Research In Pediatric Anxiety Disorders

儿科焦虑症研究

基本信息

批准号：
7184377
负责人：
JOHN S MARCH
金额：
$ 13.67万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-12-15 至 2008-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7184377
关键词：
7,7&apos -dimethoxy-(4,4&apos -bi-1,3-benzodioxole)-5,5&apos -dicarboxylic acid dimethyl ester Abbreviations Academic Medical Centers Academy Accounting Achievement Acute Address Adolescence Adolescent Adolescent Medicine Trials Network Adolescent Psychiatry Advisory Committees Advocate Age-Years Alzheimer&apos s Disease American Americas Anxiety Anxiety Disorders Appendix Applications Grants Aquilegia Area Arts Attention Attention deficit hyperactivity disorder Australia Autistic Disorder Autobiography Automobile Driving Award Back Bacteriophage lambda Baltimore Behavior Therapy Behavioral Behavioral Sciences Biological Psychiatry Biology Biometry Bipolar Disorder Book Chapters Books Brain Budgets Burn injury California Candidate Disease Gene Caring Characteristics Chicago Child Child Abuse Child Psychiatry Child Psychology Child Traumatic Stress Childhood Children&apos s Oncology Group Class Clinical Clinical Investigator Clinical Medicine Clinical Research Clinical Treatment Clinical Trials Code Cods Cognitive Cognitive Therapy Collaborations Combination Medication Combined Modality Therapy Competence Complex Congresses Conscious Consensus Consult Consultations Corpus striatum structure Crossover Design Crows DNA Library Data Data Analyses Data Files Data Set Daughter Decision Analysis Decision Making Depressed mood Depression and Suicide Development Diagnosis Discipline Disease Distant District of Columbia Doctor of Philosophy Drug Industry Economics Educational Curriculum Educational Intervention Educational process of instructing Educational workshop Effectiveness Empiricism Environment Epidemiology Equation Ethics Evaluation Event Evidence Based Medicine Evidence based intervention Exercise Experimental Designs Expert Witnesses Exposure to Face Facility Construction Funding Category Faculty Familiarity Family Family Physicians Family Practice Family history of Fathers Fellowship Floods Fluvoxamine Fortune Foundations Freedom Friends Functional Magnetic Resonance Imaging Funding Future Generations Genetic Gilles de la Tourette syndrome Glossary Glutamate Receptor Goals Grant Hand Haplotypes Head Health Professional Health Services Research Healthcare Home environment Hospitals Hour Human Human Genetics Illinois Image Image Analysis Indian reservation Individual Industry Influentials Institute of Medicine (U.S.)Institutes Instruction Insulin-Dependent Diabetes Mellitus International Intervention Intervention Studies Investigation Journals K-Series Research Career Programs Knowledge Laboratories Language Lead Leadership Learning Left Life Linear Models Link Literature Log-Linear Models Logistic Regressions Logistics Los Angeles Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Manic Manuscripts Master&apos s Degree Measures Mediating Mediator of activation protein Medical Medical Psychology Medication Management Medicine Meditation Mental Depression Mental Health Mental Health Services Mental disorders Mentally Ill Persons Mentored Clinical Oncology Award Mentored Clinical Scientist Award Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methodology Methods Michigan Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Mining Minority Modeling Molecular Molecular Abnormality Molecular Biology Molecular Genetics Montana Moods NIH Program Announcements National Institute of Mental Health National Research Service Awards Nature Nebraska Neuropharmacology Neurosciences Neurosciences Research Nonparametric Statistics Numbers Nursery Schools Obsessive-Compulsive Disorder Outcome Output Paper Parent-Child Relations Parents Paroxetine Patient Care Patients Pattern Pediatric Hospitals Peer Review Pennsylvania Pharmaceutical Preparations Pharmacogenetics Pharmacogenomics Pharmacologic Substance Pharmacological Treatment Pharmacotherapy Phase Philadelphia Physicians Placebos Play Pliability Population Population Research Post-Traumatic Stress Disorders Postdoctoral Fellow Practice Guidelines Preparation Principal Investigator Procedures Process Productivity Professional Organizations Programming Languages Proportional Hazards Models Protons Psyche structure Psychiatrist Psychiatry Psychologist Psychology Psychometrics Psychopathology Psychopharmacology Psychotherapy Psychotic Disorders Public Health Publications Publishing Puerto Rico Purpose Qualifying Randomized Randomized Controlled Trials Reader Reading Receptor Gene Recruitment Activity Regression Analysis Relative (related person)Reporting Research Research Activity Research Design Research Personnel Research Scientist Award Research Support Research Training Residencies Resistance Resources Rewards Role Rotation Running Rural SAS SFN gene Safety San Francisco Schedule Schools Science Scientist Secondary to Secure Series Sertraline Side Site Slide Social Phobia Social Sciences Socialization Societies Source Specific qualifier value Spectrum Analysis Staging Standards of Weights and Measures Statistical Methods Statistical Models Statistical Study Stress Structure Students Subgroup Substance abuse problem Suicide Summary Reports Surrogate Endpoint Surrogate Markers Survival Analysis Symptoms System Techniques Technology Testing Text Thinking Time TimeLine Today Training Training Support Translating Trauma Traumatology Travel Treatment Protocols Treatment outcome Trichotillomania United States Public Health Service Universities Update Veins Violence Visit Wages Washington Water Week Wisconsin Work Writing Youth analog atomoxetine base career case control child depression clinically relevant cognitive neuroscience college comparative computerized data processing concept cooking data management day design direct patient care disorder later incidence prevention distraction early childhood early onset editorial effectiveness trial experience forgetting genetic analysis genetic technology gratitude hatching human SFN protein human subject indexing innovation interest lectures man medical schools member multilevel analysis neuroimaging neuropsychiatry next generation outreach partial response patient oriented patient oriented research pre-doctoral professor programs prospective psychogenetics psychologic psychosocial residence response satisfaction service intervention service utilization skills social separation sound statistics suicidal suicidal adolescent suicidal behavior symposium teacher theories therapy development tool treatment effect treatment trial

