NEUROPSYCHOLOGICAL DYSFUNCTION AND NEUROIMAGING ABNORMALITIES IN SCD

SCD 的神经心理功能障碍和神经影像异常

• 批准号: 7606262
• 负责人: Lillian E McMahon
• 金额: $ 0.73万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606262
• 关键词: Adult; Anemia; Attention; Brain Injuries; Computer Retrieval of Information on Scientific Projects Database; Condition; Event; Functional disorder; Funding; Grant; Institution; Intervention; Link; Magnetic Resonance Imaging; Memory; Neuropsychological Tests; Participant; Patients; Phase; Purpose; Randomized Controlled Clinical Trials; Research; Research Personnel; Resources; Sickle Cell; Sickle Cell Anemia; Source; Stroke; Testing; Transfusion; United States National Institutes of Health; Upper arm; experience; improved; neuroimaging; neuropsychological; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to determine the extent of memory and attention problems in adults with sickle cell disease. Adults who have not experienced a stroke or other brain damage will be asked to join the study. The study will also evaluate the link between these events or conditions and abnormal MRI. These findings will be compared to healthy people with similar backgrounds. For some participants, testing will show evidence of problems with memory and attention, potentially caused by the anemia that occurs among most patients with sickle cell disease. Correcting anemia has been linked in some non-sickle cell patients with better memory and attention. A second part of the study will involve treating anemia for six months in a subset of subjects who have completed the neuropsychological testing and MRI to assess the effect of trnasfusion on memory and attention. This second study phase is a randomized controlled clinical trial. Patients in the treatment arm of the study will receive six monthly transfusions as a potential treatment to improve memory. Patients in the non-intervention group will receive no transfusion therapy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是确定镰状细胞疾病的成年人的记忆和注意力问题的程度。未遭受中风或其他脑部损伤的成年人将被要求加入研究。该研究还将评估这些事件或条件和异常MRI之间的联系。这些发现将与背景相似的健康人进行比较。对于某些参与者，测试将显示出记忆和注意力问题的证据，这可能是由于大多数镰状细胞疾病患者中发生的贫血引起的。在一些具有更好记忆力和注意力的非sickle细胞患者中，纠正贫血已连接。该研究的第二部分将涉及在完成神经心理学测试和MRI的一部分中治疗贫血六个月，以评估TrnasFusion对记忆和注意力的影响。第二个研究阶段是一项随机对照临床试验。研究部门的患者将接受六次每月输血，以作为改善记忆力的潜在治疗方法。非干预组的患者将不接受输血疗法。