Substance Abuse in ADHD Girls

多动症女孩的药物滥用

• 批准号: 6845719
• 负责人: Timothy E Wilens
• 金额: $ 21.63万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-05 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6845719
• 关键词: academic achievement; adolescence (12-20); alcoholism /alcohol abuse; attention deficit disorder; behavior prediction; behavioral /social science research tag; bipolar depression; comorbidity; conduct disorder; disease /disorder onset; disease /disorder proneness /risk; family genetics; family structure /dynamics; female; gender difference; human subject; mental health epidemiology; neuropsychological tests; patient oriented research; smoking; socioenvironment; substance abuse epidemiology; substance abuse related disorder; tobacco abuse; women' s health; young adult human (21-34)

This is the first resubmission of an R01 application, 1 R01 DA14419-01, that is a response to a PA (97-043) encouraging research on the origins and pathways to substance abuse (SA). A mixed body of evidence suggests that SA is frequently preceded by childhood attention-deficit/hyperactivity disorder (ADHD) and associated comorbid disorders. The aim of this proposal is to test hypotheses about the co-occurrence of SA in ADHD adolescent girls growing up and their high-risk siblings. We are proposing to study a group of girls available from an NIMH funded five year, family-based, controlled follow-up study of girls with ADHD currently underway with a focus on SA. At baseline assessment, we ascertained 140 ADHD and 120 normal control girls from psychiatric and non-psychiatric settings with 464 and 402 first degree biological relatives, respectively. We now propose a five-year study that will re-examine the probands and families five years after their baseline assessment with a particular emphasis on SA, thus capturing these adolescents as they are beginning to pass through the risk for SA. We have two Main Aims: 1) To characterize SA in ADHD girls growing up, and 2) To determine predictors of SA in ADHD girls growing up. In our preliminary work, we have begun to address issues related to the overlap of SA and ADHD in boys and girls that are the focus of the proposed work. We view the proposed extension of our work as an essential step for several reasons: this work will be the first, prospective high risk family-based study of SA in ADHD girls; we will have extensive information on a well characterized group of children ascertained from medical and psychiatric settings spanning five years; and psychiatric comorbidity within ADHD was not excluded allowing analysis of its influence on later SA. Given the high prevalence of ADHD, its related comorbid disorders, and its frequent persistence into adulthood, the proposed study will shed light on ADHD adolescent and young adult females at highest risk for SA. Since ADHD is treatable and identifiable in early years, these data will provide valuable information to formulate prevention interventions. Thus, the research, approach, and goals of this R01 application are consistent with those underscored in the PA and by the Institute of Medicine as being of the highest research priority.

这是 R01 申请（1 R01 DA14419-01）的首次重新提交，该申请是对鼓励研究药物滥用 (SA) 起源和途径的 PA (97-043) 的回应。 多种证据表明，SA 之前经常出现儿童注意力缺陷/多动障碍 (ADHD) 和相关的共病。 该提案的目的是检验关于 ADHD 少女及其高危兄弟姐妹中同时发生 SA 的假设。 我们提议对一组女孩进行研究，该研究来自 NIMH 资助的为期五年、以家庭为基础的对照随访研究，该研究目前正在进行中，重点是 SA 上的 ADHD 女孩。 在基线评估中，我们确定了来自精神病学和非精神病学环境的 140 名 ADHD 女孩和 120 名正常对照女孩，分别有 464 名和 402 名一级生物学亲属。我们现在提出一项为期五年的研究，将在基线评估五年后重新检查先证者和家庭，特别强调 SA，从而在这些青少年开始经历 SA 风险时捕获他们。 我们有两个主要目标：1) 描述 ADHD 女孩成长过程中的 SA 特征，2) 确定 ADHD 女孩成长过程中 SA 的预测因子。 在我们的初步工作中，我们已经开始解决与男孩和女孩的 SA 和 ADHD 重叠相关的问题，这是拟议工作的重点。我们认为扩大我们的工作的提议是一个重要的步骤，原因如下：这项工作将是第一个针对 ADHD 女孩的 SA 的前瞻性高风险家庭研究；我们将获得有关五年内医疗和精神病学环境中确定的一组特征明确的儿童的大量信息；不排除 ADHD 内的精神共病，以便分析其对后期 SA 的影响。 鉴于 ADHD 及其相关合并症的高患病率，以及其频繁持续到成年期的情况，拟议的研究将揭示 ADHD 青少年和年轻女性患 SA 风险最高的情况。 由于多动症在早期是可以治疗和识别的，因此这些数据将为制定预防干预措施提供有价值的信息。 因此，该 R01 申请的研究、方法和目标与 PA 和医学研究所强调的最高研究优先级一致。