Image-Guided Laser Therapy for Barrett's Esophagus

巴雷特食管的图像引导激光治疗

• 批准号: 7249110
• 负责人: Benjamin James Vakoc
• 金额: $ 11.85万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7249110
• 关键词: Ablation; Accounting; Address; Adenocarcinoma; Anatomy; Animals; Asses; Barrett Esophagus; Biological; Biomedical Research; Biometry; Cancer Biology; Catheters; Clinical; Clinical Research; Complement; Consensus; Country; Data; Depth; Development; Disease; Disease regression; Dysplasia; Esophageal; Esophageal Adenocarcinoma; Esophageal mucous membrane; Esophagus; Ethics; Family suidae; Funding; Future; Gastrointestinal Endoscopy; General Hospitals; Goals; Health Sciences; Histology; Histopathology; Human; Image; In Situ; In Vitro; Incidence; Injury; Laser injury; Lasers; Lead; Lesion; Life; Local Therapy; Low-Level Laser Therapy; Malignant Neoplasms; Maps; Massachusetts; Measurement; Mentorship; Methods; Monitor; Morbidity - disease rate; Operative Surgical Procedures; Optical Methods; Optics; Outcome; Pathologic; Pathology; Patients; Phase; Physics; Physiology; Pilot Projects; Premalignant; Preparation; Reflux; Research; Research Design; Research Personnel; Research Training; Resolution; Safety; Sedation procedure; Solid; Specimen; System; Techniques; Technology; Testing; Therapeutic; Thick; Time; Tissues; Training; Translations; base; cancer therapy; design; experience; heat injury; human study; human subject; improved; in vitro Model; in vivo; instrumentation; medical schools; mortality; new technology; novel; optical imaging; prevent; programs; systems research

DESCRIPTION (provided by applicant): Laser ablation therapy has been used to treat pre-malignant lesions of the esophagus with the goal of preventing progression to adenocarcinoma. Existing laser ablation approaches, however, lack the precision necessary to target only the pathologic tissue while sparing neighboring healthy tissue, resulting in significant complications and reduced efficacy. The research focus of this K25 application is to develop and test in vivo a novel endoscopic laser therapy system capable of conforming local therapy to in situ measurements of local anatomy and physiology. The breadth of this research will provide an outstanding contextual training experience, highlighting the methods and conduct of biomedical and clinical research that will complement the candidate's existing expertise in physics and optical technologies. The research training component will occur within the Wellman Center for Photomedicine at the Massachusetts General Hospital under the primary mentorship of Dr. Bouma, a leader in the field of biomedical optics and translational clinical research. Research will initially focus on the in vitro testing of the system capabilities, which will provide training in the methods and interpretation of histopathology as well as the handling of biological tissues. Subsequent in vivo studies of the technical capabilities and safety of the system will provide training in the ethics and conduct of live animal and human studies. Complementary coursework offered at the Harvard Medical School and the Harvard-MIT Division of Health Sciences and Technology will enable the candidate to develop a solid background in cancer biology, cancer treatment, and biostatistics. The training and preliminary data provided in this proposal will enable the candidate to prepare applications for funding that will enable a transition to independent research focusing on the translation of novel technologies to clinical practice. The immediate focus of the proposed research is to develop new methods capable of precise and comprehensive treatment of esophageal pathology prior to the onset of adenocarcinoma. Since esophageal adenocarcinoma is a prevalent disease associated with high morbidity and dismal survival, an improved therapeutic approach that addresses the shortcomings of currently available therapies will make a significant impact.

描述（由申请人提供）：激光消融疗法已用于治疗食道的恶性病变，目的是防止进展到腺癌。然而，现有的激光消融方法缺乏仅针对病理组织的精确度，同时避免了邻近的健康组织，从而导致明显的并发症和疗效降低。该K25应用的研究重点是在体内开发和测试一种新型的内窥镜激光治疗系统，能够使局部疗法对局部解剖学和生理学进行原位测量。这项研究的广度将提供出色的上下文培训经验，强调生物医学和临床研究的方法和行为，这些方法将补充候选人在物理和光学技术方面的现有专业知识。研究培训组成部分将发生在马萨诸塞州综合医院的Wellman摄影医院中心，该中心是Bouma博士的主要指导，Bouma博士是生物医学光学和转化临床研究领域的领导者。研究最初将集中在系统能力的体外测试上，该测试将在组织病理学的方法和解释以及生物组织的处理方面提供培训。随后对系统技术能力和安全性的体内研究将提供有关活动物和人类研究的伦理和行为的培训。哈佛医学院和哈佛大学卫生科学和技术部提供的补充课程将使候选人能够在癌症生物学，癌症治疗和生物统计学方面发展稳固的背景。本提案中提供的培训和初步数据将使候选人能够为资金准备申请，从而使人们能够过渡到独立研究，重点是将新技术转化为临床实践。 拟议研究的直接重点是开发能够在腺癌发作之前对食管病理学进行精确和全面治疗的新方法。由于食管腺癌是一种与高发病率和衰退生存有关的普遍疾病，因此一种改进的治疗方法可以解决当前可用疗法的缺点，将产生重大影响。