Comparative Toxicogenomics Database (CTD)

比较毒理基因组学数据库 (CTD)

• 批准号: 7089611
• 负责人: JAMES Lorenzen BOYER
• 金额: $ 80万
• 依托单位: MOUNT DESERT ISLAND BIOLOGICAL LAB
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-18 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7089611
• 关键词: chemical information system; chemical structure function; data quality /integrity; disease /disorder etiology; environmental contamination; environmental exposure; environmental health; environmental toxicology; gene environment interaction; gene expression; information retrieval; literature citation; microarray technology; molecular biology information system; protein structure function; species difference; toxicology information system

DESCRIPTION (provided by applicant): The goal of this proposal is to establish an authoritative public database, the Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org), that promotes understanding about the effects of environmental chemicals on human health. The etiology of most chronic diseases involves interactions between environmental and genetic factors. Although more than 85,000 chemicals are used in commerce today, the complex molecular mechanisms underlying the actions of most of these chemicals and their effects on human health are poorly understood. In CTD we will present scientifically reviewed information on environmental chemicals, significant genes, and their interactions in vertebrates and invertebrates. The specific aims of this proposal are to: 1) curate and integrate chemical-gene interactions from published literature and high-throughput experimental data (e.g., microarrays); 2) curate cross-species toxicologically important genes and their proteins; and 3) transform the CTD prototype into a robust, production-quality database ready for increased public use and more sophisticated data search and analysis capabilities. CTD will be the first database to focus its curation on chemical-gene interactions and genes of toxicological significance in diverse species to elucidate structure-function correlations. These data will be key to building network models of chemical actions and providing important insights into differences in susceptibility to environmentally-induced toxicity and disease. Insights from CTD will also have important implications for toxicity prediction and environmental regulation. We are developing the publicly available Comparative Toxicogenomics Database (CTD) to promote understanding about the effects of environmental chemicals on human health. CTD will provide information on significant chemicals, genes, and their interactions in vertebrates and invertebrates. These data will provide important insights into the mechanisms of chemical actions and the genetic basis of differential toxicity among organisms and individuals, and will also have important implications for toxicity prediction and environmental regulation.

描述（由申请人提供）：该提案的目的是建立权威性公共数据库，比较毒理学分析组学数据库（CTD; http://ctd.mdibl.org），以促进对环境化学物质对人类健康的影响的了解。大多数慢性疾病的病因涉及环境和遗传因素之间的相互作用。尽管当今的商业中使用了超过85,000种化学物质，但对大多数化学物质作用及其对人类健康的影响的基础的复杂分子机制知之甚少。在CTD中，我们将介绍有关环境化学物质，重要基因及其在脊椎动物和无脊椎动物中的相互作用的科学审查信息。该提案的具体目的是：1）从已发表的文献和高通量实验数据（例如微阵列）中策划和整合化学基因相互作用； 2）策展跨物种在毒理学上重要的基因及其蛋白质； 3）将CTD原型转换为强大的生产质量数据库，准备增加公众使用以及更复杂的数据搜索和分析功能。 CTD将是第一个将其策划集中在多种物种中的化学基因相互作用和毒理学意义基因上的数据库，以阐明结构 - 功能功能相关性。这些数据将是建立化学作用网络模型，并为对环境引起的毒性和疾病的敏感性差异提供重要的见解。 CTD的见解也将对毒性预测和环境调节具有重要意义。我们正在开发公开可用的比较毒物学数据库（CTD），以促进对环境化学物质对人类健康的影响的理解。 CTD将提供有关脊椎动物和无脊椎动物中重要的化学物质，基因及其相互作用的信息。这些数据将提供有关化学作用机制以及生物体和个体差异毒性的遗传基础的重要见解，并且还将对毒性预测和环境调节具有重要意义。