项目摘要

DESCRIPTION (provided by applicant): This is a planned competing renewal of the Principal Investigator's K24 Midcareer Investigator Award in Patient-Oriented Research (K24 MH01557-05). The overall scientific objectives of this award are (1) to evaluate the effectiveness and safety of treatments for children and adolescents with major mental illness and (2) to recruit and train junior scientists in the methods and applications of clinical trials in pediatric psychiatry. The initial K24 award, which was focused on anxiety disorders and, more generally, on comparative treatment trials and clinical trials methods, ends in 2003. During this period, Dr. March will have published more than 100 manuscripts; successfully concluded two and launched three (and perhaps as many as five) NIMH-funded clinical trials; developed methodological expertise unusual for a child and adolescent psychiatrist; and successfully mentored more than two dozen junior and mid-career investigators. Thus, Dr. March more than filled the primary aims of the K24 Program Announcement, which emphasizes scientific productivity in patient-oriented research and mentoring activities. This competing continuation application sets out research, didactic, and mentoring agendas designed to make clear the added value of the K24 award. The research agenda includes treatment outcome studies in ADHD, depression, suicide, anxiety disorders, and OCD, with particular attention to the role of the K24 in facilitating secondary analyses. Serving the research agenda, the didactic agenda provides for training in the SAS programming language, neuroimaging, and psychiatric genetics. The mentoring agenda provides for ongoing and new mentoring/consultative activities and for leadership in the area of research workforce issues in child and adolescent psychiatry. By providing stable salary support at 100% effort uninterrupted by non-research patient care and administrative duties, the K24 competing continuation will sustain and promote practical and theoretical contributions to the diagnosis and treatment of mentally ill children and adolescents.

描述（由申请人提供）：这是计划的竞争性续约，该研究人员的K24 K24中级护理研究员授予患者研究奖（K24 MH01557-05）。该奖项的总体科学目标是（1）评估患有重大精神疾病的儿童和青少年的治疗效率和安全性，以及（2）在儿科精神病学临床试验的方法和应用中招募和培训初级科学家。最初的K24奖的重点是焦虑症，更普遍地是在比较治疗试验和临床试验方法上，于2003年结束。在此期间，March博士将发表100多个手稿。成功结束了两个，并发起了三项（也许多达五个）NIMH资助的临床试验。对于儿童和青少年的精神科医生，开发的方法论专业知识与众不同；并成功地指导了二十多名初级和中级研究人员。因此，March博士不仅仅填补了K24计划公告的主要目的，该公告强调了以患者为导向的研究和指导活动中的科学生产力。该竞争性延续申请列出了研究，教学和指导议程，旨在阐明K24奖的附加值。研究议程包括ADHD，抑郁，自杀，焦虑症和强迫症的治疗结果研究，特别关注K24在促进次级分析中的作用。在研究议程中，教义议程规定了SAS编程语言，神经影像学和精神遗传学的培训。指导议程规定了在儿童和青少年精神病学领域的持续和新的指导/咨询活动以及领导领域。通过以非研究患者的护理和行政职责的100％努力提供稳定的薪水支持，K24竞争性延续将维持和促进对精神病儿童和青少年的诊断和治疗的实践和理论贡献。