In-site Measurement of Plaque Biomechanical Properties

斑块生物力学特性的现场测量

• 批准号: 6881663
• 负责人: Brett E Bouma
• 金额: $ 34.42万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6881663
• 关键词: antihypercholesterolemic agent; atherosclerotic plaque; bioimaging /biomedical imaging; biomechanics; blood lipid; blood vessels; cardiovascular disorder chemotherapy; cardiovascular imaging /visualization; diagnosis design /evaluation; elasticity; laboratory rabbit; mechanical stress; nonhuman therapy evaluation; optical tomography; pathogenic diet

Description (provided by applicant): The overall goal of this research is to validate and apply an optical coherence tomography (OCT) imaging method for assessing stress, strain and compliance in coronary vessels in vivo. Acute myocardial infarction, the leading cause of death in industrialized countries, is frequently caused by rupture of a coronary atherosclerotic plaque. Current understanding of the relationship between biological, biochemical, and mechanical factors associated with rupture, however, is incomplete. We will develop and test a novel method that incorporates both fmite element analysis and intravascular elastography measurements with OCT to accurately assess vessel elastic properties. The proposed research will investigate the utility of our method to enhance the modeling of stress, strain and compliance in vessels from model systems to animal vasculature. We hypothesize that determining the elastic properties of vessels with our method will permit realistic modeling of vessel stress, strain and compliance in response to linear forces and pressures. The accuracy of our method will be assessed in models of graded pressure and localized forces. Subsequently, we will use the method to monitor vessel mechanical properties in a rabbit model of atherosclerosis. Principal stress, principal strain and tissue compliance will be monitored over time during plaque progression and during response to lipid lowering therapy. At sacrifice, these results will be correlated with histological fmdings. Our hypotheses are that 1) locations of elevated stress in lipid rich plaques become more compliant during plaque progression, and 2) stress and compliance in lipid rich plaques decrease in response to lipid-lowering therapy. The methods that will be developed in this work present the potential for characterizing the biomechanical properties of coronary plaques in vivo and may facilitate the development of improved therapeutic approaches.

描述（由申请人提供）：本研究的总体目标是 验证并应用光学相干断层扫描 (OCT) 成像方法 评估体内冠状血管的应力、应变和顺应性。急性 心肌梗塞是工业化国家的首要死因， 通常是由冠状动脉粥样硬化斑块破裂引起的。当前的 了解生物、生化和生物之间的关系 然而，与破裂相关的机械因素并不完整。我们将 开发并测试一种结合有限元分析的新方法 和 OCT 血管内弹性成像测量，以准确评估 血管弹性特性。 拟议的研究将调查我们的方法在增强 从模型系统到容器中的应力、应变和顺应性建模 动物脉管系统。我们假设确定弹性特性 使用我们的方法的血管将允许对血管应力、应变进行真实的建模 以及响应线性力和压力的顺应性。我们的准确性 该方法将在分级压力和局部力模型中进行评估。 随后，我们将使用该方法来监测船舶机械性能 兔动脉粥样硬化模型。主应力、主应变和 在斑块进展过程中，将随着时间的推移监测组织顺应性， 在对降脂治疗的反应期间。在牺牲的情况下，这些结果将是 与组织学检查结果相关。我们的假设是 1) 的位置 富含脂质的斑块中的压力升高，在斑块形成过程中变得更加顺应 进展，以及 2) 富含脂质斑块的压力和顺应性因响应而降低 降脂治疗。本工作中将开发的方法 表征冠状动脉生物力学特性的潜力 体内斑块并可能促进改进治疗方法的开发 接近。

项目成果

Measurement of fibrous cap thickness in atherosclerotic plaques by spatiotemporal analysis of laser speckle images.

通过激光散斑图像的时空分析测量动脉粥样硬化斑块中的纤维帽厚度。

• 发表时间: 2006-03
• 影响因子: 3.5
• 作者: Nadkarni, Seemantini K;Bilenca, Alberto;Bouma, Brett E;Tearney, Guillermo J
• 通讯作者: Tearney, Guillermo J

Elimination of depth degeneracy in optical frequency-domain imaging through polarization-based optical demodulation.

通过基于偏振的光学解调消除光学频域成像中的深度简并。

• 发表时间: 2006-02-01
• 影响因子: 3.6
• 作者: Vakoc, B J;Yun, S H;Tearney, G J;Bouma, B E
• 通讯作者: Bouma, B E

Comprehensive volumetric optical microscopy in vivo.

体内综合体积光学显微镜。

• 发表时间: 2006-12
• 影响因子: 82.9
• 作者: Yun, Seok H;Tearney, Guillermo J;Vakoc, Benjamin J;Shishkov, Milen;Oh, Wang Y;Desjardins, Adrien E;Suter, Melissa J;Chan, Raymond C;Evans, John A;Jang, Ik;Nishioka, Norman S;de Boer, Johannes F;Bouma, Brett E
• 通讯作者: Bouma, Brett E

Tissue elasticity estimation with optical coherence elastography: toward mechanical characterization of in vivo soft tissue.

使用光学相干弹性成像估计组织弹性：体内软组织的机械表征。

• 发表时间: 2005-11
• 影响因子: 3.8
• 作者: Khalil, Ahmad S;Chan, Raymond C;Chau, Alexandra H;Bouma, Brett E;Mofrad, Mohammad R Kaazempur
• 通讯作者: Mofrad, Mohammad R Kaazempur

Comparison of coronary plaque characteristics between diabetic and non-diabetic subjects: An in vivo optical coherence tomography study.

糖尿病和非糖尿病受试者之间冠状动脉斑块特征的比较：体内光学相干断层扫描研究。

• 发表时间: 2008-08
• 影响因子: 5.1
• 作者: Chia, Stanley;Raffel, O Christopher;Takano, Masamichi;Tearney, Guillermo J;Bouma, Brett E;Jang, Ik
• 通讯作者: Jang, Ik