2nd International Pathogenesis of Rare Neuroimmunologic Disorders

第二届国际罕见神经免疫性疾病发病机制

• 批准号: 7162413
• 负责人: DOUGLAS A KERR
• 金额: $ 1.5万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162413
• 关键词: immunopathology; meeting /conference /symposium; nervous system disorder; orphan disease /drug; travel

Neuroimmunologic disorders are a loosely defined group of disorders in which there is an immunemediated injury of the nervous system that include the following: polymyositis, myasthenia gravis (MG), inflammatory polyneuropathies, transverse myelitis, HTLV-1 associated myelopathy, stiff person syndrome (SPS), neuromyelitis optica (NMO), optic neuritis (ON), multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), Hashimoto?s encephalitis, Rasmussen?s encephalitis, paraneoplastic encephalomyelitis (PE), and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Also included in this list are neurologic manifestations of sarcoidosis, Sjogren?s syndrome, infections (i.e. JC virus, meningitis and HIV) and responses of manipulating the immune system (immune reconstitution syndrome). Though each disorder is unique, there are shared immunopathogenic mechanisms among many of them that justify their study as entities on a single spectrum. To further explore this and to continue the collaborations forged at a similar symposium in 2004, we have organized the 2 2nd nd international ?Pathogenesis of Rare Neuroimmunologic Disorders? workshop to be held at the Sheraton in Baltimore MD from July 20th-22nd, 2006. The workshop will not be disease oriented, but rather, mechanism oriented, and will involve discussions of many neuroimmunologic disorders as they pertain to mechanisms of autoimmunity in the nervous system. This workshop will focus on rare neuroimmunologic disorders, rather than on the most common disease in this group, MS. However, participants will be invited to discuss advances in MS specifically as these advances inform and educate research in other neuroimmunologic disorders. Participants will explore the following common themes: Genetics and triggering mechanisms; humoral contributions to autoimmunity; cellular contributions to autoimmunity, migration of immune cells; innate immune contributions; neuroprotection; neural-immune cross talk; remyelination; novel imaging and emerging immunotherapies. Participants will learn where the disorders are similar and therefore benefit from similar therapeutic approaches; and where they are distinct, elucidating the need for unique treatment strategies. The central premise of the symposium is that by discussing unique and shared pathologic processes of a group of rare disorders, participants will stimulate novel, collaborative investigations necessary to advance understanding of these disorders. The workshop will be small and interactive, distinguishing it from other larger symposia which typically emphasize the more common neuroimmunologic disorders (especially multiple sclerosis) and are largely didactic. The workshop will solicit participation from both senior and junior scientists/students in order to stimulate long-term research in these disorders. The proceedings will be disseminated in the medical literature.

神经免疫性疾病是一组松散定义的疾病，其中存在免疫介导的疾病 神经系统损伤，包括：多发性肌炎、重症肌无力 (MG)、 炎性多发性神经病、横贯性脊髓炎、HTLV-1相关性脊髓病、僵人综合征 (SPS)、视神经脊髓炎 (NMO)、视神经炎 (ON)、多发性硬化症 (MS)、急性播散性 脑脊髓炎 (ADEM)、桥本脑炎、拉斯穆森脑炎、副肿瘤性脑炎 脑脊髓炎（PE）和与链球菌相关的儿童自身免疫性神经精神疾病 感染（熊猫）。此列表中还包括结节病、干燥病的神经系统表现 综合征、感染（即 JC 病毒、脑膜炎和 HIV）以及操纵免疫系统的反应 （免疫重建综合症）。尽管每种疾病都是独特的，但有共同的免疫致病性 其中许多机制证明他们作为单一谱系上的实体进行研究是合理的。进一步探索 为此，并为了继续 2004 年类似研讨会上建立的合作，我们组织了 2 第二次 国际？罕见神经免疫性疾病的发病机制？研讨会将在喜来登酒店举行 巴尔的摩医学博士，2006 年 7 月 20 日至 22 日。研讨会不会以疾病为导向，而是以机制为导向 面向，并将涉及许多神经免疫疾病的讨论，因为它们与免疫机制有关 神经系统的自身免疫。 本次研讨会将重点关注罕见的神经免疫疾病，而不是 比该组中最常见的疾病 MS 更重要。然而，参与者将被邀请讨论进展 特别是在多发性硬化症方面，这些进展为其他神经免疫性疾病的研究提供了信息和教育。 参与者将探讨以下共同主题：遗传学和触发机制；体液的 对自身免疫的贡献；细胞对自身免疫、免疫细胞迁移的贡献；先天免疫 贡献；神经保护；神经免疫串扰；髓鞘再生；新颖的成像和新兴的 免疫疗法。参与者将了解这些疾病的相似之处，从而从相似的疾病中受益 治疗方法；以及它们的独特之处，阐明了独特治疗策略的必要性。这 研讨会的中心前提是通过讨论一组独特且共同的病理过程 罕见疾病，参与者将激发推进必要的新颖的合作研究 了解这些疾病。该研讨会规模较小，且互动性强，这与其他研讨会不同 大型研讨会通常强调更常见的神经免疫性疾病（尤其是多发性神经免疫性疾病） 硬化症）并且主要是说教性的。该研讨会将邀请高级和初级人员参加 科学家/学生，以促进对这些疾病的长期研究。诉讼程序将是 在医学文献中传播。