Changes in Women's HIV Risk Following Alcohol Treatment

酒精治疗后女性艾滋病毒风险的变化

• 批准号: 6947175
• 负责人: KURT H DERMEN
• 金额: $ 63.95万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6947175
• 关键词: AIDS education /prevention; alcoholism /alcohol abuse therapy; behavior modification; behavior therapy; behavioral /social science research tag; clinical research; condoms; female; high risk behavior /lifestyle; human subject; human therapy evaluation; interview; longitudinal human study; motivation; psychometrics; safe sex /sex abstinence; sex behavior; sex partner; substance abuse related behavior; women' s health

DESCRIPTION (provided by applicant): Women in treatment for alcohol problems are at heightened risk for infection with HIV. Alcohol use may contribute directly or indirectly to risk in this population. Other factors that may contribute to risk include individual-level characteristics (e.g., psychological distress; alcohol expectancies for risky behavior), as well as contextual characteristics associated with specific partners and relationships (e.g., negative partner attitudes toward condom use). Alcohol use and other factors can be conceptualized as operating through their influence on constructs represented in the Information-Motivation-Behavioral Skills (1MB) model of HIV preventive behavior. For the proposed project, an ethnically diverse sample of women entering either outpatient (n = 300) or inpatient (n = 150) treatment for alcohol abuse or dependence will be interviewed on five occasions: shortly after admission to treatment, and 3, 6, 9 and 12 months following the initial interview. Interviews will assess alcohol and other substance use, sexual behavior, and a range of individual and contextual variables that may affect HIV risk. Each interview will include administration of a 90-day Timeline Follow-Back to obtain a retrospective, daily assessment of substance use and sexual behavior, and detailed event assessments for the most recent occurrence of sexual intercourse and for the first occasion of intercourse with the most recent new sexual partner (if any). The proposed research will achieve the following specific aims: (1) To evaluate cross-sectionally, both prior to and following women's entry into treatment, model-derived hypotheses regarding the acute and global relationships of alcohol use and other factors to HIV risk-related behavior (as characterized by non-use of condoms during sexual intercourse, having multiple and/or casual sexual partners, and not discussing risk-related topics prior to having sex); (2) To evaluate prospectively hypotheses regarding the extent to which baseline characteristics are predictive of subsequent change in HIV risk behavior following entry into alcoholism treatment; and (3) To evaluate prospectively hypotheses regarding the extent to which women's treatment participation, exposure to HIV risk-reduction education and counseling, and changes in alcohol use mediate changes in IMB-related constructs and HIV risk-related behavior. The proposed research, guided by empirically supported models of HIV prevention behavior and alcohol effects, will provide a strong foundation for subsequent development of effective, efficient, targeted HIV prevention for women in alcoholism treatment.

描述（由申请人提供）： 接受酒精问题治疗的女性感染艾滋病毒的风险更高。饮酒可能会直接或间接增加该人群的风险。其他可能导致风险的因素包括个人特征（例如，心理困扰；对危险行为的酒精预期），以及与特定伴侣和关系相关的背景特征（例如，伴侣对使用安全套的消极态度）。饮酒和其他因素可以被概念化为通过它们对 HIV 预防行为的信息-动机-行为技能 (1MB) 模型中所代表的结构的影响来发挥作用。对于拟议项目，将对因酗酒或酒精依赖而进入门诊（n = 300）或住院（n = 150）治疗的不同种族女性样本进行五次访谈：入院后不久，以及 3、6、初次面试后的 9 个月和 12 个月。访谈将评估酒精和其他药物的使用、性行为以及一系列可能影响艾滋病毒风险的个人和背景变量。每次访谈将包括进行 90 天的时间线跟踪，以获得对物质使用和性行为的回顾性每日评估，以及对最近发生的性交和与最常发生性交的第一次性交的详细事件评估。最近的新性伴侣（如果有）。拟议的研究将实现以下具体目标：(1) 在妇女接受治疗之前和之后对关于饮酒和其他因素与艾滋病毒风险相关的急性和整体关系的模型衍生假设进行横断面评估行为（其特征是性交时不使用安全套、拥有多个和/或临时性伴侣、以及在发生性行为之前不讨论与风险相关的话题）； (2) 前瞻性评估关于基线特征在多大程度上预测接受酗酒治疗后艾滋病毒危险行为的后续变化的假设； (3) 前瞻性评估关于妇女治疗参与、接受艾滋病毒风险降低教育和咨询以及饮酒改变在多大程度上介导 IMB 相关结构和艾滋病毒风险相关行为变化的假设。拟议的研究以艾滋病毒预防行为和酒精影响的经验支持模型为指导，将为后续在酗酒治疗中为女性制定有效、高效、有针对性的艾滋病毒预防奠定坚实的基础。