COBRE in Neurodevelopment and Its Disorders

COBRE 在神经发育及其疾病中的作用

基本信息

批准号：
10556537
负责人：
Christopher W Cowan
金额：
$ 223.28万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2028-02-29
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10556537
关键词：
Animal Model Animals Area Attention deficit hyperactivity disorder Basic Science Behavioral Bioinformatics Biological Markers Biology Brain Brain imaging Centers of Research Excellence Child Clinical Clinical Research Collaborations Communities Complement Department chair Development Diagnosis Disease Environment Epilepsy Equipment Evaluation Explosion Faculty Fostering Functional disorder Funding Future Gene Expression Genetic Genomics Goals Grant Health Human Image Imaging technology Impaired cognition Individual Institution Intellectual functioning disability Interdisciplinary Study Investments Leadership Link Medical Medicine Mentors Mission Modernization Molecular Molecular Neurobiology Mus Neurodevelopmental Disability Neurodevelopmental Disorder Neurosciences Research Pathology Peer Review Personal Satisfaction Phenotype Pilot Projects Psychologist Publications Research Research Infrastructure Research Personnel Research Training Resources Scientist Source South Carolina Symptoms Systems Development Technology Training Translational Research Traumatic injury United States National Institutes of Health Universities Vision Writing autism spectrum disorder behavioral phenotyping biomarker discovery brain research career career development cell type college computer infrastructure disorder risk economic cost experience human model improved in vivo individuals with autism spectrum disorder innovation member multidisciplinary neural neurodevelopment new growth novel novel therapeutic intervention programs recruit social success synergism training opportunity

项目摘要

OVERALL – PROJECT SUMMARY The overall goal of the Center of Biomedical Research Excellence (COBRE) in Neurodevelopment and Its Disorders (CNDD) is to enhance research capacity by enabling outstanding multidisciplinary collaborative research in neurodevelopmental disorders (NDD) at the Medical University of South Carolina (MUSC). This area is of importance to the state of South Carolina as the diagnosis rate and proportion of individuals with Autism Spectrum Disorder (ASD) who have significant cognitive impairments is estimated to be higher than those of the nation. The specific aims are to: 1) Mentor a strong cadre of early career scientists to become independently funded investigators in NDD research; 2) Establish sustainable core resources to support modern NDD research while leveraging institutional investments; and 3) Promote sustainability of the CNDD through creation of multidisciplinary research programs, rigorous evaluation, strategic improvement, and mission alignment with other Centers at MUSC and across the state of South Carolina. The Center is led by a multidisciplinary team, composed of a department chair with extensive experience in molecular neurobiology, an expert in the field of complement biology, and a clinical psychologist focused on ASD research within the MUSC College of Medicine, coalescing resources to achieve their overarching objective of building a critical mass of funded investigators that will allow MUSC to compete for future external peer-reviewed programmatic grant support. This application highlights four of our most outstanding Junior Investigators (JIs) who will benefit from an innovative multiple source mentoring plan which features both internal and external mentors. We anticipate each of these JIs to transition to independent NIH funding within the first three years of the project. The CNDD also includes three Cores that will support not only the JIs but also NDD investigators throughout MUSC. Scientific cores include the: 1) Genomic and Bioinformatic Core, which will provide technical assistance, computational infrastructure, and training opportunities; 2) Mouse Behavioral Phenotyping Core, which will provide access to and training in behavioral analyses of mice; and 3) Small Animal Brain Imaging Core, which will provide access to modern brain imaging technologies that can extend the scope and impact of neurodevelopment research. Additionally, the CNDD will foster collaborations among NDD researchers by promoting interdisciplinary scientific exchange through our enrichment activities and build research capabilities through our Pilot Project Program. With NIH and institutional support, the expansion of research capabilities, development of JIs, and promotion of integrative, multidisciplinary NDD research programs, the proposed CNDD will substantially enhance basic, translational, and clinical research at MUSC. Together with key institutional investments across the state, the CNDD will enable the formation of a sustainable, thriving hub of world-class research in neurodevelopment and its disorders in South Carolina.

总体而言——项目概要神经发育卓越生物医学研究中心（COBRE）的总体目标及其疾病（CNDD）旨在通过实现杰出的多学科协作来增强研究能力南卡罗来纳医科大学 (MUSC) 的神经发育障碍 (NDD) 研究。对南卡罗来纳州非常重要，因为自闭症患者的诊断率和比例据估计，患有严重认知障碍的谱系障碍 (ASD) 患者的患病率要高于正常人具体目标是： 1）指导一批强有力的早期职业科学家成为独立的科学家。 2）建立可持续的核心资源来支持现代NDD研究同时利用机构投资；以及 3) 通过创建 CNDD 来促进可持续发展多学科研究计划、严格评估、战略改进和使命协调 MUSC 和南卡罗来纳州的其他中心该中心由多学科团队领导，由一位在分子神经生物学领域拥有丰富经验的系主任、该领域的专家组成补充生物学，以及 MUSC 医学院专注于 ASD 研究的临床心理学家，整合资源以实现建立足够数量的资助调查人员的总体目标这将使 MUSC 能够竞争未来的外部同行评审计划拨款支持。重点介绍了我们四位最杰出的初级研究员 (JI)，他们将受益于创新的多重研究我们期望这些 JI 中的每一个都包含内部和外部导师的来源指导计划。在该项目的前三年内过渡到独立的 NIH 资助还包括三个。不仅支持 JI，还支持整个 MUSC 科学核心的 NDD 研究人员。 1) 基因组和生物信息学核心，将提供技术援助、计算基础设施、和培训机会；2) 小鼠行为表型核心，它将提供以下方面的访问和培训：小鼠的行为分析；3) 小动物大脑成像核心，这将提供对现代大脑的了解成像技术可以扩大神经发育研究的范围和影响。 CNDD 将通过促进跨学科科学交流来促进 NDD 研究人员之间的合作通过我们的丰富活动并通过我们与 NIH 的试点项目计划建立研究能力。和机构支持、研究能力的扩展、联合研究的发展以及综合性的促进，多学科 NDD 研究计划，拟议的 CNDD 将大大加强基础、转化、 CNDD 将与 MUSC 的关键机构投资一起实现这一目标。形成一个可持续、繁荣的世界级神经发育及其疾病研究中心南卡罗来纳州。