Core--Research Translation

核心--研究翻译

• 批准号: 6897640
• 负责人: Keith Pezzoli
• 金额: $ 15.39万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6897640
• 关键词: bioaccumulation; biomarker; biomedical facility; biosensor device; cooperative study; detoxification; environmental health; environmental toxicology; hazardous substances; toxin metabolism

DESCRIPTION (provided by applicant): The Research Translation Core (RTC) of UCSD SBRP has four Specific Aims: 1) build partnerships with government agencies and Tribal science labs to advance the practical contributions of toxicogenomics in environmental policy and planning; 2) evaluate the utility of molecular biomarkers/biosensors, microtechnologies and bioremediation as new biological models/methods for improving environmental monitoring, risk assessment and remediation; 3) organize technology showcases, entrepreneurs/innovators forums and educational workshops to foster the commercial development and utilization of innovative SBRP technologies; and 4) communicate complex research findings to broad audiences through periodic workshops; symposia; participation in regional, national and international conferences; publications, and Web-based systems. The broad long-term objective is to apply toxicogenomic knowledge and biomolecular technologies to real-life problems concerning hazardous substances and environmental health. Along these lines, biomarkers developed by SBRP scientists will be evaluated, in partnership with the San Diego Baykeeper, Tribal labs and government agencies responsible for water quality monitoring, as potentially effective new cellular and analytic tools for detecting Superfund toxicants in contaminated watersheds. At the same time, SBRP-industry partnerships will promote the experimental development and commercialization of novel bioremediation technologies (e.g., transgenic plants that can hyper-accumulate heavy metals out of contaminated soil), and microtechnologies (e.g., labs-on-a-chip that can be used as biosensors for detecting exposure to pesticides). The RTC's approach leverages strong working partnerships and information/visualization technologies already developed by the Regional Workbench Consortium (RWBC) in partnership with the San Diego Supercomputer Center. The RWBC was established as part of the UCSD SRRP Outreach Core (2000-2005); it is a Web-based research and learning network for sustainable development. The RTC's toolkit includes on-line geographic information systems (GIS), decision support systems (DSS), multimedia interactive stories, and 3D visualization.

描述（由申请人提供）：UCSD SBRP的研究翻译核心（RTC） 四个具体目标：1）与政府机构和部落科学实验室建立合作伙伴关系，以促进毒物基因组学在环境政策和计划中的实际贡献； 2）评估分子生物标志物/生物传感器，微技术和生物修复的效用，作为改善环境监测，风险评估和补救的新生物学模型/方法； 3）组织技术展览会，企业家/创新者论坛和教育研讨会，以促进创新SBRP技术的商业开发和利用； 4）通过定期研讨会向广泛的观众传达复杂的研究结果；座谈会；参加区域，国家和国际会议；出版物和基于网络的系统。广泛的长期目标是将毒理学知识和生物分子技术应用于有关危险物质和环境健康的现实生活问题。 沿着这些线路，将与SBRP科学家开发的生物标志物与圣地亚哥海湾管理员，部落实验室和负责水质监测的政府机构合作评估，作为潜在的有效新的新 用于检测受污染流域中超级基金有毒物质的细胞和分析工具。 同时，SBRP-Industry合作伙伴关系将促进新型生物修复技术的实验开发和商业化（例如，可以从受污染的土壤中过度蓄能的重金属的转基因植物和微型技术（例如，可以用作生物传感器的实验室）来检测percessublices experseporse）。 RTC的方法利用了由区域工作台联盟（RWBC）与圣地亚哥超级计算机中心合作开发的强大工作伙伴关系和信息/可视化技术。 RWBC是UCSD SRRP外展核心（2000-2005）的一部分。它是一个基于网络的研究和学习网络，用于可持续发展。 RTC的工具包包括在线地理信息系统（GIS），， 决策支持系统（DSS），多媒体互动故事和3D可视化。