Mechanisms of Neurologic Disease Course

神经系统疾病机制课程

• 批准号: 7191889
• 负责人: James W. Geddes
• 金额: $ 4.22万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-25 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7191889
• 关键词: Alzheimer' s disease; Internet; computer assisted instruction; curriculum; education evaluation /planning; educational resource design /development; interactive multimedia; meeting /conference /symposium; nervous system disorder; neurobiology; neurology; neuropathology; neurosciences; postgraduate education; training; university

DESCRIPTION (provided by applicant): This R25 proposal is to support the development and implementation of a new graduate course, Mechanisms of Neurologic Disease, at the University of Kentucky (UK). UK has a strong program in neuroscience research. Our local chapter of the Society for Neuroscience includes 96 faculty, 105 graduate students, and 41 postdoctoral fellows. There are three Neuroscience T32 programs at UK, focusing on the biology of aging, sensory systems, and oxidative stress. This proposal reflects our efforts to develop a new course on the neurobiology of disease that meets and exceed the expectations outlined in the RFA and the NIH Neuroscience Blueprint. Mechanisms of Neurologic Disease is organized into 8 major themes including disorders of cell migration and signaling, channelopathies, metabolic and mitochondrial disorders, neuroimmune and transmissible disorders, neurodegenerative disorders and protein aggregation, triplet repeat disorders, acute CNS insults, and drug abuse and addiction. Mechanistic links among disorders will be emphasized. In addition, one module will focus on state-of-the-art and emerging methods in neurobiology of disease research such as biosensors. The course will consist of didactic presentations by basic and clinical neuroscientists in addition to "journal club" format discussions of recent primary literature focusing on disease mechanisms or translational research. Outside experts will also be invited to lecture and meet with the students. In addition to the lectures and journal club discussions, students must attend a consensus conference on the clinico-pathological diagnosis of Alzheimer's disease and related disorders, offered monthly in the Sanders-Brown Center on Aging, and attend a brain cutting session offered weekly by Pathology/Neuropathology. Additionally, the students and faculty will organize a one day conference on translational research in one of the thematic areas. Program evaluation will include short and long term questionnaires. Dissemination of course materials will be through a course-specific web page and a multimedia CD. The course will be required for neuroscience trainees.

描述（由申请人提供）：该 R25 提案旨在支持肯塔基大学（英国）新的研究生课程“神经系统疾病机制”的开发和实施。英国在神经科学研究方面拥有强大的计划。我们的神经科学学会当地分会包括 96 名教职人员、105 名研究生和 41 名博士后研究员。英国有三个神经科学 T32 项目，重点关注衰老生物学、感觉系统和氧化应激。该提案反映了我们为开发疾病神经生物学新课程所做的努力，该课程满足并超出 RFA 和 NIH 神经科学蓝图中概述的期望。神经系统疾病的机制分为 8 个主要主题，包括细胞迁移和信号传导疾病、通道病、代谢和线粒体疾病、神经免疫和传染性疾病、神经退行性疾病和蛋白质聚集、三联体重复疾病、急性中枢神经系统损伤以及药物滥用和成瘾。将强调疾病之间的机制联系。此外，其中一个模块将重点关注疾病研究神经生物学的最先进和新兴方法，例如生物传感器。该课程将包括基础和临床神经科学家的教学演示，以及针对疾病机制或转化研究的最新主要文献的“期刊俱乐部”形式的讨论。还将邀请外部专家为学生授课并与学生见面。除了讲座和期刊俱乐部讨论之外，学生还必须参加桑德斯-布朗衰老中心每月举办的关于阿尔茨海默病和相关疾病的临床病理诊断共识会议，并参加病理学每周举办的脑切割会议/神经病理学。此外，学生和教师将组织为期一天的主题领域之一的转化研究会议。计划评估将包括短期和长期调查问卷。课程材料的传播将通过特定于课程的网页和多媒体CD 进行。神经科学实习生必修该课程。