Spatiotemporal Brain Imaging of Alcohol Effects on Inhibitory Control

酒精对抑制控制影响的时空脑成像

• 批准号: 7321706
• 负责人: KSENIJA MARINKOVIC
• 金额: $ 47.44万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-10 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7321706
• 关键词: Acute; Affect; Alcohol abuse; Alcohol dependence; Alcoholic Intoxication; Alcohols; Anterior; Area; Attenuated; Behavior; Behavioral; Brain; Brain imaging; Characteristics; Complex; Condition; Conflict (Psychology); Coupling; Cues; Dependence; Disruption; Dose; Electroencephalography; Electromagnetics; Evaluation; Exhibits; Feedback; Functional Magnetic Resonance Imaging; Gender; Goals; Heavy Drinking; Impairment; Individual; Intoxication; Investigation; Lateral; Magnetic Resonance Imaging; Magnetoencephalography; Manuals; Measures; Methods; Modality; Monitor; Motor; Movement; Multimodal Imaging; Nature; Output; Parietal; Pattern; Placebos; Preparation; Process; Research; Research Personnel; Research Project Grants; Resolution; Risk Factors; Role; Self-control as a personality trait; Signal Transduction; Specific qualifier value; Staging; Stimulus; Stream; System; Techniques; Time; Woman; Work; alcohol effect; alcohol sensitivity; cingulate cortex; cognitive control; design; drinking; goal oriented behavior; hazard; hemodynamics; indexing; men; neural circuit; neuroimaging; neurophysiology; problem drinker; programs; relating to nervous system; response; restraint; selective attention; spatiotemporal; stimulus processing; trafficking; trait

DESCRIPTION (provided by applicant): This is a revised application for an NIAAA-sponsored Research Project Grant (R01) entitled "Spatiotemporal Brain Imaging of Alcohol Effects on Inhibitory Control" Problem drinkers often exhibit deficits in self-control and sustained goal-oriented behavior. This observation is consistent with the evidence suggesting that acute intoxication interferes with the ability to evaluate conflicting task demands, inhibit impulsive responses and execute cognitive control. These impairments may result in a decreased ability to exert self restraint, contributing to increased drinking and alcohol dependence. The overall goal of the proposed research is to use multimodal brain imaging to identify the temporal ("when") and spatial ("where") characteristics of the neural circuits subserving inhibitory control and to determine their sensitivity to the acute effects of alcohol. Functional magnetic resonance imaging (fMRI) will be used in order to determine where the alcohol-induced induced changes are occurring. Excellent temporal resolution of magneto- (MEG) and electroencephalography (EEG) will elucidate the timing of these abnormalities. Effects of alcohol on both "input" (stimulus evaluation) and "output" (response preparation, inhibition and execution) will be studied concurrently and with the multimodal neuroimaging approach. It is hypothesized that alcohol intoxication primarily disrupts integrated prefrontal circuitry that exerts inhibitory top-down control on behavior. Since the strategic control is exerted via a complex system involving multiple stages of these integrated "input" and "output" streams in addition to error monitoring and regulatory feedback loops, multimodal imaging approach may reveal the real-time stages of the underlying neural areas and their sensitivity to alcohol intoxication. Healthy subjects will serve as their own controls as they participate in alcohol and placebo conditions in three tasks probing inhibitory control and selective attention. In addition, dispositional traits obtained in the same individuals will be considered together with the neurophysiological indices and may reveal the idiosyncratic aspects of alcohol effects on the brain and the multidimensional nature of inhibitory control. This research has ramifications for traffic- or work-related hazards and may elucidate the alcohol-induced impairment of self-regulatory functions contributing to alcohol abuse and dependence

描述（由申请人提供）：这是对NIAAA赞助的研究项目赠款（R01）的修订申请，题为“酒精对酒精对抑制性控制的时空脑成像”通常在自我控制和持续面向目标的行为方面表现出缺陷。该观察结果与表明急性中毒会干扰评估矛盾的任务需求，抑制冲动反应并执行认知控制能力的证据一致。这些障碍可能导致施加自我限制的能力降低，导致饮酒和酒精依赖性增加。拟议研究的总体目标是使用多模式脑成像来识别神经回路的时间（“ whe whe whe”）和空间（“ where”）特征，从而扩散抑制性控制并确定其对酒精急性影响的敏感性。将使用功能磁共振成像（fMRI），以确定酒精诱导的诱导的变化发生在哪里。磁磁（MEG）和脑电图（EEG）的出色时间分辨率将阐明这些异常的时间。酒精对“输入”（刺激评估）和“输出”（响应准备，抑制和执行）的影响将同时研究以及多模式神经影像学方法。假设酒精中毒主要破坏综合的前额叶回路，从而对行为产生抑制作用的控制。由于战略控制是通过复杂的系统施加的，该系统涉及这些集成的“输入”和“输出”流的多个阶段，除了错误监测和调节反馈回路外，多模式成像方法可能会揭示基础神经区域的实时阶段及其对酒精中毒的敏感性。在探测抑制性控制和选择性关注的三个任务中，健康受试者将作为他们自己的控制。此外，将在同一个体中获得的性格性状与神经生理学指数一起考虑，并可能揭示酒精对大脑影响的特质以及抑制性控制的多维性质。这项研究对交通或与工作有关的危害产生了影响，并可能阐明酒精引起的自我调节功能的损害，导致酒精滥用和依赖性