绪失调的患者中，具有有意义地改善生活质量和与疾病相关的结果的潜力。在这些实验产生的教学培训和数据的基础上，Plante博士将把奖项的后期阶段集中在获得临床试验设计的培训上，并开发了一项随机对照试验 使用慢波诱导作为对情绪障碍的新型治疗方法。在奖励期结束时，Plante博士将得到充分的序曲，以将他的研究扩展到多个新颖的方向，并以明确的转化相关性，作为睡眠和精神疾病的完全独立的研究者。