Family Based Treatment of Early Childhood OCD

儿童早期强迫症的家庭治疗

• 批准号: 7664980
• 负责人: JOHN S MARCH
• 金额: $ 26.52万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7664980
• 关键词: Acute; Address; Adolescent; Affect; Aftercare; Age; Behavior Therapy; Behavioral; Characteristics; Child; Childhood; Chronic; Client; Cognitive; Comorbidity; Development; Drops; Exploratory/Developmental Grant; Family; Family Characteristics; Goals; Health system; Hospitals; Intervention; Left; Location; Maintenance; Mediator of activation protein; Mental Health; Mind; Obsessive-Compulsive Disorder; Outcome; Parents; Patients; Pattern; Pharmaceutical Preparations; Population; Prevention; Psychopathology; Quality of life; Randomized; Randomized Controlled Trials; Relapse; Relative (related person); Relaxation; Relaxation Therapy; Research; Rhode Island; Risk; Ritual compulsion; Site; Symptoms; Testing; Time; Work; Youth; active method; aged; base; cognitive behavior therapy; comparative efficacy; compliance behavior; disability; early childhood; follow-up; functional disability; knowledge base; medical schools; premature; programs; psychosocial; response; socioeconomics; therapy development; treatment effect; treatment program; treatment response

DESCRIPTION (provided by applicant): Childhood-onset Obsessive Compulsive Disorder (OCD) is a chronic psychiatric disturbance that affects approximately 2-4% of children. Despite the significant risk of pervasive and compounding problems for this population, current cognitive-behavioral interventions for youth with OCD do not address the unique features of OCD in young children (ages 5-8), including: cognitive developmental differences, family context, unique symptom correlates, and a family's initial contact with the mental health system. To fill this critical gap in the knowledge base, our research group completed preliminary empirical testing for a manualized family-based cognitive-behavioral treatment (CBT) for OCD in young children. Results of the study indicate that the active treatment was associated with a moderate treatment effect. With this encouraging work as our starting point, we now propose a randomized controlled efficacy study of our family-based CBT program for young children with OCD. The proposed research aims to: (1) Compare the relative efficacy of family-based CBT to family- based Relaxation Treatment (RT) in reducing OCD symptoms in young children (aged 5-8) over 14 weeks of acute treatment, and (2) Compare the relative efficacy of family-based CBT to family based RT in reducing associated disability (functional impairment and quality of life) in young children (aged 5-8) over 14 weeks of acute treatment. Secondary aims are to: (3) Explore potential moderators and mediators of response to treatment, (4) Explore differences in time course of response, use of ASAP sessions, rates of premature termination, and drop out rates between CBT and RT over 14-weeks of acute treatment, and (5) Explore the impact of CBT and RT over a 12-month naturalistic follow-up interval on OCD symptoms, functioning, relapse rates, and utilization of other treatments. Notably, this research: (1) will evaluate outcome beyond OCD symptom reduction, including functional impairment and quality of life; (2) will examine mechanisms of change during treatment; (3) will examine time course and maintenance of response; (4) will evaluate pre- treatment patient and family characteristics that may affect treatment response and (5) represents a first step towards dissemination by evaluating the generalizability of findings across three ethnically and socioeconomically diverse sites.

描述（由申请人提供）：儿童期强迫症（OCD）是一种慢性精神病，影响约2-4％的儿童。尽管对该人群存在普遍性和复杂问题的巨大风险，但针对强迫症的青年的认知行为干预措施并未解决幼儿中强迫症的独特特征（5-8岁），包括：认知发展差异，家庭环境，独特的症状，独特的症状相关以及家庭与心理健康系统的初始接触。为了填补知识库中的这一关键差距，我们的研究小组完成了针对年幼儿童的OCD的基于家庭的认知行为治疗（CBT）的初步经验测试。研究结果表明，主动治疗与中等治疗效果有关。由于这项令人鼓舞的工作是我们的起点，我们现在建议对我们的家庭CBT计划进行一项随机对照疗效研究，针对OCD幼儿。 The proposed research aims to: (1) Compare the relative efficacy of family-based CBT to family- based Relaxation Treatment (RT) in reducing OCD symptoms in young children (aged 5-8) over 14 weeks of acute treatment, and (2) Compare the relative efficacy of family-based CBT to family based RT in reducing associated disability (functional impairment and quality of life) in young children (aged 5-8) over 14 weeks of acute 治疗。次要目的是：（3）探索对治疗反应的潜在主持人和介体，（4）探索时间的响应时间差异，使用ASAP会话，过早终止率以及CBT和RT之间的急性治疗率和RT之间的差异，以及（5）探索CBT和RT对cbt和RT的影响，并探索CBT和RT的影响范围，并在自然方面进行促进范围的范围。其他治疗方法。值得注意的是，这项研究：（1）将评估超出强迫症症状的结果，包括功能障碍和生活质量； （2）将检查治疗过程中的变化机制； （3）将检查时间课程和响应的维护； （4）将评估可能影响治疗反应的治疗前患者和家庭特征，（5）代表通过评估在三个种族和社会经济上不同地点的发现的普遍性来传播的第一步。