Development of research capacity for AIDS and TB in Samara Oblast, Russia

俄罗斯萨马拉州艾滋病和结核病研究能力的发展

• 批准号: 7079055
• 负责人: YANINA BALABANOVA
• 金额: $ 7.91万
• 依托单位: SAMARA REGIONAL TUBERCULOSIS SERVICE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7079055
• 关键词: AIDS education /prevention; Commonwealth of Independent States; disease /disorder prevention /control; epidemiology; international cooperation; training; tuberculosis

Description: (provided by applicant): Samara Oblast is a region of Russia with a significant emerging HIV epidemic particularly in prisons and it has one of the highest rates of multiple drug resistant tuberculosis (TB) in the world. The global objective is to develop local capacity and plan collaborative research to address public health and clinical problems at the focus of the HIV and TB epidemics. Specifically we would: (1) develop the partnership to maximize the training opportunities in the field of AIDS/TB research that can be provided by each partner; (2) identify the training gaps and needs across the main clinical and nursing groups, administrative, scientific and training resources in order develop a plan to address these needs to how training of different professional groups can be integrated to ensure that the aggregate training is greater than the sum of its parts; (3) maximize the interaction and develop the most appropriate research strategies with one or more partners to address key questions relating to the application of clinical care, to benefit those already infected with HIV and/or TB and measures to prevent or reduce TB and other opportunistic infections in HIV patients; (4) plan the key studies needed to establish strong baseline data for the conventional and molecular epidemiology of HIV including clade analysis and the presence of drug resistant strains particularly in key sentinel groups;(5) develop stronger interactions between social and health-based care groups to address the underlying social problems (eg IVDU, alcoholism); (6) plan the development of an HIV and Opportunistic Infections Research Laboratory in Samara Oblast, Russia; (7) develop a long-term plan for development of local research capacity using the knowledge and resources gained from the ICOHRTA program to achieve future goals. Further research would include the development of: (a) sentinel surveillance of HIV epidemic; (b) clade and drug resistance analysis of HIV strains region-wide; (c) baseline analysis, and prevention of respiratory, gastroenterological and systemic opportunistic infections in HIV positive people; (d) assessment of the need of rapid molecular testing; (e) analysis of sexual and drug behavior and HIV-related stigma and (f) development of HIV and Opportunistic Infections laboratory in Samara. The proposal will lead to increased local capacity in the areas of HIV and TB disease control. Public information: This proposal will facilitate collaborative work with NIH and build local research capacity in AIDS and TB.

描述：（由申请人提供）：萨马拉州是俄罗斯艾滋病毒流行严重的地区，特别是在监狱中，并且是世界上多重耐药结核病 (TB) 发病率最高的地区之一。全球目标是发展当地能力并规划合作研究，以解决艾滋病毒和结核病流行的公共卫生和临床问题。具体来说，我们将：（1）发展伙伴关系，以最大限度地增加每个伙伴可以提供的艾滋病/结核病研究领域的培训机会； (2) 确定主要临床和护理群体、行政、科学和培训资源之间的培训差距和需求，以便制定计划来满足这些需求，以及如何整合不同专业群体的培训，以确保培训总量更大大于各个部分的总和； (3) 最大限度地与一个或多个合作伙伴进行互动并制定最合适的研究策略，以解决与临床护理应用相关的关键问题，使已经感染艾滋病毒和/或结核病的人受益，并采取措施预防或减少结核病和其他疾病HIV患者的机会性感染； (4) 规划所需的关键研究，为艾滋病毒的常规和分子流行病学建立强有力的基线数据，包括进化枝分析和耐药菌株的存在，特别是在关键哨兵群体中；(5) 在社会护理和健康护理之间建立更强有力的相互作用解决根本社会问题的团体（例如 IVDU、酗酒）； (6) 计划在俄罗斯萨马拉州建立艾滋病毒和机会性感染研究实验室； (7) 利用从 ICOHRTA 计划获得的知识和资源，制定发展当地研究能力的长期计划，以实现未来目标。进一步的研究将包括发展： (a) 艾滋病毒流行的哨点监测； (b) 全区域艾滋病毒毒株的进化枝和耐药性分析； (c) 基线分析以及艾滋病毒阳性人群呼吸道、胃肠道和全身机会性感染的预防； (d) 评估快速分子检测的需要； (e) 分析性行为和吸毒行为以及与艾滋病毒相关的耻辱；(f) 在萨马拉建立艾滋病毒和机会性感染实验室。该提案将提高当地艾滋病毒和结核病控制领域的能力。公共信息：该提案将促进与 NIH 的合作，并建设当地在艾滋病和结核病方面的研究能力。