Shared Neurobiology of Autism and Related Disorders

自闭症及相关疾病的共享神经生物学

• 批准号: 7276723
• 负责人: Steven Owen Moldin
• 金额: $ 4.8万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7276723
• 关键词: Angelman Syndrome; Arts; Autistic Disorder; Characteristics; Collaborations; Disease; Educational workshop; Etiology; Fostering; Fragile X Syndrome; Functional disorder; Genomics; Goals; Joubert syndrome; Knowledge; Methodology; Molecular; Mus; Neurobiology; Neurodevelopmental Disorder; Neurosciences; Nicotinamide adenine dinucleotide; Pathway interactions; Physiological Processes; Research; Research Personnel; Rett Syndrome; Route; Source; System; Tuberous Sclerosis; Zebrafish; experience; fly; genetic variant; human disease; insight; interdisciplinary approach; multidisciplinary; neurobiological mechanism; novel; novel therapeutics; therapeutic target; tool

DESCRIPTION (provided by applicant): The objective of this workshop is to provide a multidisciplinary discussion of the accumulated evidence, state-of-the-art methodologies and major knowledge gaps in the basic neuroscience of autism and related neurodevelopmental disorders that share common phenotypic characteristics (Fragile X syndrome, Rett syndrome, Angelman syndrome, Tuberous sclerosis and Joubert Syndrome, herein referred to as "neurodevelopmental autism-associated disorders," or NAD). It is extremely timely to assemble scientific leaders across multiple fields of neuroscience and stimulate the conceptual integration of findings across disorders, in order to identify shared neurobiological mechanisms. This is motivated by the conviction that major discoveries in autism will follow as researchers capitalize on independent parallel lines of basic neurobiological research that are beginning to yield tremendous insights into NAD. Discussion will focus on the sophisticated use of multiple experimental systems, e.g., mouse, fly and zebrafish, as critical tools to unravel the etiologies and pathophysiologies of NAD, especially as associated genetic variants are identified. The major goal of carefully considering research findings on NAD is to stimulate basic and translational neuroscience approaches in autism that aim to identify targets for new therapeutics. The workshop will include both new and experienced investigators, and will combine formal presentations and informal discussions to convey the merits and tremendous excitement of molecular, cellular and genomic neuroscience approaches for understanding shared mechanisms common to autism and NAD. Given that advances in understanding fundamental neurodevelopmental and physiological processes frequently have direct relevance to human disease, it is expected that this workshop will provide critical new insights into the pathophysiology and etiology of autism by revealing a rich source of circuits, molecules and pathways for therapeutic targeting. Topics will highlight the value of integrative and multidisciplinary approaches, thereby opening conduits to foster collaborations and networking among young and experienced investigators, while presenting novel and creative routes to investigate the shared neurobiology of autism and NAD.

描述（由申请人提供）：本次研讨会的目的是对自闭症和具有共同表型特征的相关神经发育障碍的基础神经科学中积累的证据、最先进的方法和主要知识差距进行多学科讨论(脆性X综合征、雷特综合征、安格曼综合征、结节性硬化症和乔伯特综合征，本文称为“神经发育自闭症相关疾病”或NAD)。现在非常及时地聚集了神经科学多个领域的科学领导者，并促进了跨疾病研究结果的概念整合，以确定共同的神经生物学机制。这是因为我们坚信，随着研究人员利用基础神经生物学研究的独立平行线，自闭症方面的重大发现将会随之而来，这些研究开始对 NAD 产生巨大的见解。讨论将集中于多种实验系统（例如小鼠、苍蝇和斑马鱼）的复杂使用，作为揭示 NAD 病因和病理生理学的关键工具，特别是在识别出相关遗传变异后。仔细考虑 NAD 研究结果的主要目标是促进自闭症的基础和转化神经科学方法，旨在确定新疗法的靶点。该研讨会将包括新的和经验丰富的研究人员，并将结合正式演讲和非正式讨论，传达分子、细胞和基因组神经科学方法的优点和巨大的兴奋，以了解自闭症和 NAD 的共同机制。鉴于理解基本神经发育和生理过程的进展往往与人类疾病直接相关，预计本次研讨会将通过揭示治疗靶向的丰富的回路、分子和途径，为自闭症的病理生理学和病因学提供重要的新见解。主题将强调综合和多学科方法的价值，从而开辟渠道，促进年轻和经验丰富的研究人员之间的合作和网络，同时提出新颖和创造性的途径来研究自闭症和 NAD 的共同神经生物学。