MRI-Based Elasticity Imaging

基于 MRI 的弹性成像

• 批准号: 7053020
• 负责人: JOHN B WEAVER
• 金额: $ 15.53万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7053020
• 关键词: behavior; elasticity; mammary gland; tissues

Tissue elasticity is widely held as being strongly associated with disease, especially breast malignancy given the prominent place that physical examination holds in breast cancer screening. As a result, a sizeable technology effort has emerged to develop and evaluate new concepts for measuring and imaging parameters related to the mechanical characteristics of breast tissue. Project I, Magnetic Resonance Elastography (MRE), exploits phase contrast techniques to encode induced harmonic mechanical wave motion into phase accumulations during customized gradients to map the full displacement field in three dimensions from which mechanical property estimates are derived at or near the MR acquisition resolution. During the current funding period, Project I has successfully realized a robust MRE technique which has been deployed on a limited basis during clinical breast exams to demonstrate feasibility, provide preliminary estimates of the mechanical properties of normal breast, and highlight opportunities for extracting more complex mechanical behaviors. The existing MRE method is ready for systematic clinical deployment and will be used in a research plan consisting of (a) clinical evaluation, (b) continued technical advancement and (c) histopathological correlation to begin to identify the biological signatures of mechanical property contrast. The specific aims for continuation of Project I include (1) development of MRE driving and reconstruction techniques to estimate viscoelastic mechanical behavior in breast tissue, (2) Optimization of image acquisition sequences and methods to reduce exam time (3) exploration of shear modulus and viscoelastic property correlations with histopathological analyses in mastectomy specimens where adequate tissue is available to spatially sample and orient the imaged volume, and (4) participation in the clinical study designs executed by the Clinical Core targeting screening abnormalities recommended for biopsy, palpable masses on clinical breast exams and pilot exams of locally-advanced disease receiving neoadjuvant therapy. If successful, these aims are expected to generate evidence sufficient to estimate convincingly the potential of MRE to contribute to differential diagnosis, and pilot data in support of a role in treatment prognosis and therapy monitoring which will inform decisions on the initiation of larger clinical trials with MRE in the future.

组织弹性被广泛认为与疾病密切相关，尤其是乳房恶性肿瘤 体格检查在乳腺癌筛查中的重要位置。结果，很大 已经出现了技术努力来开发和评估测量和成像的新概念 与乳房组织的机械特征有关的参数。项目I，磁共振 弹性图（MRE），利用相对造影剂来编码诱导的谐波机械波 在定制梯度期间运动成相积累，以绘制三个中的整个位移字段 在MR采集分辨率或附近得出机械性能估计的维度。 在当前的资金期间，我成功地意识到了一种强大的MRE技术 在临床乳房检查期间以有限的基础部署，以证明可行性，提供初步 估计正常乳房的机械性能，并突出了提取更多的机会 复杂的机械行为。现有的MRE方法已准备好进行系统的临床部署和 将用于（a）临床评估，（b）持续技术进步和 （c）组织病理学相关性开始确定机械性质对比的生物学特征。 继续项目的具体目的我包括（1）开发MRE驾驶和重建 估计乳腺组织中粘弹性机械行为的技术，（2）图像的优化 减少考试时间的采集序列和方法（3）探索剪切模弹和粘弹性 与足够组织的乳房切除术标本中组织病理学分析的性质相关性 可用于空间采样和定向成像的体积，（4）参与临床研究设计 由临床核心靶向筛查异常执行，建议活检，可触及的质量 关于接受新辅助治疗的局部疾病的临床乳房检查和试点考试。如果 成功，这些目标有望产生足以令人信服的证据 MRE有助于鉴别诊断，并进行试验数据，以支持治疗预后和 治疗监测将为将来使用MRE启动更大临床试验的决策。