Mechanisms of Neurologic Disease Course

神经系统疾病机制课程

• 批准号: 7191889
• 负责人: James W. Geddes
• 金额: $ 4.22万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-25 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7191889
• 关键词: Alzheimer' s disease; Internet; computer assisted instruction; curriculum; education evaluation /planning; educational resource design /development; interactive multimedia; meeting /conference /symposium; nervous system disorder; neurobiology; neurology; neuropathology; neurosciences; postgraduate education; training; university

DESCRIPTION (provided by applicant): This R25 proposal is to support the development and implementation of a new graduate course, Mechanisms of Neurologic Disease, at the University of Kentucky (UK). UK has a strong program in neuroscience research. Our local chapter of the Society for Neuroscience includes 96 faculty, 105 graduate students, and 41 postdoctoral fellows. There are three Neuroscience T32 programs at UK, focusing on the biology of aging, sensory systems, and oxidative stress. This proposal reflects our efforts to develop a new course on the neurobiology of disease that meets and exceed the expectations outlined in the RFA and the NIH Neuroscience Blueprint. Mechanisms of Neurologic Disease is organized into 8 major themes including disorders of cell migration and signaling, channelopathies, metabolic and mitochondrial disorders, neuroimmune and transmissible disorders, neurodegenerative disorders and protein aggregation, triplet repeat disorders, acute CNS insults, and drug abuse and addiction. Mechanistic links among disorders will be emphasized. In addition, one module will focus on state-of-the-art and emerging methods in neurobiology of disease research such as biosensors. The course will consist of didactic presentations by basic and clinical neuroscientists in addition to "journal club" format discussions of recent primary literature focusing on disease mechanisms or translational research. Outside experts will also be invited to lecture and meet with the students. In addition to the lectures and journal club discussions, students must attend a consensus conference on the clinico-pathological diagnosis of Alzheimer's disease and related disorders, offered monthly in the Sanders-Brown Center on Aging, and attend a brain cutting session offered weekly by Pathology/Neuropathology. Additionally, the students and faculty will organize a one day conference on translational research in one of the thematic areas. Program evaluation will include short and long term questionnaires. Dissemination of course materials will be through a course-specific web page and a multimedia CD. The course will be required for neuroscience trainees.

描述（由申请人提供）：该R25提案是为了支持肯塔基大学（英国）的新研究生课程的开发和实施，即神经疾病的机制。英国在神经科学研究方面拥有强大的计划。我们的神经科学协会的当地分会包括96名教职员工，105名研究生和41名博士后研究员。英国有三个神经科学T32计划，重点介绍了衰老，感觉系统和氧化应激的生物学。该建议反映了我们为开发有关疾病神经生物学的新课程的努力，该课程符合RFA和NIH神经科学蓝图中概述的期望。神经系统疾病的机制被组织为8个主要主题，包括细胞迁移和信号传导，通道病，代谢和线粒体疾病，神经免疫性和可传播疾病，神经退行性疾病，蛋白质聚集，蛋白质聚集，三胞胎重复疾病，急性CNS和药物滥用和药物滥用和上瘾。将强调疾病之间的机械联系。此外，一个模块将专注于疾病研究（例如生物传感器）神经生物学的最新和新兴方法。该课程还将包括基本和临床神经科学家的教学演示，除了“期刊俱乐部”格式讨论最近针对疾病机制或转化研究的主要文献的讨论。外部专家还将邀请演讲并与学生见面。除了讲座和期刊俱乐部的讨论外，学生还必须参加关于阿尔茨海默氏病和相关疾病的临床病理学诊断的共识会议，并在桑德斯棕色衰老中心每月提供，并参加病理学/神经病理学每周提供的每周大脑切割课程。此外，学生和教职员工将在其中一个主题领域举办一日翻译研究会议。计划评估将包括短期和长期问卷。课程材料的传播将是通过特定课程的网页和多媒体CD进行的。神经科学学员需要该课程。