CORE--Patient Services Core

CORE--患者服务核心

• 批准号: 6900244
• 负责人: Lillian E McMahon
• 金额: $ 7.17万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-20 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6900244
• 关键词: biomedical facility; continuing education; cooperative study; counseling; diagnostic tests; medical outreach /case finding; patient care; sickle cell anemia

The Patient Service Core brings to our patients, their families, community members, physicians and other health professionals, state-of-the-art educational, counseling, and diagnostic services made available because of the core of physician-scientists and allied health professionals associated with the Boston Comprehensive Sickle Cell Center. Through our outreach programs, we make services of the Boston Comprehensive Sickle Cell Center available to community members not receiving primary care at our major teaching hospitals. Professional counseling is provided to patients and families at risk for sickle cell disease and related disorders. We provide education to health professionals about sickle cell disease and related disorders. Education is also provided to patients and families at risk for sickle cell disease and related disorders. We also have established a hemoglobin diagnosis laboratoryproviding hemoglobinopathy screening using innovative technology and definitive hemoglobin diagnosis by mass spectrometry. A major limitation of HPLC for hemoglobinopathy detection is present during the study of sickle hemoglobinopathies where a clinically important interference exists between HbA2 and an adduct of HbS when using the Bio Rad Variant II method. Capillary zone electrophoresis, an alternative to isoelectric focusing, has found many uses in the research laboratory due to its simplicity, superior resolution, linearity, precision, reproducibility, speed of analysis, and automated operation. Using capillary zone electrophoresis the quantitation of HbA2 is not affected by the presence of HbS and capillary zone electrophoresis can resolve HbA1c from carbamylated HbA1a, A1b, A1d, F, C, and O-Arab. We will explore and develop the use of capillary zone electrophoresis for routine hemoglobinopathy and thalassemia detection.

患者服务核心为我们的患者，他们的家人，社区成员，医生和其他卫生专业人员，最先进的教育，咨询和诊断服务提供了服务，这是由于医师科学家和与波士顿综合镰状细胞中心相关的相关卫生专业人员的核心而提供的。通过我们的外展计划，我们为在我们的主要教学医院接受初级保健的社区成员提供了波士顿综合镰状细胞中心的服务。向有镰状细胞疾病和相关疾病的患者和家庭提供专业咨询。我们向卫生专业人员提供有关镰状细胞疾病和相关疾病的教育。还向有镰状细胞疾病和相关疾病风险的患者和家庭提供教育。我们 还建立了使用创新技术和确定的血红蛋白诊断的血红蛋白诊断实验室提供的血红蛋白病筛查。 HPLC在研究镰状血红蛋白病的研究中存在HPLC检测的主要局限性，在使用Beio Rad rad variant II方法时，HBA2和HBS的加合物之间存在临床上重要的干扰。毛细管区电泳是等电聚焦的一种替代方案，由于其简单性，优越的分辨率，线性，精度，可重复性，分析速度和 自动操作。使用毛细管电泳，HBS的存在不受HBS和毛细管电泳的存在的影响，可以从卡氨基化的HBA1A，A1B，A1D，F，C和O-Arab解决HBA1C。我们将探索和开发使用毛细管电泳的使用，以进行常规的血红蛋白病和丘脑质性检测。