Support for Enhancement Excellence in Research at UPR-RP

支持 UPR-RP 提高卓越研究水平

• 批准号: 7078416
• 负责人: RAFAEL ARCE
• 金额: $ 31.71万
• 依托单位: UNIVERSITY OF PUERTO RICO RIO PIEDRAS
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7078416
• 关键词: Support; Enhancement; Excellence; Research; UPR

DESCRIPTION (provided by applicant): This second supplemental application requests the addition of three regular and one pilot projects to the SCORE Program currently active at the University of Puerto Rico, Rio Piedras. The projects included are three from the Department of Biology and one from Chemistry. Two of these are revised applications according to the critiques reported in summary statements of our SCORE application (Soderquist) and of the first supplemental application (Dominguez). Another is presented from a recently hired evolutionary biologist and quantitative geneticist (Hrbek) and the other is from a junior investigator that participated in the previous grant cycle (Giray). All together complement biomedical research efforts at UPR-RP that have been ongoing for over 33 years under the auspicies of the MBRS program and specifically, strengthen the present SCORE Program which groups 14 regular and 3 pilot projects (10 in Chemistry, 5 in Biology and 2 in Mathematics). Together these new projects aim to conduct competitive research in areas related to (1) replacement and inter-strain conversion of Helicobacteri and amino acids pylori types resulting from the mixing of different human populations, and potential impact on disease, (Dominguez); (2) the understanding of the integration of muscle (motor) with adult behavioural development in a bee model (Giray); (3) the development of a model system for evaluating biomedically relevant complex traits, senescence and developmental diapause, in the fish super family of Aplocheiloide that has evolved these traits in response to environmental pressures (Hrbek), and (4) to the invention and development of new methods for the synthesis of non-racemic amines and amino acids, chiral building blocks which have a wide range of potential applications for the synthesis of pharmaceuticals and complex natural products (Soderquist). These investigations are to be sustained by an ongoing administrative project and by technical and support personnel that include four laboratory technicians and three postdoctoral associates. This enhanced SCORE Program will provide this institution first-rate research and development opportunities as well as a fully supportive research atmosphere and will thus help the participating faculty to increase their biomedical research productivity, scientific competitiveness and peer recognition. Research activities in the program also enhance the existing MARC U*STAR Program and the MBRS-RISE Program at this institution. Progress in the specific aims of each new project and in the overall aims of the program will be evaluated yearly through an established Evaluation Plan.

描述（由申请人提供）：第二份补充申请要求在 SCORE 项目中添加 3 个常规项目和 1 个试点项目，该项目目前在波多黎各大学里奥彼德拉斯分校开展。其中包括三个来自生物系的项目和一个来自化学系的项目。其中两个是根据我们的 SCORE 申请 (Soderquist) 和第一个补充申请 (Dominguez) 的摘要陈述中报告的批评修改的申请。另一个是由最近聘请的进化生物学家和定量遗传学家 (Hrbek) 提出的，另一个是由参与上一个资助周期的初级研究员 (Giray) 提出的。所有这些都补充了 UPR-RP 在 MBRS 计划的支持下持续进行了 33 年多的生物医学研究工作，特别是加强了目前的 SCORE 计划，该计划包括 14 个常规项目和 3 个试点项目（10 个化学项目、5 个生物学项目和 5 个项目）。数学2）。这些新项目旨在共同开展以下领域的竞争性研究：(1) 由于不同人群混合而产生的幽门螺杆菌和氨基酸类型的替代和菌株间转换，以及对疾病的潜在影响（Dominguez）； （2）理解蜜蜂模型（Giray）中肌肉（运动）与成年行为发育的整合； (3)开发用于评估生物医学相关的复杂性状、衰老和发育滞育的模型系统，该系统在Aplocheiloide鱼类超家族中，该家族已经进化出这些性状以响应环境压力(Hrbek)，以及(4)本发明和开发合成非外消旋胺和氨基酸、手性结构单元的新方法，这些材料在药物和复杂天然产物的合成中具有广泛的潜在应用（Soderquist）。 这些调查将由正在进行的行政项目以及包括四名实验室技术员和三名博士后助理在内的技术和支持人员来维持。这一增强的 SCORE 计划将为该机构提供一流的研究和发展机会以及充分支持的研究氛围，从而帮助参与的教师提高他们的生物医学研究生产力、科学竞争力和同行认可。该计划的研究活动还增强了该机构现有的 MARC U*STAR 计划和 MBRS-RISE 计划。每个新项目的具体目标和该计划的总体目标的进展情况将每年通过既定的评估计划进行评估。