Exploring the role of vitamin transport in insect models of disease vector biology

探索维生素运输在病媒生物学昆虫模型中的作用

基本信息

批准号：
2884651
负责人：
金额：
--
依托单位：
Newcastle University
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2884651
关键词：
Exploring role vitamin transport insect

项目摘要

Vector-borne diseases of plants, livestock and humans are infections transmitted by arthropods feeding on host plants or animals. These diseases have huge worldwide economic, social and health costs.Micronutrients such as vitamins are essential for all forms of animal life. However, many invertebrates thrive despite feeding exclusively on diets deficient in vitamins. Adequate nutrition is achieved via mutualistic relationships with heritable microbes which provide the micronutrients lacking in diet. This obligate nutritional symbiosis is most striking in insects feeding exclusively on vitamin deficient vertebrate blood or plant sap, insects that often act as vectors of human/livestock/plant diseases and have huge global economic impacts on crop production, food biosecurity, animal and human health.Hypothesis: Molecular mechanisms of vitamin transport are fundamental for the persistence of endosymbiosis in obligate blood- and sap- feeding insects and, thus, the success of many invertebrate disease vectors.Vitamin provision is central to endosymbiotic relationships and host insect success, but little is known about the molecular mechanisms involved in vitamin transport in insects. How are microbe-derived vitamins delivered to the bacteriocyte cytosol across the symbiosomal membrane, or to insect haemolymph across the bacteriocyte plasma membrane? By analysing recent genomic/transcriptomic information from blood- and sap-feeding insects, candidate vitamin transporters will be identified and characterised functionally. Understanding the molecular basis of endosymbiotic relationships will shed light on a fundamental aspect of arthropod biology and underpin the development of novel disease vector control strategies centred on transporter biology.Molecules, Cells and Industrial Biotechnology

植物、牲畜和人类的媒介传播疾病是由以宿主植物或动物为食的节肢动物传播的感染。这些疾病在全球范围内造成巨大的经济、社会和健康成本。维生素等微量营养素对于所有形式的动物生命都至关重要。然而，许多无脊椎动物尽管只以缺乏维生素的饮食为食，但仍能茁壮成长。充足的营养是通过与遗传微生物的互惠关系来实现的，这些微生物提供了饮食中缺乏的微量营养素。这种专性营养共生在专门以缺乏维生素的脊椎动物血液或植物汁液为食的昆虫中最为显着，这些昆虫通常是人类/牲畜/植物疾病的媒介，并对作物生产、粮食生物安全、动物和人类健康产生巨大的全球经济影响假设：维生素转运的分子机制对于专性吸血和吸汁昆虫中内共生的持续存在以及许多无脊椎动物疾病的成功至关重要维生素供应对于内共生关系和宿主昆虫的成功至关重要，但人们对昆虫维生素运输的分子机制知之甚少。微生物来源的维生素如何穿过共生体膜传递至细菌细胞胞浆，或穿过细菌细胞质膜传递至昆虫血淋巴？通过分析来自吸血和汁液昆虫的最新基因组/转录组信息，将鉴定候选维生素转运蛋白并对其功能进行表征。了解内共生关系的分子基础将揭示节肢动物生物学的一个基本方面，并支持以转运生物学为中心的新型病媒控制策略的发展。分子、细胞和工业生物技术