Multi-level Data and Research Integration for Autism

自闭症的多层次数据和研究整合

• 批准号: 6885508
• 负责人: ALLEN Y. TIEN
• 金额: $ 21.43万
• 依托单位: MEDICAL DECISION LOGIC, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6885508
• 关键词: autism; bioinformatics; clinical research; computer data analysis; computer system design /evaluation; genotype; human data; human genetic material tag; human subject; mental health information system; phenotype

DESCRIPTION (provided by applicant): The goal of this SBIR project is to create a software system ("MultiDataWorks") that addresses major current and future needs of autism researchers. While existing solutions such as ISAAC (Internet System for Assessing Autistic Children) provide repositories for managing data, there is currently no integrated method for collecting and analyzing phenotypic and genetic data together. Like the current form of ISAAC, the proposed system will provide a broad range for data access and functionality, from global collaboration to study-specific, since scientists both collaborate and compete at multiple laboratories and institutions. Unlike ISAAC, however, the software will be flexible and easily configurable in order to manage the collection and analysis of heterogeneous data and meet evolving scientific needs. The integration of genetic and phenotypic data requires sophisticated software engineering solutions. The approach here will utilize a model-driven architecture (MDA), which unifies and enables representation and storage of various types of knowledge in a central model, which, in turn, can generate large portions of system software code automatically. The MDA approach makes the implementation of software systems that handle complex data and processes much more practical. To develop and evaluate the proposed software system, MDLogix will work in close partnership with the Cure Autism Now (CAN) Foundation and the Autism Genetics Resource Exchange (ACRE). From a user perspective, the MultiDataWorks system will have three major parts: (1) an enhanced version of ISAAC ("ISAAC-PM"); (2) a genetic data interchange and storage module ("GeneDataWorks"); and (3) integrated querying of combined genetic and phenotypic data ("DataTect"). From the software engineering perspective, the software will consist of a single unified data model deployed to the Internet and linked to users through a carefully layered and easily evolved architecture.

描述（由申请人提供）：该 SBIR 项目的目标是创建一个软件系统（“MultiDataWorks”），以满足自闭症研究人员当前和未来的主要需求。虽然 ISAAC（评估自闭症儿童的互联网系统）等现有解决方案提供了用于管理数据的存储库，但目前还没有用于收集和分析表型和遗传数据的集成方法。与 ISAAC 的当前形式一样，拟议的系统将提供广泛的数据访问和功能，从全球协作到特定研究，因为科学家们在多个实验室和机构中进行合作和竞争。然而，与 ISAAC 不同的是，该软件将灵活且易于配置，以便管理异构数据的收集和分析并满足不断变化的科学需求。遗传和表型数据的整合需要复杂的软件工程解决方案。这里的方法将利用模型驱动架构（MDA），它统一并支持在中央模型中表示和存储各种类型的知识，而中央模型又可以自动生成大部分系统软件代码。 MDA 方法使得处理复杂数据和流程的软件系统的实现更加实用。为了开发和评估拟议的软件系统，MDLogix 将与 Cure Autism Now (CAN) Foundation 和 Autism Genetics Resource Exchange (ACRE) 密切合作。从用户的角度来看，MultiDataWorks系统将由三个主要部分组成：（1）ISAAC的增强版（“ISAAC-PM”）； (2) 遗传数据交换和存储模块（“GeneDataWorks”）； (3)组合遗传和表型数据的综合查询（“DataTect”）。从软件工程的角度来看，该软件将由部署到互联网的单一统一数据模型组成，并通过精心分层且易于演进的架构与用户链接。